iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050200

Ensembl Protein ID

ENSLACP00000014568.1

UniProt Accession

H3AY47; H3AY47_LATCH

Genbank Protein ID

ENSLACP00000014568

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01033320

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000012823.1	ENSLACT00000014668.1	ENSLACP00000014568.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.00e-58	190.7	742	776
UBD/Beta-Prp	6.90e-98	327.7	611	784

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gH++ v+ + f +d ++l+s+s+Dgt+k+WD+ + 
   Q: 742  GHEGYVNHCLFsPDdHYLASCSNDGTLKLWDVESA 776
           8********9**777****************9876 PP

UBD/Beta-Prp

   S: 89   tlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltg 177
           +++ h+d+v+   fs +g+k++s ++drt+++ + etg+ l    + hd+ v c +++pd++l++++++D++v++W+++tg+l++t ++
   Q: 611  VVRPHTDTVYHACFSSDGQKIASCGADRTLQILKSETGERLL-EINDHDDEVLCCAFSPDNKLVATCTTDKKVKVWNSETGNLIKTYEE 698
           5778**************************************.77888888999999999***************************99 PP
   S: 178  ghtdsvyslsfdsng..kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlql 262
            h ++v++ +f+ ++    l+++s+d+++klwd+ +++c +tl gh+  v+   fsp+d++l+s+s Dg++++Wd++s + +k++  
   Q: 699  -HAEQVNHCEFNNTSekILLATCSDDTYLKLWDINEKHCRNTLFGHEGYVNHCLFSPDDHYLASCSNDGTLKLWDVESANEWKSIDV 784
           .*********99988667789***********************************************************9999865 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

SRMDEKARSC LLRHRAALER DIKTSYIIDH MISDEVLTLE EEQNVKTLST QRDRGVRLIN 60
IILRKDNYTY ISFYNALLHE GYKDLAALLQ DCIPIISPLM SNSKDDNTPY VQARLCEGGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGGCTTTT CTCAGCAGTG CATTTATTTA TTTAGCTATT TAATATAGTT ATCATATAAT 60
CCACTCTTCT TCTTTCTTTC TTTGCAGCTG GAAGAGGCAG TTCAGAATTG TGCAGGGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0097190--P:apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	65.73	0.00e+00	1632.00
IUUC-Apl-004201	Anas platyrhynchos	65.42	0.00e+00	1621.00
IUUC-Aca-004638	Anolis carolinensis	63.58	0.00e+00	1620.00
IUUC-Afu-008928	Aspergillus fumigatus	27.96	5.00e-60	226.00
IUUC-Ani-009285	Aspergillus nidulans	29.64	2.00e-68	254.00
IUUC-Ame-011062	Astyanax mexicanus	57.58	0.00e+00	1412.00
IUUC-Bta-012865	Bos taurus	65.39	0.00e+00	1664.00
IUUC-Cja-018815	Callithrix jacchus	60.69	0.00e+00	1469.00
IUUC-Cfa-020222	Canis familiaris	61.93	0.00e+00	1515.00
IUUC-Cpo-021524	Cavia porcellus	64.11	0.00e+00	1627.00
IUUC-Csa-023861	Chlorocebus sabaeus	65.25	0.00e+00	1639.00
IUUC-Cho-024484	Choloepus hoffmanni	53.97	0.00e+00	764.00
IUUC-Dre-028006	Danio rerio	56.67	0.00e+00	1303.00
IUUC-Dno-029591	Dasypus novemcinctus	65.92	0.00e+00	1667.00
IUUC-Dor-030237	Dipodomys ordii	50.68	0.00e+00	657.00
IUUC-Ete-032620	Echinops telfairi	63.39	0.00e+00	819.00
IUUC-Eca-033569	Equus caballus	65.78	0.00e+00	1636.00
IUUC-Eeu-035354	Erinaceus europaeus	61.95	8.00e-112	398.00
IUUC-Fca-036337	Felis catus	64.95	0.00e+00	1650.00
IUUC-Fal-037077	Ficedula albicollis	64.95	0.00e+00	1607.00
IUUC-Gmo-039687	Gadus morhua	52.12	0.00e+00	966.00
IUUC-Gga-040299	Gallus gallus	64.78	0.00e+00	1643.00
IUUC-Gac-041762	Gasterosteus aculeatus	54.06	0.00e+00	1293.00
IUUC-Ggo-045563	Gorilla gorilla	65.31	0.00e+00	1642.00
IUUC-Hsa-046771	Homo sapiens	65.25	0.00e+00	1637.00
IUUC-Loc-052090	Lepisosteus oculatus	63.50	0.00e+00	1565.00
IUUC-Laf-053861	Loxodonta africana	65.37	0.00e+00	1646.00
IUUC-Mcc-055543	Macaca mulatta	65.42	0.00e+00	1645.00
IUUC-Meu-056688	Macropus eugenii	64.84	0.00e+00	1599.00
IUUC-Mga-059243	Meleagris gallopavo	65.31	0.00e+00	1652.00
IUUC-Mmr-061134	Microcebus murinus	61.83	0.00e+00	1387.00
IUUC-Mdo-062913	Monodelphis domestica	64.34	0.00e+00	1608.00
IUUC-Mmu-063811	Mus musculus	64.42	0.00e+00	1634.00
IUUC-Mpu-066780	Mustela putorius furo	65.64	0.00e+00	1630.00
IUUC-Mlu-067276	Myotis lucifugus	65.42	0.00e+00	1654.00
IUUC-Nfi-068459	Neosartorya fischeri	28.40	1.00e-60	229.00
IUUC-Nle-069129	Nomascus leucogenys	64.92	0.00e+00	1631.00
IUUC-Opr-071007	Ochotona princeps	50.99	0.00e+00	759.00
IUUC-Ont-071348	Oreochromis niloticus	57.79	0.00e+00	1443.00
IUUC-Oan-072717	Ornithorhynchus anatinus	67.39	0.00e+00	1702.00
IUUC-Ocu-074286	Oryctolagus cuniculus	64.48	0.00e+00	1365.00
IUUC-Ola-086895	Oryzias latipes	52.84	0.00e+00	1299.00
IUUC-Oga-088678	Otolemur garnettii	64.92	0.00e+00	1636.00
IUUC-Oar-089359	Ovis aries	65.67	0.00e+00	1664.00
IUUC-Ptr-091062	Pan troglodytes	65.17	0.00e+00	1637.00
IUUC-Pan-092528	Papio anubis	69.60	0.00e+00	1067.00
IUUC-Psi-093430	Pelodiscus sinensis	66.72	0.00e+00	1677.00
IUUC-Pma-094690	Petromyzon marinus	41.50	2.00e-156	546.00
IUUC-Pfo-097204	Poecilia formosa	56.34	0.00e+00	1395.00
IUUC-Pab-097690	Pongo abelii	65.59	0.00e+00	1648.00
IUUC-Pca-100778	Procavia capensis	49.88	0.00e+00	778.00
IUUC-Pva-102870	Pteropus vampyrus	63.79	0.00e+00	1472.00
IUUC-Rno-104889	Rattus norvegicus	64.09	0.00e+00	1604.00
IUUC-Sha-107465	Sarcophilus harrisii	64.29	0.00e+00	1628.00
IUUC-Sar-113268	Sorex araneus	64.10	6.00e-139	488.00
IUUC-Ssc-115654	Sus scrofa	65.00	0.00e+00	1652.00
IUUC-Tgu-117302	Taeniopygia guttata	65.12	0.00e+00	1621.00
IUUC-Tru-118363	Takifugu rubripes	57.87	0.00e+00	1429.00
IUUC-Tsy-119007	Tarsius syrichta	64.23	0.00e+00	1610.00
IUUC-Tni-120910	Tetraodon nigroviridis	56.37	0.00e+00	1428.00
IUUC-Tbe-127413	Tupaia belangeri	54.24	0.00e+00	934.00
IUUC-Ttr-129213	Tursiops truncatus	63.40	0.00e+00	1519.00
IUUC-Vpa-130146	Vicugna pacos	59.41	0.00e+00	1077.00
IUUC-Xtr-132559	Xenopus tropicalis	59.00	0.00e+00	1462.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence