iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-094059

Ensembl Protein ID

ENSPSIP00000007945.1

UniProt Accession

K7FIT5; K7FIT5_PELSI

Genbank Protein ID

ENSPSIP00000007945

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGCU01071142

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000007140.1	ENSPSIT00000007987.1	ENSPSIP00000007945.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.80e-26	92.1	1355	1408

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1355 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1408
           58********************************.*****99999*******876 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MERLGRNCVD KKNVQEDEQF LGFGSDEEVK VRSPTRSPTV KSSPRKPRRR PRSSPDGSSA 60
AHSDSSSVCS PLSKSETISM EKMKKKDMKS GEKRRGRPPT LSSVKFKLSQ VKDASDVQKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACAATGCA GCCTTCTTGA GGCTGCTCAT ATTGCTGATG TTTTCCCTTC AACTCTTGTA 60
CCAGTTATGG GAGCATCATT TTGGTAAGCA GCAGTGCTGC ATGTCTTCCT GGCTTGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0006351--P:transcription, DNA-templated
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	5.00e-13	69.70
IUUC-Aml-002274	Ailuropoda melanoleuca	80.40	0.00e+00	4982.00
IUUC-Atr-002455	Amborella trichopoda	47.80	6.00e-39	156.00
IUUC-Apl-003478	Anas platyrhynchos	86.74	0.00e+00	4428.00
IUUC-Aca-005086	Anolis carolinensis	67.79	0.00e+00	3731.00
IUUC-Aly-006448	Arabidopsis lyrata	47.80	2.00e-39	157.00
IUUC-Ath-006690	Arabidopsis thaliana	47.10	3.00e-37	150.00
IUUC-Ame-011195	Astyanax mexicanus	44.12	0.00e+00	823.00
IUUC-Bta-012974	Bos taurus	79.89	0.00e+00	4958.00
IUUC-Bdi-014882	Brachypodium distachyon	33.17	8.00e-26	111.00
IUUC-Bol-016540	Brassica oleracea	47.74	7.00e-38	152.00
IUUC-Bra-017422	Brassica rapa	34.01	2.00e-25	110.00
IUUC-Cel-018354	Caenorhabditis elegans	44.16	3.00e-35	145.00
IUUC-Cja-019226	Callithrix jacchus	79.09	0.00e+00	4973.00
IUUC-Cfa-021049	Canis familiaris	80.65	0.00e+00	4989.00
IUUC-Cpo-021459	Cavia porcellus	79.91	0.00e+00	3561.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.78	2.00e-39	159.00
IUUC-Csa-023434	Chlorocebus sabaeus	79.93	0.00e+00	4582.00
IUUC-Cho-024652	Choloepus hoffmanni	76.59	0.00e+00	3251.00
IUUC-Cin-025724	Ciona intestinalis	55.24	3.00e-96	347.00
IUUC-Csv-026268	Ciona savignyi	37.03	3.00e-132	466.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	2.00e-12	67.80
IUUC-Dre-028180	Danio rerio	68.92	0.00e+00	1138.00
IUUC-Dno-029068	Dasypus novemcinctus	77.43	0.00e+00	4693.00
IUUC-Dor-030550	Dipodomys ordii	75.76	0.00e+00	4294.00
IUUC-Dme-032023	Drosophila melanogaster	46.97	7.00e-90	327.00
IUUC-Ete-032834	Echinops telfairi	70.88	0.00e+00	2198.00
IUUC-Eca-033615	Equus caballus	80.69	0.00e+00	4867.00
IUUC-Eeu-035136	Erinaceus europaeus	75.65	0.00e+00	1042.00
IUUC-Fca-036453	Felis catus	72.49	0.00e+00	1986.00
IUUC-Fal-037256	Ficedula albicollis	85.53	0.00e+00	5485.00
IUUC-Gmo-038641	Gadus morhua	66.46	0.00e+00	1100.00
IUUC-Gga-040828	Gallus gallus	86.52	0.00e+00	5404.00
IUUC-Gac-041452	Gasterosteus aculeatus	71.12	0.00e+00	1160.00
IUUC-Gma-043554	Glycine max	48.70	1.00e-38	154.00
IUUC-Ggo-045124	Gorilla gorilla	76.84	0.00e+00	4624.00
IUUC-Hsa-046143	Homo sapiens	80.05	0.00e+00	4882.00
IUUC-Hvu-047762	Hordeum vulgare	35.11	1.00e-18	87.80
IUUC-Itr-049024	Ictidomys tridecemlineatus	77.48	0.00e+00	4244.00
IUUC-Lch-049704	Latimeria chalumnae	71.88	0.00e+00	2294.00
IUUC-Lpe-051476	Leersia perrieri	30.41	5.00e-22	99.80
IUUC-Loc-052181	Lepisosteus oculatus	78.15	0.00e+00	1286.00
IUUC-Laf-053946	Loxodonta africana	80.52	0.00e+00	4816.00
IUUC-Mcc-055508	Macaca mulatta	79.65	0.00e+00	4868.00
IUUC-Meu-056485	Macropus eugenii	76.58	0.00e+00	2820.00
IUUC-Mtr-058327	Medicago truncatula	41.78	2.00e-39	157.00
IUUC-Mga-059943	Meleagris gallopavo	83.62	0.00e+00	4984.00
IUUC-Mmr-061178	Microcebus murinus	79.16	0.00e+00	4900.00
IUUC-Mdo-063031	Monodelphis domestica	81.73	0.00e+00	3733.00
IUUC-Mmu-063650	Mus musculus	78.10	0.00e+00	3500.00
IUUC-Mac-064935	Musa acuminata	33.50	6.00e-28	119.00
IUUC-Mpu-066495	Mustela putorius furo	81.02	0.00e+00	3372.00
IUUC-Mlu-068045	Myotis lucifugus	75.63	0.00e+00	4183.00
IUUC-Nle-069064	Nomascus leucogenys	80.25	0.00e+00	4949.00
IUUC-Opr-071043	Ochotona princeps	74.78	0.00e+00	3604.00
IUUC-Ont-072556	Oreochromis niloticus	65.43	0.00e+00	1123.00
IUUC-Oan-073324	Ornithorhynchus anatinus	75.99	0.00e+00	2129.00
IUUC-Ocu-074190	Oryctolagus cuniculus	78.35	0.00e+00	4812.00
IUUC-Oba-075647	Oryza barthii	49.04	3.00e-38	154.00
IUUC-Obr-076458	Oryza brachyantha	33.00	1.00e-25	111.00
IUUC-Ogl-077851	Oryza glaberrima	32.49	1.00e-24	108.00
IUUC-Ogu-078706	Oryza glumaepatula	32.18	2.00e-25	111.00
IUUC-Oin-079802	Oryza indica	28.12	7.00e-20	92.00
IUUC-Olo-080577	Oryza longistaminata	47.40	6.00e-36	145.00
IUUC-Ome-081214	Oryza meridionalis	49.04	3.00e-38	154.00
IUUC-Oni-083000	Oryza nivara	49.04	3.00e-38	153.00
IUUC-Opu-083842	Oryza punctata	49.04	3.00e-38	153.00
IUUC-Oru-084361	Oryza rufipogon	49.04	3.00e-38	154.00
IUUC-Osa-085421	Oryza sativa	32.49	2.00e-24	107.00
IUUC-Ola-086609	Oryzias latipes	46.79	0.00e+00	746.00
IUUC-Olu-087718	Ostreococcus lucimarinus	46.32	8.00e-36	146.00
IUUC-Oga-088208	Otolemur garnettii	79.29	0.00e+00	4829.00
IUUC-Oar-090152	Ovis aries	79.89	0.00e+00	4998.00
IUUC-Ptr-091127	Pan troglodytes	80.16	0.00e+00	4865.00
IUUC-Pan-092679	Papio anubis	79.87	0.00e+00	3986.00
IUUC-Pma-094258	Petromyzon marinus	59.53	0.00e+00	676.00
IUUC-Ppa-095221	Physcomitrella patens	33.66	2.00e-27	117.00
IUUC-Pfo-096536	Poecilia formosa	66.87	0.00e+00	1122.00
IUUC-Pab-098262	Pongo abelii	80.38	0.00e+00	4913.00
IUUC-Pop-099585	Populus trichocarpa	31.63	4.00e-25	110.00
IUUC-Pca-100358	Procavia capensis	76.37	0.00e+00	4590.00
IUUC-Ppe-101920	Prunus persica	33.02	6.00e-26	112.00
IUUC-Pva-102522	Pteropus vampyrus	75.05	0.00e+00	3853.00
IUUC-Rno-105200	Rattus norvegicus	77.40	0.00e+00	3430.00
IUUC-Sha-107174	Sarcophilus harrisii	81.76	0.00e+00	5096.00
IUUC-Smo-109164	Selaginella moellendorffii	50.97	2.00e-40	161.00
IUUC-Sit-110552	Setaria italica	31.33	4.00e-26	113.00
IUUC-Sly-111176	Solanum lycopersicum	48.05	3.00e-36	147.00
IUUC-Stu-112529	Solanum tuberosum	48.05	2.00e-38	153.00
IUUC-Sar-113503	Sorex araneus	72.11	0.00e+00	2629.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	4.00e-10	60.10
IUUC-Ssc-115509	Sus scrofa	50.75	0.00e+00	758.00
IUUC-Tgu-117047	Taeniopygia guttata	86.20	0.00e+00	5489.00
IUUC-Tru-118328	Takifugu rubripes	66.27	0.00e+00	1144.00
IUUC-Tsy-118953	Tarsius syrichta	72.49	0.00e+00	2402.00
IUUC-Tni-120837	Tetraodon nigroviridis	67.07	0.00e+00	1137.00
IUUC-Tca-121624	Theobroma cacao	32.99	7.00e-26	112.00
IUUC-Tae-125629	Triticum aestivum	29.72	5.00e-19	89.00
IUUC-Tbe-127950	Tupaia belangeri	80.25	0.00e+00	2264.00
IUUC-Ttr-128643	Tursiops truncatus	78.67	0.00e+00	4780.00
IUUC-Vpa-130660	Vicugna pacos	80.07	0.00e+00	1783.00
IUUC-Vvi-131476	Vitis vinifera	46.47	2.00e-39	158.00
IUUC-Xtr-132869	Xenopus tropicalis	60.04	0.00e+00	3626.00
IUUC-Xma-133393	Xiphophorus maculatus	64.51	0.00e+00	1074.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence