iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062197

Ensembl Protein ID

ENSMODP00000007575.2

UniProt Accession

F7EIE5; F7EIE5_MONDO

Protein Name

Presenilin

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000006114.3	ENSMODT00000007728.3	ENSMODP00000007575.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	2.20e-07	31.0	282	317

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavn 37
           +eta+e++++iFP+l+ys+ +v+ + +++ ++++ +
   Q: 282  VETAQERNEPIFPALIYSSAMVWTVGMAKVDSPTKG 317
           89**************************99998855 PP

Organism

Monodelphis domestica

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNSDSE EEVCNERTSL MSTESPPARS YHEGICTEER DKEIQEKRRG SPCHHGDADQ 60
CTPDSRGSTR SSSLEEEEEE EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVRFYTEKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTGAAATGG CACCAGTTGA GAAACCTTAG TCATATATAC TAGTTACCCA GGTCGGAGGT 60
CCCCGCAACA CTGGAGCTTC TGAATCCCCC TCAGTAACCT ACTGCAAGGA GGAAGCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

KEGG

mdo:100026453

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	73.04	2.00e-140	492.00
IUUC-Apl-003959	Anas platyrhynchos	77.71	2.00e-164	572.00
IUUC-Aca-005160	Anolis carolinensis	77.56	1.00e-166	579.00
IUUC-Ame-010686	Astyanax mexicanus	80.53	8.00e-137	479.00
IUUC-Bta-013097	Bos taurus	79.91	1.00e-165	575.00
IUUC-Cja-018824	Callithrix jacchus	79.22	1.00e-164	572.00
IUUC-Cfa-020253	Canis familiaris	79.35	3.00e-169	588.00
IUUC-Cpo-021401	Cavia porcellus	80.74	3.00e-168	584.00
IUUC-Csa-023369	Chlorocebus sabaeus	80.52	3.00e-169	587.00
IUUC-Dre-028526	Danio rerio	69.25	3.00e-144	504.00
IUUC-Dor-031127	Dipodomys ordii	77.78	3.00e-163	568.00
IUUC-Ete-033081	Echinops telfairi	74.31	4.00e-78	285.00
IUUC-Eca-034387	Equus caballus	80.00	1.00e-161	562.00
IUUC-Eeu-034846	Erinaceus europaeus	65.51	2.00e-114	405.00
IUUC-Fca-035396	Felis catus	79.61	6.00e-176	610.00
IUUC-Fal-037457	Ficedula albicollis	77.51	2.00e-164	572.00
IUUC-Gmo-038550	Gadus morhua	69.44	1.00e-121	429.00
IUUC-Gga-040706	Gallus gallus	78.35	1.00e-164	572.00
IUUC-Gac-042511	Gasterosteus aculeatus	67.81	1.00e-128	453.00
IUUC-Ggo-045338	Gorilla gorilla	80.79	3.00e-169	587.00
IUUC-Hsa-046455	Homo sapiens	80.79	4.00e-169	587.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	80.95	7.00e-169	586.00
IUUC-Lch-049638	Latimeria chalumnae	69.49	7.00e-149	520.00
IUUC-Loc-052427	Lepisosteus oculatus	74.08	1.00e-157	549.00
IUUC-Laf-053758	Loxodonta africana	76.86	4.00e-172	597.00
IUUC-Mcc-054755	Macaca mulatta	81.00	8.00e-170	590.00
IUUC-Mtr-058392	Medicago truncatula	34.39	2.00e-29	123.00
IUUC-Mmr-060890	Microcebus murinus	79.87	3.00e-167	581.00
IUUC-Mmu-063823	Mus musculus	80.09	8.00e-170	589.00
IUUC-Mac-064858	Musa acuminata	41.95	1.00e-22	100.00
IUUC-Mpu-066181	Mustela putorius furo	79.57	3.00e-170	591.00
IUUC-Nle-069596	Nomascus leucogenys	78.27	1.00e-154	539.00
IUUC-Opr-070344	Ochotona princeps	78.18	2.00e-171	594.00
IUUC-Ont-071867	Oreochromis niloticus	71.05	4.00e-135	474.00
IUUC-Oan-073378	Ornithorhynchus anatinus	79.17	9.00e-164	569.00
IUUC-Ocu-074652	Oryctolagus cuniculus	80.17	3.00e-164	571.00
IUUC-Oin-079244	Oryza indica	60.49	3.00e-16	80.10
IUUC-Oni-082057	Oryza nivara	60.49	3.00e-16	79.70
IUUC-Opu-084176	Oryza punctata	60.49	2.00e-16	80.10
IUUC-Ola-086707	Oryzias latipes	70.82	6.00e-102	363.00
IUUC-Oga-088560	Otolemur garnettii	79.39	6.00e-161	560.00
IUUC-Oar-089200	Ovis aries	80.35	1.00e-165	576.00
IUUC-Ptr-090569	Pan troglodytes	80.57	2.00e-168	585.00
IUUC-Pan-091742	Papio anubis	81.00	6.00e-170	590.00
IUUC-Pma-094612	Petromyzon marinus	76.84	1.00e-127	449.00
IUUC-Ppa-095431	Physcomitrella patens	33.03	2.00e-24	106.00
IUUC-Pab-098531	Pongo abelii	80.52	3.00e-169	587.00
IUUC-Pca-101120	Procavia capensis	77.34	9.00e-158	549.00
IUUC-Pva-102934	Pteropus vampyrus	75.11	3.00e-163	568.00
IUUC-Rno-106052	Rattus norvegicus	78.88	2.00e-172	598.00
IUUC-Sha-106876	Sarcophilus harrisii	96.32	0.00e+00	759.00
IUUC-Sit-110624	Setaria italica	58.02	7.00e-16	78.60
IUUC-Ssc-115380	Sus scrofa	81.05	1.00e-169	589.00
IUUC-Tgu-117280	Taeniopygia guttata	77.73	5.00e-166	577.00
IUUC-Tbe-127632	Tupaia belangeri	77.68	1.00e-139	489.00
IUUC-Ttr-129008	Tursiops truncatus	80.35	5.00e-165	573.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence