iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.80e-13	51.8	45	110

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+lvv++++++ah+  La +S++F+++f+ +++e   +++ve+ + ++  ++a+++FlY+++l++
   Q: 45   CDVVLVVEEQQVPAHRNLLAVCSDYFNSMFTLGMREAF-QKEVELVGTSYVGLKAVVDFLYSSELEL 110
           9************************************9.************************9976 PP

Organism

Mus musculus

Functional Description
(View)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MEASKQMRVS RPYKISESSK VYHWPDHSTA VLQRLNEQRL HGLFCDVVLV VEEQQVPAHR 60
NLLAVCSDYF NSMFTLGMRE AFQKEVELVG TSYVGLKAVV DFLYSSELEL DGSNIDYILE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGTGTAG GCTCGCACTT CCTTGCAGAG GGATGGCTGC GCTTCGGGCG GGCCCGGTAG 60
CCCCGCAGTG TGCGCTGCTC TGGTAGCGGC TCGCAAGCGG GCGCGATCCG GGCTCGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030585--KLHL36
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

mmu:234796

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001869	Ailuropoda melanoleuca	85.85	0.00e+00	992.00
IUUC-Apl-003806	Anas platyrhynchos	79.63	0.00e+00	954.00
IUUC-Ame-010908	Astyanax mexicanus	62.66	0.00e+00	721.00
IUUC-Bta-013146	Bos taurus	84.55	0.00e+00	995.00
IUUC-Cja-019679	Callithrix jacchus	86.85	0.00e+00	913.00
IUUC-Cfa-021265	Canis familiaris	85.69	0.00e+00	985.00
IUUC-Cpo-021740	Cavia porcellus	83.95	0.00e+00	973.00
IUUC-Csa-023308	Chlorocebus sabaeus	85.53	0.00e+00	1020.00
IUUC-Dre-028415	Danio rerio	62.44	0.00e+00	699.00
IUUC-Dno-029110	Dasypus novemcinctus	86.67	0.00e+00	1066.00
IUUC-Dor-030909	Dipodomys ordii	85.85	0.00e+00	1029.00
IUUC-Ete-032401	Echinops telfairi	79.17	0.00e+00	918.00
IUUC-Eca-033226	Equus caballus	85.85	0.00e+00	991.00
IUUC-Eeu-035083	Erinaceus europaeus	79.93	0.00e+00	855.00
IUUC-Fca-036492	Felis catus	87.17	0.00e+00	983.00
IUUC-Fal-036853	Ficedula albicollis	75.76	0.00e+00	890.00
IUUC-Gga-040333	Gallus gallus	79.46	0.00e+00	953.00
IUUC-Ggo-044986	Gorilla gorilla	85.69	0.00e+00	1019.00
IUUC-Hsa-046392	Homo sapiens	85.53	0.00e+00	1020.00
IUUC-Itr-048578	Ictidomys tridecemlineatus	87.05	0.00e+00	1037.00
IUUC-Lch-050297	Latimeria chalumnae	75.28	0.00e+00	923.00
IUUC-Loc-052521	Lepisosteus oculatus	73.50	0.00e+00	910.00
IUUC-Laf-054504	Loxodonta africana	86.83	0.00e+00	1046.00
IUUC-Mcc-055755	Macaca mulatta	85.53	0.00e+00	1020.00
IUUC-Mga-059643	Meleagris gallopavo	79.29	0.00e+00	953.00
IUUC-Mmr-061423	Microcebus murinus	75.83	0.00e+00	734.00
IUUC-Mdo-062792	Monodelphis domestica	81.57	0.00e+00	944.00
IUUC-Mpu-065736	Mustela putorius furo	84.72	0.00e+00	1035.00
IUUC-Mlu-068053	Myotis lucifugus	85.85	0.00e+00	1026.00
IUUC-Nle-069092	Nomascus leucogenys	74.31	0.00e+00	864.00
IUUC-Opr-070407	Ochotona princeps	80.64	0.00e+00	951.00
IUUC-Ont-071640	Oreochromis niloticus	64.81	0.00e+00	732.00
IUUC-Oan-073279	Ornithorhynchus anatinus	79.19	0.00e+00	992.00
IUUC-Ocu-074611	Oryctolagus cuniculus	82.95	0.00e+00	1008.00
IUUC-Ola-086508	Oryzias latipes	63.85	0.00e+00	764.00
IUUC-Oga-088008	Otolemur garnettii	86.34	0.00e+00	1030.00
IUUC-Oar-089990	Ovis aries	82.36	0.00e+00	935.00
IUUC-Ptr-091303	Pan troglodytes	85.69	0.00e+00	1021.00
IUUC-Pan-092647	Papio anubis	85.53	0.00e+00	1020.00
IUUC-Pfo-096164	Poecilia formosa	55.82	0.00e+00	672.00
IUUC-Pab-097655	Pongo abelii	85.53	0.00e+00	1014.00
IUUC-Pca-101101	Procavia capensis	84.88	0.00e+00	1009.00
IUUC-Rno-105423	Rattus norvegicus	97.88	0.00e+00	1189.00
IUUC-Sha-107381	Sarcophilus harrisii	80.49	0.00e+00	984.00
IUUC-Tgu-116910	Taeniopygia guttata	79.46	0.00e+00	938.00
IUUC-Tru-117937	Takifugu rubripes	60.58	0.00e+00	694.00
IUUC-Tsy-119012	Tarsius syrichta	85.66	0.00e+00	853.00
IUUC-Tni-120541	Tetraodon nigroviridis	59.77	0.00e+00	732.00
IUUC-Tbe-127500	Tupaia belangeri	85.69	0.00e+00	1022.00
IUUC-Ttr-128572	Tursiops truncatus	84.88	0.00e+00	1005.00
IUUC-Xtr-132103	Xenopus tropicalis	73.98	0.00e+00	941.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence