iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025157

UUCD1 version

UUC-CiI-00031

Ensembl Protein ID

ENSCINP00000006212.3

UniProt Accession

F6PPP8; F6PPP8_CIOIN

Protein Name

Uncharacterized protein

Gene Name

LOC100176211

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000003020.3	ENSCINT00000006175.3	ENSCINP00000006175.3
ENSCING00000003020.3	ENSCINT00000006212.3	ENSCINP00000006212.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-132	442.3	539	868

Active Site

Position(s)	Description	Evidence
838	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef +E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sg++n++h+++F+f+Gr+ g+a+++g+lld+++
   Q: 539  FLKSRLWIEFNKEKGLDYGGVAREWFYLLSKEMFNPYYGLFEYSATDNYTLQINPNSGMCNEDHFDWFRFIGRVAGMAVYHGKLLDAFF 627
           689************************************************************************************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++lgk+++l d+e+vd+e+y+slk+i+en   d ++l  dl f+v+ee++g++k++eLkpgG++i+V+neNk+eY++lv+++r
   Q: 628  IRPFYKMMLGKPITLRDMESVDSEYYNSLKWILEN---DPTDL--DLCFTVDEELFGQMKVNELKPGGADIKVNNENKREYIQLVIKWR 711
           *********************************99...78886..5556678************************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++++eq+++f +Gfne+ip +l+++F+e+e+ell+cG  ++dv+d++++t+ykg+y++++ +iqwFw+++  ++ e r +fLqFvTg
   Q: 712  FVSRVQEQMKSFLQGFNELIPSNLVKIFDENEVELLMCGLGDVDVNDWRRNTNYKGDYSANHIVIQWFWRAVLLMDPELRVRFLQFVTG 800
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gf el     p+lf+i+k++++++lP+++TCfn+L+LP+Y+s e+l++kLl+Aie+t+gFe
   Q: 801  TSRVPMNGFGELWgsngPQLFTIEKWGTPEKLPRAHTCFNRLDLPPYKSFEELRKKLLLAIESTQGFE 868
           *******************************************************************8 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

RSLSEEEGSR LVRIQVLSGH NLAKKDIFGA SDPYVSVSLY KPKRSASGSS KTITCVNTKT 60
KKRTLNPSWN EKFLFRVVPR ENRLLFEVFD ENRLTRDDFL GQVDIPINAS YISNDDETGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGATGTTC GTAGTTTAAG TGAAGAAGTG TTGGGCTGTG GTGTTTATGA GGTTTGGGGG 60
TGGATACATT GTAACATGAT AGTTTGTATC GCATTGCAAC TATAAATAAT TGTATTGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	56.27	0.00e+00	880.00
IUUC-Apl-003886	Anas platyrhynchos	64.52	0.00e+00	778.00
IUUC-Aca-004744	Anolis carolinensis	61.46	0.00e+00	732.00
IUUC-Aor-010053	Aspergillus oryzae	56.38	7.00e-100	355.00
IUUC-Ame-011138	Astyanax mexicanus	73.77	0.00e+00	751.00
IUUC-Bta-012679	Bos taurus	61.93	0.00e+00	762.00
IUUC-Cel-018564	Caenorhabditis elegans	41.47	7.00e-171	592.00
IUUC-Cja-019034	Callithrix jacchus	67.14	0.00e+00	796.00
IUUC-Cfa-020258	Canis familiaris	66.37	0.00e+00	789.00
IUUC-Cpo-021671	Cavia porcellus	54.63	0.00e+00	949.00
IUUC-Csa-023334	Chlorocebus sabaeus	66.96	0.00e+00	778.00
IUUC-Cho-024832	Choloepus hoffmanni	76.27	7.00e-167	579.00
IUUC-Csv-026098	Ciona savignyi	76.38	0.00e+00	857.00
IUUC-Dre-027770	Danio rerio	71.31	0.00e+00	744.00
IUUC-Dno-029159	Dasypus novemcinctus	63.52	0.00e+00	734.00
IUUC-Dor-030138	Dipodomys ordii	51.73	0.00e+00	858.00
IUUC-Dse-031241	Dothistroma septosporum	46.03	3.00e-149	521.00
IUUC-Dme-032166	Drosophila melanogaster	64.99	0.00e+00	718.00
IUUC-Ete-032409	Echinops telfairi	53.14	0.00e+00	708.00
IUUC-Eca-033441	Equus caballus	67.08	0.00e+00	766.00
IUUC-Eeu-035247	Erinaceus europaeus	61.65	0.00e+00	763.00
IUUC-Fca-036384	Felis catus	55.41	0.00e+00	867.00
IUUC-Fal-037547	Ficedula albicollis	55.60	0.00e+00	953.00
IUUC-Gmo-039679	Gadus morhua	64.77	0.00e+00	758.00
IUUC-Gga-040524	Gallus gallus	67.97	0.00e+00	769.00
IUUC-Gac-042607	Gasterosteus aculeatus	55.21	0.00e+00	947.00
IUUC-Ggo-045332	Gorilla gorilla	61.45	0.00e+00	762.00
IUUC-Hsa-046479	Homo sapiens	66.55	0.00e+00	789.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	71.63	0.00e+00	726.00
IUUC-Lch-050445	Latimeria chalumnae	65.66	0.00e+00	780.00
IUUC-Loc-052645	Lepisosteus oculatus	67.61	0.00e+00	777.00
IUUC-Laf-053638	Loxodonta africana	53.33	0.00e+00	843.00
IUUC-Mcc-055585	Macaca mulatta	67.14	0.00e+00	788.00
IUUC-Meu-056897	Macropus eugenii	77.70	1.00e-140	493.00
IUUC-Mga-059362	Meleagris gallopavo	66.61	0.00e+00	779.00
IUUC-Mmr-061061	Microcebus murinus	55.35	0.00e+00	868.00
IUUC-Mdo-062173	Monodelphis domestica	60.41	0.00e+00	754.00
IUUC-Mmu-063318	Mus musculus	53.27	0.00e+00	864.00
IUUC-Mpu-066567	Mustela putorius furo	56.07	0.00e+00	976.00
IUUC-Mlu-068148	Myotis lucifugus	55.30	0.00e+00	864.00
IUUC-Nle-069225	Nomascus leucogenys	66.79	0.00e+00	791.00
IUUC-Opr-071044	Ochotona princeps	61.65	0.00e+00	763.00
IUUC-Ont-071664	Oreochromis niloticus	63.29	0.00e+00	740.00
IUUC-Oan-073019	Ornithorhynchus anatinus	55.09	0.00e+00	893.00
IUUC-Ocu-074409	Oryctolagus cuniculus	56.01	0.00e+00	881.00
IUUC-Ola-087467	Oryzias latipes	61.91	0.00e+00	744.00
IUUC-Oga-088460	Otolemur garnettii	62.05	0.00e+00	761.00
IUUC-Oar-089797	Ovis aries	56.37	0.00e+00	904.00
IUUC-Ptr-091629	Pan troglodytes	66.55	0.00e+00	789.00
IUUC-Pan-092284	Papio anubis	62.11	0.00e+00	764.00
IUUC-Psi-093618	Pelodiscus sinensis	67.20	0.00e+00	774.00
IUUC-Pma-094364	Petromyzon marinus	72.35	0.00e+00	726.00
IUUC-Pfo-097145	Poecilia formosa	64.37	0.00e+00	749.00
IUUC-Pab-098394	Pongo abelii	66.61	0.00e+00	778.00
IUUC-Pca-100568	Procavia capensis	58.76	0.00e+00	694.00
IUUC-Pva-102354	Pteropus vampyrus	62.62	0.00e+00	766.00
IUUC-Rno-106095	Rattus norvegicus	52.73	0.00e+00	859.00
IUUC-Sha-107482	Sarcophilus harrisii	61.39	0.00e+00	754.00
IUUC-Ssc-115950	Sus scrofa	68.78	0.00e+00	708.00
IUUC-Tgu-117474	Taeniopygia guttata	56.46	0.00e+00	962.00
IUUC-Tru-117675	Takifugu rubripes	55.90	0.00e+00	970.00
IUUC-Tsy-119492	Tarsius syrichta	61.17	0.00e+00	756.00
IUUC-Tni-119993	Tetraodon nigroviridis	65.40	0.00e+00	749.00
IUUC-Tbe-127408	Tupaia belangeri	61.40	0.00e+00	681.00
IUUC-Ttr-128235	Tursiops truncatus	71.84	0.00e+00	746.00
IUUC-Vpa-130503	Vicugna pacos	66.37	0.00e+00	750.00
IUUC-Xtr-132859	Xenopus tropicalis	61.01	0.00e+00	759.00
IUUC-Xma-133630	Xiphophorus maculatus	62.07	0.00e+00	742.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence