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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063902
Ensembl Protein ID ENSMUSP00000137116.1
UniProt Accession Q3UN58; A2ADD8; Q0VG17; FAP20_MOUSE
Genbank Protein ID BAE25889.1; CAM20052.1; CAO77979.1; AAI17035.1; ENSMUSP00000095354
Protein Name Fanconi anemia core complex-associated protein 20; FANCA-associated protein of 20 kDa; Fanconi anemia-associated protein of 20 kDa
Genbank Nucleotide ID AK144436; AL670413; AL670413; BC117034; CA457860
Gene Name Faap20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000073684.13 ENSMUST00000148406.7 ENSMUSP00000117360.1
ENSMUSG00000073684.13 ENSMUST00000105627.7 ENSMUSP00000101252.1
ENSMUSG00000073684.13 ENSMUST00000097747.8 ENSMUSP00000095354.2
ENSMUSG00000073684.13 ENSMUST00000143709.1 ENSMUSP00000121522.1
ENSMUSG00000073684.13 ENSMUST00000178473.7 ENSMUSP00000137116.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 25917546
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 6.90e-07 30.5 150 177
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 1    llvCPvCqkm....vdqtdfeeHlDeCl 24
           ll+CP+Cqk+    ++q d+++Hl++Cl
   Q: 150  LLSCPLCQKAfdpkLTQLDVDSHLAQCL 177
           589************************8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity).
 Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity).
Protein Sequence
(Fasta)
MEEERRLRGR LSRRRPPAGG GPPNCRPWFL SEGSKSEPWA ALLRSTVSGT ADWTPNRQPL 60
PPLPAFPSQE SLPDPESTVP PEAFTVGSKT FSWTPLPPAL RGSGSSRHLF CEPEGSLGSP 120
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Protein Fasta Sequence


>IUUC-Mmu-063902|UBD,UBZ|Mus musculus
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Nucleotide Sequence
(Fasta)
CCCGCCTCTC CCTCAAGGCG GCAGCCTCGT GTTCCCAACG GTTGGGATCT CGGCGCCTTA 60
GATTTCCAGC GCCACAAAGG GGAGCTGGCA CTTGGCAGAG CGGAGAGTGG GGGGGGTCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063902|UBD,UBZ|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR031491--FANCA_interact
IPR031490--UBZ_FAAP20
Pfam

PF15751--FANCA_interact
PF15750--UBZ_FAAP20
Gene Ontology

GO:0030054--C:cell junction
GO:0005694--C:chromosome
GO:0043240--C:Fanconi anaemia nuclear complex
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0036297--P:interstrand cross-link repair
GO:0019985--P:translesion synthesis
KEGG mmu:67513
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002409 Ailuropoda melanoleuca 44.07 5.00e-06 42.40
IUUC-Bta-013416 Bos taurus 39.02 5.00e-16 77.40
IUUC-Cja-019117 Callithrix jacchus 50.30 3.00e-27 115.00
IUUC-Cpo-021546 Cavia porcellus 68.52 2.00e-15 73.60
IUUC-Csa-024066 Chlorocebus sabaeus 50.00 9.00e-29 119.00
IUUC-Dno-029273 Dasypus novemcinctus 62.75 7.00e-13 65.50
IUUC-Ete-033066 Echinops telfairi 40.83 5.00e-24 103.00
IUUC-Eca-033947 Equus caballus 45.03 4.00e-23 100.00
IUUC-Eeu-034567 Erinaceus europaeus 51.32 1.00e-22 98.60
IUUC-Gac-041654 Gasterosteus aculeatus 54.05 3.00e-07 47.40
IUUC-Ggo-045315 Gorilla gorilla 52.83 4.00e-29 121.00
IUUC-Hsa-046575 Homo sapiens 53.12 5.00e-31 127.00
IUUC-Itr-048140 Ictidomys tridecemlineatus 57.86 6.00e-28 116.00
IUUC-Laf-054078 Loxodonta africana 45.35 6.00e-23 100.00
IUUC-Mmr-060675 Microcebus murinus 48.77 4.00e-25 107.00
IUUC-Nle-069135 Nomascus leucogenys 53.75 5.00e-32 130.00
IUUC-Oga-088370 Otolemur garnettii 54.71 4.00e-36 144.00
IUUC-Oar-090037 Ovis aries 42.05 2.00e-10 59.70
IUUC-Ptr-091600 Pan troglodytes 51.81 3.00e-30 124.00
IUUC-Pan-091731 Papio anubis 51.46 6.00e-32 130.00
IUUC-Pfo-096538 Poecilia formosa 47.37 1.00e-06 45.40
IUUC-Pab-098384 Pongo abelii 51.57 2.00e-28 119.00
IUUC-Pca-100684 Procavia capensis 42.37 4.00e-26 110.00
IUUC-Rno-105623 Rattus norvegicus 85.28 7.00e-72 262.00
IUUC-Sha-107222 Sarcophilus harrisii 59.09 7.00e-13 66.20
Created Date 25-Jun-2017

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