iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_Other	UBQ_Other	12799444

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	1.70e-34	118.6	430	503

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekks 74
           +qv+vk++dg+++ + ++p d V++LK++ie+++g+++++qrL ++G+iLed+ ++++yg++d  t++l  +++
   Q: 430  IQVFVKNPDGRSHAYAIHPLDYVLNLKQQIEDRQGLRCQEQRLEFQGHILEDWFDFKSYGIQDSVTVILSKTTE 503
           79*************************************************************99999987776 PP

Organism

Mus musculus

Functional Description
(View)

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L.

Protein Sequence
(Fasta)

MAVAQELYGF PASKLDSFVA QWLQPTREWK EEVLETVQTV EQFLRQENFR EDRGPARDVR 60
VLKVLKVGCF GNGTVLRSTT DVELVVFLSC FHSFQEEAKH HQAVLRLIQK RMYYCQELMD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCCATGC TCCCAAGCTT CTCTCTTCAC CCCCCTTTCC GCCATTGGGT GCCAGAGGTC 60
AGCTGGAAAG GAGCCGCCTT AAAAAAGGAG GAGGTGAGTA CCGGCAGCTG GATGGGTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding

Interpro

IPR006117--2-5-oligoadenylate_synth_CS
IPR006116--2-5-oligoadenylate_synth_N
IPR018952--2-5-oligoAdlate_synth_1_dom2/C
IPR026774--2-5A_synthase
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS00833--25A_SYNTH_2
PS50152--25A_SYNTH_3
PS50053--UBIQUITIN_2

Pfam

PF10421--OAS1_C
PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0003723--F:RNA binding
GO:0016740--F:transferase activity
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0045071--P:negative regulation of viral genome replication
GO:0009615--P:response to virus

KEGG

mmu:231655

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002382	Ailuropoda melanoleuca	69.34	2.00e-145	509.00
IUUC-Bta-013441	Bos taurus	60.45	5.00e-116	410.00
IUUC-Cja-019721	Callithrix jacchus	65.44	0.00e+00	640.00
IUUC-Cfa-020283	Canis familiaris	67.12	0.00e+00	713.00
IUUC-Cpo-022264	Cavia porcellus	72.10	0.00e+00	761.00
IUUC-Csa-024258	Chlorocebus sabaeus	71.07	0.00e+00	729.00
IUUC-Cho-024633	Choloepus hoffmanni	69.26	0.00e+00	723.00
IUUC-Dno-029276	Dasypus novemcinctus	66.47	0.00e+00	704.00
IUUC-Dor-030563	Dipodomys ordii	61.05	4.00e-116	410.00
IUUC-Ete-032293	Echinops telfairi	65.44	0.00e+00	673.00
IUUC-Eca-033538	Equus caballus	69.71	0.00e+00	696.00
IUUC-Eeu-035066	Erinaceus europaeus	46.99	3.00e-84	305.00
IUUC-Fca-036598	Felis catus	68.86	4.00e-147	514.00
IUUC-Ggo-045019	Gorilla gorilla	70.29	0.00e+00	719.00
IUUC-Hsa-046427	Homo sapiens	70.29	0.00e+00	719.00
IUUC-Laf-054072	Loxodonta africana	70.87	0.00e+00	732.00
IUUC-Mcc-054678	Macaca mulatta	70.29	0.00e+00	721.00
IUUC-Meu-056079	Macropus eugenii	52.35	3.00e-99	355.00
IUUC-Mmr-061797	Microcebus murinus	65.12	0.00e+00	660.00
IUUC-Mdo-062316	Monodelphis domestica	45.74	3.00e-133	468.00
IUUC-Mpu-066799	Mustela putorius furo	66.54	0.00e+00	674.00
IUUC-Mlu-067737	Myotis lucifugus	63.20	6.00e-162	563.00
IUUC-Nle-069345	Nomascus leucogenys	70.87	0.00e+00	721.00
IUUC-Opr-070745	Ochotona princeps	65.26	3.00e-172	597.00
IUUC-Ocu-073828	Oryctolagus cuniculus	66.60	0.00e+00	669.00
IUUC-Oga-089118	Otolemur garnettii	67.61	2.00e-132	464.00
IUUC-Oar-089587	Ovis aries	58.37	2.00e-158	552.00
IUUC-Ptr-091642	Pan troglodytes	70.33	0.00e+00	707.00
IUUC-Pan-091943	Papio anubis	70.68	0.00e+00	726.00
IUUC-Pab-097945	Pongo abelii	70.29	0.00e+00	717.00
IUUC-Pca-100234	Procavia capensis	68.18	0.00e+00	682.00
IUUC-Pva-102228	Pteropus vampyrus	64.26	0.00e+00	638.00
IUUC-Rno-105099	Rattus norvegicus	88.67	0.00e+00	927.00
IUUC-Sha-106945	Sarcophilus harrisii	43.00	1.00e-115	410.00
IUUC-Sar-113443	Sorex araneus	58.02	1.00e-138	486.00
IUUC-Ssc-115350	Sus scrofa	58.06	3.00e-107	381.00
IUUC-Tgu-117171	Taeniopygia guttata	40.20	9.00e-97	347.00
IUUC-Tsy-119083	Tarsius syrichta	69.40	2.00e-127	449.00
IUUC-Tbe-127345	Tupaia belangeri	69.93	1.00e-124	439.00
IUUC-Ttr-128992	Tursiops truncatus	55.59	2.00e-102	365.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence