iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053638

UUCD1 version

UUC-LoA-00746

Ensembl Protein ID

ENSLAFP00000020299.1

UniProt Accession

G3TXJ1; G3TXJ1_LOXAF

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000012649.3	ENSLAFT00000028911.1	ENSLAFP00000020299.1
ENSLAFG00000012649.3	ENSLAFT00000012650.3	ENSLAFP00000010577.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-134	447.5	513	842

Active Site

Position(s)	Description	Evidence
812	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld +l
   Q: 513  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFL 601
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv+++r
   Q: 602  IRPFYKMMLQKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWR 685
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l+++F+e+elell+cG +++dv+d++++t+yk++y++ +++iqwFw+++ +++se+r ++LqFvTg
   Q: 686  FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLADVDVNDWREHTRYKNNYSAGHQVIQWFWKAVLMMDSEKRIRLLQFVTG 774
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+Pl+Gfael     p+ f++++++++d+lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 775  TSRVPLNGFAELCgsngPQCFTVEQWGTPDKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 842
           *******************************************************************8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

TRDDFLGQVD VPLYPLPTEN PRMERPYTFK DFVLHPRSHK SRVKGHLRLK MTYLPKTSGS 60
EEDNAEQAEE LEPGWVVLDQ PDAACHLQQQ QEPPPLPPGW EERQDILGRT YYVNHESRRT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAGGGACG ATTTCCTAGG TCAAGTGGAT GTTCCTCTGT ATCCATTACC GGTTAGTATA 60
GATGTCCATG ATTTTAGTTT TTGTGTTTAT TCTTTTTAAT TTGATAAATA CTTTTAAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0003197--P:endocardial cushion development
GO:0010766--P:negative regulation of sodium ion transport
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0003151--P:outflow tract morphogenesis
GO:0045732--P:positive regulation of protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048814--P:regulation of dendrite morphogenesis
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	85.93	0.00e+00	1451.00
IUUC-Apl-003886	Anas platyrhynchos	75.35	0.00e+00	1240.00
IUUC-Ame-011138	Astyanax mexicanus	82.85	0.00e+00	828.00
IUUC-Bta-012453	Bos taurus	84.24	0.00e+00	1345.00
IUUC-Cja-019034	Callithrix jacchus	84.38	0.00e+00	1284.00
IUUC-Cfa-020258	Canis familiaris	85.34	0.00e+00	1376.00
IUUC-Cpo-021648	Cavia porcellus	80.95	0.00e+00	1343.00
IUUC-Csa-023334	Chlorocebus sabaeus	86.41	0.00e+00	1397.00
IUUC-Cin-025157	Ciona intestinalis	54.15	0.00e+00	854.00
IUUC-Dno-029159	Dasypus novemcinctus	81.20	0.00e+00	1241.00
IUUC-Ete-032409	Echinops telfairi	76.20	0.00e+00	1116.00
IUUC-Eca-033441	Equus caballus	86.29	0.00e+00	1359.00
IUUC-Eeu-034546	Erinaceus europaeus	69.39	0.00e+00	1094.00
IUUC-Fca-036384	Felis catus	85.14	0.00e+00	1425.00
IUUC-Hsa-046479	Homo sapiens	86.41	0.00e+00	1439.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	92.15	0.00e+00	915.00
IUUC-Lch-050445	Latimeria chalumnae	67.92	0.00e+00	1130.00
IUUC-Mcc-055585	Macaca mulatta	85.46	0.00e+00	1409.00
IUUC-Meu-056897	Macropus eugenii	93.03	3.00e-165	575.00
IUUC-Mga-059362	Meleagris gallopavo	72.87	0.00e+00	1214.00
IUUC-Mmr-061061	Microcebus murinus	86.75	0.00e+00	1448.00
IUUC-Mpu-066567	Mustela putorius furo	85.75	0.00e+00	1442.00
IUUC-Mlu-068148	Myotis lucifugus	85.70	0.00e+00	1399.00
IUUC-Nle-069225	Nomascus leucogenys	86.76	0.00e+00	1429.00
IUUC-Oan-073019	Ornithorhynchus anatinus	77.71	0.00e+00	1270.00
IUUC-Ocu-074409	Oryctolagus cuniculus	84.75	0.00e+00	1414.00
IUUC-Oga-088241	Otolemur garnettii	79.01	0.00e+00	1243.00
IUUC-Oar-089797	Ovis aries	86.27	0.00e+00	1393.00
IUUC-Ptr-091629	Pan troglodytes	84.89	0.00e+00	1282.00
IUUC-Psi-093618	Pelodiscus sinensis	76.36	0.00e+00	1238.00
IUUC-Pab-098394	Pongo abelii	86.17	0.00e+00	1409.00
IUUC-Pca-100568	Procavia capensis	75.06	0.00e+00	1103.00
IUUC-Tgu-117474	Taeniopygia guttata	74.53	0.00e+00	1223.00
IUUC-Tru-117675	Takifugu rubripes	62.03	0.00e+00	1008.00
IUUC-Tbe-127408	Tupaia belangeri	76.73	0.00e+00	1053.00
IUUC-Ttr-128437	Tursiops truncatus	76.62	0.00e+00	1090.00
IUUC-Vpa-130503	Vicugna pacos	80.88	0.00e+00	1162.00
IUUC-Xtr-132431	Xenopus tropicalis	69.37	0.00e+00	1162.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence