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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046025
UUCD1 version UUC-HoS-00412
Ensembl Protein ID ENSP00000273963.5
UniProt Accession Q9P2G9; Q53XA3; Q6N018; KLHL8_HUMAN
Genbank Protein ID BAA92616.2; CAE45843.1; CAE45855.1; EAX05982.1; AAH41384.1
Protein Name Kelch-like protein 8
Genbank Nucleotide ID AB037799; BX640727; BX640744; AC092658; BC041384
Gene Name KLHL8; KIAA1378
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145332.13 ENST00000273963.9 ENSP00000273963.5
ENSG00000145332.13 ENST00000498875.6 ENSP00000426451.1
ENSG00000145332.13 ENST00000425278.6 ENSP00000408854.2
ENSG00000145332.13 ENST00000506985.5 ENSP00000426361.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 19158078
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.00e-16 62.7 67 132
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 3.30e-10 39.1 166 197
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l+vg + +++hk+vLa   ++F+a+fl+e+ e k +  +ei+d + ++ ++l+kF+Y+++l++
   Q: 67   CDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAK-QTLIEIRDFDGDAIEDLVKFVYSSRLTL 132
           9************************************9.*************************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Ncl++++fA+ ++  dL+d a+ ++++hF+
   Q: 166  PSNCLAVRAFAESHNRIDLMDMADQYACDHFT 197
           89*****************************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.
Protein Sequence
(Fasta)
MASDSMSSKQ ARNHITKGKR QQQHQQIKNR SSISDGDGED SFIFEANEAW KDFHGSLLRF 60
YENGELCDVT LKVGSKLISC HKLVLACVIP YFRAMFLSEM AEAKQTLIEI RDFDGDAIED 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046025|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGATGCTGTC ATTTTCAGAA GAAGCTGATG TAAATGCCTC TACAACCTAA AGCCCAGGTG 60
AGCTATGTTG CCTTGGTTTG ATTATCTAAC GATTCCTTAA TCTAACATTG CAATAAGACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046025|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030605--KLHL8
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:57563
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001443 Ailuropoda melanoleuca 97.58 0.00e+00 1243.00
IUUC-Atr-002726 Amborella trichopoda 35.48 6.00e-43 169.00
IUUC-Apl-003978 Anas platyrhynchos 89.53 0.00e+00 1162.00
IUUC-Aca-004958 Anolis carolinensis 85.35 0.00e+00 1094.00
IUUC-Ame-011139 Astyanax mexicanus 82.75 0.00e+00 1067.00
IUUC-Bta-013142 Bos taurus 95.97 0.00e+00 1224.00
IUUC-Bdi-014143 Brachypodium distachyon 38.46 2.00e-42 167.00
IUUC-Bol-015710 Brassica oleracea 25.42 3.00e-11 62.80
IUUC-Cel-018551 Caenorhabditis elegans 42.45 1.00e-130 460.00
IUUC-Cja-019650 Callithrix jacchus 98.23 0.00e+00 1276.00
IUUC-Cfa-021046 Canis familiaris 97.90 0.00e+00 1247.00
IUUC-Cpo-022445 Cavia porcellus 93.55 0.00e+00 1167.00
IUUC-Csa-023642 Chlorocebus sabaeus 99.35 0.00e+00 1289.00
IUUC-Cho-025012 Choloepus hoffmanni 79.03 0.00e+00 889.00
IUUC-Dre-027723 Danio rerio 81.76 0.00e+00 1063.00
IUUC-Dno-028964 Dasypus novemcinctus 96.10 0.00e+00 1031.00
IUUC-Dor-030899 Dipodomys ordii 83.11 1.00e-136 480.00
IUUC-Ete-032815 Echinops telfairi 92.90 0.00e+00 1212.00
IUUC-Eca-034162 Equus caballus 96.77 0.00e+00 1213.00
IUUC-Eeu-034660 Erinaceus europaeus 94.03 0.00e+00 1200.00
IUUC-Fca-035659 Felis catus 97.90 0.00e+00 1248.00
IUUC-Fal-037619 Ficedula albicollis 90.48 0.00e+00 1177.00
IUUC-Gmo-038546 Gadus morhua 84.59 0.00e+00 1053.00
IUUC-Gga-040770 Gallus gallus 90.18 0.00e+00 1142.00
IUUC-Gac-042557 Gasterosteus aculeatus 79.35 0.00e+00 1045.00
IUUC-Ggo-044741 Gorilla gorilla 99.84 0.00e+00 1293.00
IUUC-Itr-048541 Ictidomys tridecemlineatus 97.63 0.00e+00 1107.00
IUUC-Loc-052834 Lepisosteus oculatus 81.83 0.00e+00 1012.00
IUUC-Laf-054513 Loxodonta africana 96.45 0.00e+00 1229.00
IUUC-Mcc-054707 Macaca mulatta 99.19 0.00e+00 1285.00
IUUC-Meu-056779 Macropus eugenii 90.51 0.00e+00 1164.00
IUUC-Mtr-058180 Medicago truncatula 31.54 1.00e-35 145.00
IUUC-Mga-059676 Meleagris gallopavo 89.69 0.00e+00 1139.00
IUUC-Mmr-061359 Microcebus murinus 95.81 0.00e+00 1220.00
IUUC-Mdo-062527 Monodelphis domestica 89.09 0.00e+00 1160.00
IUUC-Mmu-063112 Mus musculus 92.37 0.00e+00 1212.00
IUUC-Mac-064682 Musa acuminata 35.50 2.00e-41 164.00
IUUC-Mpu-065800 Mustela putorius furo 97.10 0.00e+00 1238.00
IUUC-Mlu-067536 Myotis lucifugus 96.59 0.00e+00 1185.00
IUUC-Nle-069397 Nomascus leucogenys 99.68 0.00e+00 1292.00
IUUC-Opr-070599 Ochotona princeps 94.92 0.00e+00 1021.00
IUUC-Ont-072580 Oreochromis niloticus 82.33 0.00e+00 1059.00
IUUC-Oan-073180 Ornithorhynchus anatinus 92.26 0.00e+00 1181.00
IUUC-Ocu-074026 Oryctolagus cuniculus 95.97 0.00e+00 1206.00
IUUC-Ola-086776 Oryzias latipes 80.65 0.00e+00 1026.00
IUUC-Oga-088651 Otolemur garnettii 96.78 0.00e+00 1225.00
IUUC-Oar-089567 Ovis aries 94.84 0.00e+00 1201.00
IUUC-Ptr-091564 Pan troglodytes 99.84 0.00e+00 1293.00
IUUC-Pan-092578 Papio anubis 99.35 0.00e+00 1289.00
IUUC-Psi-093635 Pelodiscus sinensis 88.94 0.00e+00 1104.00
IUUC-Pma-094660 Petromyzon marinus 61.64 0.00e+00 761.00
IUUC-Pfo-097507 Poecilia formosa 80.03 0.00e+00 989.00
IUUC-Pab-098025 Pongo abelii 99.84 0.00e+00 1293.00
IUUC-Pca-101046 Procavia capensis 86.85 0.00e+00 633.00
IUUC-Ppe-101154 Prunus persica 31.50 1.00e-37 151.00
IUUC-Pva-102359 Pteropus vampyrus 97.95 0.00e+00 909.00
IUUC-Rno-105750 Rattus norvegicus 92.59 0.00e+00 1191.00
IUUC-Sha-107513 Sarcophilus harrisii 92.11 0.00e+00 1199.00
IUUC-Sly-111482 Solanum lycopersicum 31.13 1.00e-40 161.00
IUUC-Stu-112032 Solanum tuberosum 32.30 5.00e-42 166.00
IUUC-Sar-113616 Sorex araneus 70.99 5.00e-118 418.00
IUUC-Ssc-116205 Sus scrofa 96.49 0.00e+00 1034.00
IUUC-Tgu-117435 Taeniopygia guttata 90.65 0.00e+00 1170.00
IUUC-Tru-118709 Takifugu rubripes 80.86 0.00e+00 1057.00
IUUC-Tsy-119466 Tarsius syrichta 98.36 0.00e+00 1108.00
IUUC-Tni-119988 Tetraodon nigroviridis 80.56 0.00e+00 1048.00
IUUC-Tae-124761 Triticum aestivum 34.36 2.00e-38 154.00
IUUC-Tur-126089 Triticum urartu 33.48 1.00e-37 152.00
IUUC-Tbe-127704 Tupaia belangeri 96.35 0.00e+00 1066.00
IUUC-Ttr-128892 Tursiops truncatus 97.62 0.00e+00 925.00
IUUC-Vpa-130545 Vicugna pacos 97.27 0.00e+00 1045.00
IUUC-Xtr-132289 Xenopus tropicalis 83.68 0.00e+00 1035.00
Created Date 25-Jun-2017

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