iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097588

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

TRIM25

Genbank Nucleotide ID

ABGA01180543

Gene Name

TRIM25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000008249.2	ENSPPYT00000009642.2	ENSPPYP00000009268.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.90e-09	35.8	13	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle+fk+ p+++pCgH f+ +Cl + w     ++    +CP Cr
   Q: 13   CSICLEPFKE-PVTTPCGHNFCGSCLsETW----AVQGAPYLCPQCR 54
           ********99.*******************....8999999*****8 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAELCPLAEE LSCSICLEPF KEPVTTPCGH NFCGSCLSET WAVQGAPYLC PQCRAVYQAR 60
PQLHKNTVLC NVVEQFLQAD LAREPPTDGW TPPARASAPS PGAQVACDHC LKEAAVKTCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGGCTTCA GGGACTGCCC CCTCGGGCTA GGTTTCGTTT CCTCGGCTGC CTCGGAGTGC 60
GGGTGCAGCA GTCGCGTCCC GACCCCTGGG AGCGCCATGG CAGAGCTGTG CCCCCTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen

KEGG

pon:100440167

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	77.53	0.00e+00	962.00
IUUC-Apl-004101	Anas platyrhynchos	49.68	1.00e-164	573.00
IUUC-Aca-005025	Anolis carolinensis	49.21	3.00e-171	595.00
IUUC-Ame-011586	Astyanax mexicanus	26.00	3.00e-59	222.00
IUUC-Bta-012735	Bos taurus	74.17	0.00e+00	935.00
IUUC-Cja-019996	Callithrix jacchus	80.30	0.00e+00	710.00
IUUC-Cfa-020466	Canis familiaris	75.04	0.00e+00	961.00
IUUC-Cpo-021737	Cavia porcellus	70.46	0.00e+00	874.00
IUUC-Csa-023217	Chlorocebus sabaeus	93.97	0.00e+00	1145.00
IUUC-Cho-024346	Choloepus hoffmanni	50.50	4.00e-70	258.00
IUUC-Dre-028328	Danio rerio	25.68	1.00e-53	204.00
IUUC-Dno-030082	Dasypus novemcinctus	73.39	0.00e+00	932.00
IUUC-Dor-030335	Dipodomys ordii	52.85	9.00e-125	440.00
IUUC-Ete-032923	Echinops telfairi	69.39	0.00e+00	786.00
IUUC-Eca-033411	Equus caballus	74.77	0.00e+00	932.00
IUUC-Eeu-034656	Erinaceus europaeus	73.39	4.00e-163	568.00
IUUC-Fca-035371	Felis catus	77.04	0.00e+00	966.00
IUUC-Fal-037008	Ficedula albicollis	45.21	3.00e-155	542.00
IUUC-Gmo-038668	Gadus morhua	34.41	5.00e-103	368.00
IUUC-Gga-040608	Gallus gallus	47.43	1.00e-158	553.00
IUUC-Gac-041409	Gasterosteus aculeatus	52.20	2.00e-57	217.00
IUUC-Ggo-044518	Gorilla gorilla	95.09	0.00e+00	1139.00
IUUC-Hsa-045828	Homo sapiens	96.03	0.00e+00	1162.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	65.77	4.00e-136	478.00
IUUC-Lch-050478	Latimeria chalumnae	39.94	4.00e-70	259.00
IUUC-Loc-052864	Lepisosteus oculatus	36.11	4.00e-110	392.00
IUUC-Laf-054325	Loxodonta africana	77.45	4.00e-169	587.00
IUUC-Mcc-054920	Macaca mulatta	94.60	0.00e+00	1150.00
IUUC-Meu-056367	Macropus eugenii	73.41	3.00e-74	273.00
IUUC-Mga-059975	Meleagris gallopavo	49.45	3.00e-161	561.00
IUUC-Mmr-060748	Microcebus murinus	80.06	0.00e+00	987.00
IUUC-Mdo-062904	Monodelphis domestica	56.85	0.00e+00	681.00
IUUC-Mmu-063891	Mus musculus	72.60	0.00e+00	921.00
IUUC-Mpu-066473	Mustela putorius furo	76.40	0.00e+00	978.00
IUUC-Mlu-068185	Myotis lucifugus	74.53	0.00e+00	931.00
IUUC-Nle-070177	Nomascus leucogenys	96.19	0.00e+00	1164.00
IUUC-Opr-070558	Ochotona princeps	61.28	2.00e-143	502.00
IUUC-Ont-071368	Oreochromis niloticus	48.35	6.00e-53	202.00
IUUC-Ocu-074461	Oryctolagus cuniculus	67.79	9.00e-151	526.00
IUUC-Ola-087394	Oryzias latipes	29.40	6.00e-61	228.00
IUUC-Oga-088937	Otolemur garnettii	73.78	0.00e+00	924.00
IUUC-Oar-089781	Ovis aries	74.21	0.00e+00	625.00
IUUC-Ptr-090771	Pan troglodytes	96.03	0.00e+00	1160.00
IUUC-Pan-092830	Papio anubis	94.44	0.00e+00	1151.00
IUUC-Psi-093664	Pelodiscus sinensis	52.95	2.00e-177	615.00
IUUC-Pma-094147	Petromyzon marinus	28.13	1.00e-60	227.00
IUUC-Pfo-096528	Poecilia formosa	35.98	3.00e-57	216.00
IUUC-Pca-100890	Procavia capensis	74.67	3.00e-161	561.00
IUUC-Pva-102314	Pteropus vampyrus	81.04	0.00e+00	959.00
IUUC-Rno-105234	Rattus norvegicus	69.03	0.00e+00	887.00
IUUC-Sce-106362	Saccharomyces cerevisiae	43.48	3.00e-08	52.80
IUUC-Sha-106807	Sarcophilus harrisii	54.01	0.00e+00	647.00
IUUC-Sar-113283	Sorex araneus	59.03	1.00e-134	472.00
IUUC-Ssc-115878	Sus scrofa	80.85	1.00e-106	378.00
IUUC-Tgu-117026	Taeniopygia guttata	45.58	2.00e-125	442.00
IUUC-Tru-117794	Takifugu rubripes	34.50	3.00e-53	202.00
IUUC-Tni-120550	Tetraodon nigroviridis	27.29	1.00e-65	244.00
IUUC-Tbe-127580	Tupaia belangeri	72.51	1.00e-155	542.00
IUUC-Ttr-128648	Tursiops truncatus	73.85	0.00e+00	650.00
IUUC-Vpa-130254	Vicugna pacos	89.71	1.00e-97	350.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence