iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-064176

UUCD1 version

UUC-MuM-00890

Ensembl Protein ID

ENSMUSP00000104837.1

UniProt Accession

Q9ET26; Q3UFU8; Q8K5A2; RN114_MOUSE

Genbank Protein ID

AAG01141.2; AAM22210.1; BAC40355.1; BAE23870.1; BAE28461.1; BAE28527.1; BAE29295.1; BAE29420.1; BAE31418.1; BAE32006.1; BAE35398.1; AAH54416.1; AAH85146.1

Protein Name

E3 ubiquitin-protein ligase RNF114; RING finger protein 114; RING-type E3 ubiquitin transferase RNF114; Zinc finger protein 228; Zinc finger protein 313

Genbank Nucleotide ID

AF282919; AF502145; AK088441; AK139030; AK148290; AK148392; AK150086; AK150263; AK152687; AK153452; AK159818; BC054416; BC085146

Gene Name

Rnf114; Zfp228; Zfp313; Znf228; Znf313

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000006418.17	ENSMUST00000109214.7	ENSMUSP00000104837.1
ENSMUSG00000006418.17	ENSMUST00000127939.1	ENSMUSP00000138430.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.90e-08	34.8	25	73
E3 activity/RING/RING	2.00e-06	29.3	30	69

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplt 51
           ++ f Cp+ le+++ Pv +p+G+++  ++++++l+ ++  c v+r+ l+
   Q: 25   LSRFTCPVCLEVFEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALA 73
           678******************************************9986 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle f++ p+ +pCgHvf+  Clq       ++ k+  C +Cr
   Q: 30   CPVCLEVFEK-PVQVPCGHVFCSACLQEC-----LKPKKPVCGVCR 69
           **********.999************555.....499999*****8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

Protein Sequence
(Fasta)

MAAAQPESRD GAAQSAKPAS ETDPLSRFTC PVCLEVFEKP VQVPCGHVFC SACLQECLKP 60
KKPVCGVCRS ALAPGVRAVE LERQIESIET SCHGCRKNFI LSKIRAHVTS CSKYQNYIME 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCCAGTG CTGCGACCAG CCGCCCGGAG CCGCCGCGGC CGCGGGACAG AGCCGAGGGC 60
CTGGCCGGTG ACAGCGCGCG CAGGGGTCCA CCCTCCTGCC CCACCCGCAC TCACCCACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR027370--Znf-RING_LisH
IPR013087--Znf_C2H2_type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00355--ZnF_C2H2

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030154--P:cell differentiation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0007283--P:spermatogenesis

KEGG

mmu:81018

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002315	Ailuropoda melanoleuca	89.43	6.00e-124	436.00
IUUC-Apl-004036	Anas platyrhynchos	75.69	5.00e-82	296.00
IUUC-Aca-004569	Anolis carolinensis	71.86	7.00e-99	352.00
IUUC-Bta-013345	Bos taurus	89.47	4.00e-124	436.00
IUUC-Cja-019919	Callithrix jacchus	90.75	6.00e-124	436.00
IUUC-Cfa-021164	Canis familiaris	89.87	4.00e-124	436.00
IUUC-Cpo-022051	Cavia porcellus	79.48	2.00e-111	394.00
IUUC-Csa-023956	Chlorocebus sabaeus	92.75	1.00e-116	412.00
IUUC-Dre-027499	Danio rerio	52.74	4.00e-66	244.00
IUUC-Dno-029437	Dasypus novemcinctus	87.77	6.00e-120	422.00
IUUC-Dor-030428	Dipodomys ordii	74.45	2.00e-100	358.00
IUUC-Ete-032855	Echinops telfairi	72.93	1.00e-87	315.00
IUUC-Eca-034236	Equus caballus	92.82	3.00e-101	360.00
IUUC-Eeu-034875	Erinaceus europaeus	93.62	2.00e-106	377.00
IUUC-Fca-036017	Felis catus	92.45	6.00e-120	422.00
IUUC-Fal-037133	Ficedula albicollis	74.59	6.00e-83	300.00
IUUC-Gga-040752	Gallus gallus	72.27	3.00e-95	340.00
IUUC-Ggo-044654	Gorilla gorilla	91.60	5.00e-72	263.00
IUUC-Hsa-046280	Homo sapiens	93.24	6.00e-117	412.00
IUUC-Itr-048594	Ictidomys tridecemlineatus	91.40	2.00e-101	361.00
IUUC-Lch-050028	Latimeria chalumnae	61.90	2.00e-79	288.00
IUUC-Loc-051797	Lepisosteus oculatus	57.07	4.00e-69	254.00
IUUC-Laf-054248	Loxodonta africana	92.27	4.00e-101	359.00
IUUC-Mcc-054724	Macaca mulatta	92.75	1.00e-116	412.00
IUUC-Meu-056464	Macropus eugenii	59.12	2.00e-51	194.00
IUUC-Mga-059403	Meleagris gallopavo	75.94	2.00e-61	227.00
IUUC-Mmr-061582	Microcebus murinus	93.37	6.00e-103	365.00
IUUC-Mdo-062106	Monodelphis domestica	77.73	3.00e-98	350.00
IUUC-Mpu-066083	Mustela putorius furo	89.87	4.00e-125	439.00
IUUC-Mlu-067060	Myotis lucifugus	90.82	3.00e-114	404.00
IUUC-Nle-069353	Nomascus leucogenys	93.72	2.00e-107	381.00
IUUC-Opr-070916	Ochotona princeps	85.90	4.00e-119	420.00
IUUC-Ont-072284	Oreochromis niloticus	55.71	3.00e-72	264.00
IUUC-Oan-072858	Ornithorhynchus anatinus	75.14	5.00e-82	296.00
IUUC-Ocu-074471	Oryctolagus cuniculus	94.06	4.00e-116	410.00
IUUC-Oin-079762	Oryza indica	52.17	2.00e-09	57.00
IUUC-Olo-081000	Oryza longistaminata	52.17	1.00e-09	56.60
IUUC-Ola-087569	Oryzias latipes	53.67	9.00e-73	266.00
IUUC-Oga-089164	Otolemur garnettii	91.94	1.00e-118	418.00
IUUC-Oar-089436	Ovis aries	89.04	1.00e-124	438.00
IUUC-Ptr-090945	Pan troglodytes	93.24	6.00e-117	412.00
IUUC-Pan-092765	Papio anubis	92.75	1.00e-116	412.00
IUUC-Psi-093593	Pelodiscus sinensis	74.47	4.00e-63	233.00
IUUC-Pfo-096157	Poecilia formosa	52.47	1.00e-69	256.00
IUUC-Pab-098509	Pongo abelii	92.34	2.00e-117	414.00
IUUC-Pca-100293	Procavia capensis	88.12	4.00e-105	373.00
IUUC-Pva-102556	Pteropus vampyrus	88.11	5.00e-121	426.00
IUUC-Rno-105634	Rattus norvegicus	96.94	2.00e-123	434.00
IUUC-Sha-107052	Sarcophilus harrisii	78.85	8.00e-92	329.00
IUUC-Sja-107944	Schizosaccharomyces japonicus	37.88	3.00e-08	52.40
IUUC-Sar-113680	Sorex araneus	91.16	1.00e-90	325.00
IUUC-Ssc-115451	Sus scrofa	92.27	5.00e-102	362.00
IUUC-Tgu-116515	Taeniopygia guttata	74.86	7.00e-83	299.00
IUUC-Tru-117712	Takifugu rubripes	55.50	4.00e-73	267.00
IUUC-Tsy-119419	Tarsius syrichta	92.82	6.00e-102	362.00
IUUC-Tni-119774	Tetraodon nigroviridis	56.88	1.00e-72	265.00
IUUC-Tbe-127924	Tupaia belangeri	85.84	2.00e-112	398.00
IUUC-Ttr-128721	Tursiops truncatus	88.99	2.00e-123	434.00
IUUC-Vpa-130175	Vicugna pacos	65.65	3.00e-81	294.00
IUUC-Xtr-131851	Xenopus tropicalis	56.31	7.00e-73	266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence