iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-131982

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

WD repeat, sterile alpha motif and U-box domain-containing 1

Genbank Nucleotide ID

AAMC01021149

Gene Name

wdsub1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000007589.3	ENSXETT00000016520.3	ENSXETP00000016520.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.80e-24	84.7	402	473
E3 adaptor/Cullin RING/DCX/DWD	1.30e-37	126.3	10	44
UBD/Beta-Prp	3.30e-52	177.7	5	215

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawceens 73
           +p eflCpI+ elM dPv++++G++y+r++Ie w++++++t+P+t+ +l++  l+Pn tl+   ++w+e+++
   Q: 402  IPNEFLCPITWELMMDPVIASDGYSYERKAIEDWISRKKRTSPMTNLTLENLLLTPNRTLKMALNHWLERQK 473
           8*******************************************************************9987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           gH+d+v++++fsd +++s+s D+t++v++l++++ 
   Q: 10   GHSDDVNSCSFSDSYVASCSLDKTLRVYSLKDFKE 44
           8**********889***************999875 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgk..cvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           + +l+gh++ v++++fs++  + +++s D+t++v++l+++k  +++ lkgh++ v  + f p++  l+s s d    +w++++gq l  
   Q: 5    ICELKGHSDDVNSCSFSDS--YVASCSLDKTLRVYSLKDFKelPFSPLKGHTYGVHWCCFAPDKPILASCSTDGKTILWNMHNGQMLAV 91
           6689***************..8****************776447899*****************************************7 PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
           ++++  + v++ ++++++n+l++G++D+ + lW+++++k  r  t  +++s+   +f++ g+ l++gs  g+++ wd  + +c++  +g
   Q: 92   LEQPSGSPVRVCRYSSNSNYLATGGADGSIVLWNVQQMKFHRSATV-KDGSIVACAFSPHGNLLITGSSCGDLTAWDE-NLKCLYNDKG 178
           7888888999******99**************************98.******************************7.778******* PP
   S: 221  htdnvksvrfs........pnderlvsgssDgsiriW 249
           h+  v++ +fs         +   ++s+++D+ ir+W
   Q: 179  HDLGVTCCDFSsqtvyergIEYYQMASCGQDNEIRVW 215
           ***********665555433445589999*******9 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MARFICELKG HSDDVNSCSF SDSYVASCSL DKTLRVYSLK DFKELPFSPL KGHTYGVHWC 60
CFAPDKPILA SCSTDGKTIL WNMHNGQMLA VLEQPSGSPV RVCRYSSNSN YLATGGADGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGAGGT TCATTTGTGA GCTGAAAGGC CACTCAGACG ACGTAAACAG CTGCAGTTTC 60
TCTGATTCCT ACGTGGCCTC ATGCTCTTTG GATAAGACTC TCCGGGTTTA TTCCCTAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001660--SAM
IPR013761--SAM/pointed
IPR003613--Ubox_domain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50105--SAM_DOMAIN
PS51698--U_BOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07647--SAM_2
PF04564--U-box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00454--SAM
SM00504--Ubox
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

xtr:100487088

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001614	Ailuropoda melanoleuca	61.47	8.00e-176	609.00
IUUC-Apl-003529	Anas platyrhynchos	62.32	5.00e-176	610.00
IUUC-Aca-004257	Anolis carolinensis	58.35	5.00e-170	590.00
IUUC-Ame-011357	Astyanax mexicanus	44.72	6.00e-101	360.00
IUUC-Bta-013032	Bos taurus	61.57	6.00e-174	603.00
IUUC-Cja-018743	Callithrix jacchus	61.26	6.00e-173	600.00
IUUC-Cfa-021197	Canis familiaris	60.21	9.00e-174	602.00
IUUC-Cpo-022279	Cavia porcellus	61.68	1.00e-175	609.00
IUUC-Csa-023954	Chlorocebus sabaeus	61.89	1.00e-175	609.00
IUUC-Cho-025083	Choloepus hoffmanni	50.67	3.00e-98	351.00
IUUC-Cin-025786	Ciona intestinalis	36.60	8.00e-82	297.00
IUUC-Dre-028087	Danio rerio	52.35	1.00e-131	462.00
IUUC-Dno-028919	Dasypus novemcinctus	61.26	7.00e-174	603.00
IUUC-Dor-031112	Dipodomys ordii	60.42	3.00e-170	591.00
IUUC-Ete-032405	Echinops telfairi	61.65	4.00e-117	414.00
IUUC-Eca-033254	Equus caballus	59.49	1.00e-170	592.00
IUUC-Eeu-034545	Erinaceus europaeus	59.16	6.00e-164	570.00
IUUC-Fca-035482	Felis catus	61.68	3.00e-174	604.00
IUUC-Fal-036976	Ficedula albicollis	51.96	3.00e-126	444.00
IUUC-Gmo-039213	Gadus morhua	50.21	1.00e-124	439.00
IUUC-Gga-040561	Gallus gallus	61.54	1.00e-172	598.00
IUUC-Gac-041471	Gasterosteus aculeatus	51.06	6.00e-123	434.00
IUUC-Ggo-045503	Gorilla gorilla	61.47	1.00e-174	605.00
IUUC-Hsa-045910	Homo sapiens	61.47	8.00e-175	606.00
IUUC-Itr-048214	Ictidomys tridecemlineatus	59.68	2.00e-134	471.00
IUUC-Loc-052307	Lepisosteus oculatus	52.59	2.00e-148	519.00
IUUC-Laf-053587	Loxodonta africana	61.26	9.00e-176	609.00
IUUC-Mcc-055679	Macaca mulatta	61.68	7.00e-175	606.00
IUUC-Meu-055962	Macropus eugenii	53.47	3.00e-133	468.00
IUUC-Mga-059652	Meleagris gallopavo	61.19	2.00e-174	605.00
IUUC-Mmr-060943	Microcebus murinus	60.59	6.00e-168	583.00
IUUC-Mdo-062592	Monodelphis domestica	61.72	1.00e-172	598.00
IUUC-Mmu-063577	Mus musculus	59.58	3.00e-165	574.00
IUUC-Mpu-066422	Mustela putorius furo	61.26	5.00e-175	607.00
IUUC-Mlu-067250	Myotis lucifugus	60.63	5.00e-172	597.00
IUUC-Nle-069517	Nomascus leucogenys	61.68	2.00e-175	608.00
IUUC-Opr-070776	Ochotona princeps	60.84	3.00e-170	591.00
IUUC-Ont-071821	Oreochromis niloticus	51.06	5.00e-132	464.00
IUUC-Oan-073706	Ornithorhynchus anatinus	62.74	3.00e-175	607.00
IUUC-Ocu-074766	Oryctolagus cuniculus	55.97	8.00e-153	533.00
IUUC-Ola-086531	Oryzias latipes	50.32	3.00e-127	448.00
IUUC-Oga-088388	Otolemur garnettii	62.11	2.00e-176	611.00
IUUC-Oar-089748	Ovis aries	62.63	4.00e-176	610.00
IUUC-Ptr-090616	Pan troglodytes	61.75	2.00e-173	601.00
IUUC-Pan-091769	Papio anubis	60.23	4.00e-118	417.00
IUUC-Psi-093334	Pelodiscus sinensis	64.58	3.00e-168	584.00
IUUC-Pma-094383	Petromyzon marinus	45.31	2.00e-117	416.00
IUUC-Pfo-096801	Poecilia formosa	50.00	8.00e-128	450.00
IUUC-Pab-098139	Pongo abelii	61.08	3.00e-139	488.00
IUUC-Pca-100523	Procavia capensis	60.32	3.00e-114	405.00
IUUC-Pva-102286	Pteropus vampyrus	62.29	2.00e-169	588.00
IUUC-Rno-104831	Rattus norvegicus	59.21	4.00e-166	577.00
IUUC-Sha-107499	Sarcophilus harrisii	62.74	5.00e-174	603.00
IUUC-Sar-113389	Sorex araneus	60.42	4.00e-167	580.00
IUUC-Ssc-116089	Sus scrofa	26.85	6.00e-24	104.00
IUUC-Tgu-116769	Taeniopygia guttata	60.84	2.00e-168	584.00
IUUC-Tru-118774	Takifugu rubripes	49.59	3.00e-125	441.00
IUUC-Tsy-119595	Tarsius syrichta	52.81	8.00e-114	403.00
IUUC-Tni-119850	Tetraodon nigroviridis	51.06	2.00e-131	462.00
IUUC-Tbe-127938	Tupaia belangeri	54.93	1.00e-91	329.00
IUUC-Ttr-128193	Tursiops truncatus	60.33	4.00e-146	511.00
IUUC-Vpa-130275	Vicugna pacos	60.63	2.00e-171	595.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence