iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-76	258.7	527	853

Active Site

Position(s)	Description	Evidence
823	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l
   Q: 527  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFL 615
           355*****************************9999*99**********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeY 173
            l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      +++++++++f ++ +    l++++++eL+pgG  i V +e+++++
   Q: 616  VLALPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVME-----GVDKETFEFKFGKELTFttvLSDQQVVELIPGGTGIVVEYEDRSRF 699
           **************************************.....556666777777443334449************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  keqv+a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ +++++  +q+Fwe+l++f++e+r+
   Q: 700  IQLVRKARLEE-SKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDTRVQYFWEALNNFTNEDRS 786
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 787  RFLRFVTGRSRLPA--------RIYIYPDklgYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAID 853
           *************5........6667777799999**********************************998776 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus faciliting cell cycle progression by regulating the turn-over of TRIOBP (By imilarity). Mediates also ubiquitination of STX8.

Protein Sequence
(Fasta)

MAGPGPGAAL ESPRQLLGRV RFLAEAARSL RAGLPLPAAL AFVPREVLYK LYKDPAGPSR 60
VLLPVWEAEG LGLRVGAVGA APGTGSGPLR AARDSIELRR GACVRTTGEE LCNGHGLWVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTGTGGTG GGAAGCTCTG CTTGCTGTCC CCTGGCTGCG GCCGGCCAGG GTTTCCCTGG 60
ACGAGTCTCA CTTCAGCGGC TTCGCTATGG CCGGCCCTGG CCCCGGCGCG GCGCTTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0019905--F:syntaxin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

mmu:76608

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	97.21	0.00e+00	1664.00
IUUC-Apl-003715	Anas platyrhynchos	85.39	0.00e+00	1324.00
IUUC-Aca-004377	Anolis carolinensis	78.89	0.00e+00	1391.00
IUUC-Ame-011918	Astyanax mexicanus	64.40	0.00e+00	1122.00
IUUC-Bta-012736	Bos taurus	98.03	0.00e+00	1686.00
IUUC-Cja-019926	Callithrix jacchus	97.44	0.00e+00	1672.00
IUUC-Cfa-020753	Canis familiaris	97.75	0.00e+00	1165.00
IUUC-Cpo-021415	Cavia porcellus	97.56	0.00e+00	1677.00
IUUC-Csa-023096	Chlorocebus sabaeus	97.56	0.00e+00	1667.00
IUUC-Dre-028746	Danio rerio	69.28	0.00e+00	1199.00
IUUC-Dno-029293	Dasypus novemcinctus	98.12	0.00e+00	1073.00
IUUC-Dor-031113	Dipodomys ordii	98.68	0.00e+00	1240.00
IUUC-Ete-032601	Echinops telfairi	89.17	0.00e+00	1417.00
IUUC-Eca-034198	Equus caballus	95.24	0.00e+00	1629.00
IUUC-Eeu-034708	Erinaceus europaeus	96.88	0.00e+00	895.00
IUUC-Fca-035478	Felis catus	97.58	0.00e+00	1644.00
IUUC-Fal-037366	Ficedula albicollis	76.87	0.00e+00	1347.00
IUUC-Gmo-039020	Gadus morhua	75.46	0.00e+00	1047.00
IUUC-Gga-040332	Gallus gallus	79.56	0.00e+00	1409.00
IUUC-Gac-042336	Gasterosteus aculeatus	69.86	0.00e+00	1243.00
IUUC-Ggo-045382	Gorilla gorilla	97.79	0.00e+00	1670.00
IUUC-Hsa-046562	Homo sapiens	97.79	0.00e+00	1670.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	98.26	0.00e+00	1681.00
IUUC-Lch-049606	Latimeria chalumnae	65.73	0.00e+00	842.00
IUUC-Loc-052448	Lepisosteus oculatus	62.75	0.00e+00	1072.00
IUUC-Laf-054507	Loxodonta africana	96.52	0.00e+00	1687.00
IUUC-Mcc-055690	Macaca mulatta	97.56	0.00e+00	1669.00
IUUC-Meu-055970	Macropus eugenii	85.13	0.00e+00	1449.00
IUUC-Mga-059654	Meleagris gallopavo	85.46	0.00e+00	1306.00
IUUC-Mmr-061069	Microcebus murinus	98.37	0.00e+00	1681.00
IUUC-Mdo-062547	Monodelphis domestica	91.96	0.00e+00	792.00
IUUC-Mpu-065846	Mustela putorius furo	97.21	0.00e+00	1676.00
IUUC-Mlu-067992	Myotis lucifugus	97.04	0.00e+00	1571.00
IUUC-Nle-069565	Nomascus leucogenys	97.65	0.00e+00	1564.00
IUUC-Opr-070853	Ochotona princeps	83.97	0.00e+00	1011.00
IUUC-Ont-071628	Oreochromis niloticus	69.24	0.00e+00	1209.00
IUUC-Ocu-074094	Oryctolagus cuniculus	98.03	0.00e+00	1678.00
IUUC-Ola-087384	Oryzias latipes	69.37	0.00e+00	1256.00
IUUC-Oga-088224	Otolemur garnettii	97.43	0.00e+00	1676.00
IUUC-Oar-090043	Ovis aries	91.64	0.00e+00	1566.00
IUUC-Ptr-090852	Pan troglodytes	97.56	0.00e+00	1662.00
IUUC-Pan-092787	Papio anubis	97.56	0.00e+00	1670.00
IUUC-Psi-092986	Pelodiscus sinensis	72.57	0.00e+00	979.00
IUUC-Pma-094416	Petromyzon marinus	40.02	2.00e-175	609.00
IUUC-Pfo-096720	Poecilia formosa	69.44	0.00e+00	1251.00
IUUC-Pab-098325	Pongo abelii	97.47	0.00e+00	1293.00
IUUC-Pca-100885	Procavia capensis	83.15	0.00e+00	1195.00
IUUC-Pva-102829	Pteropus vampyrus	85.89	0.00e+00	1056.00
IUUC-Rno-104882	Rattus norvegicus	99.07	0.00e+00	1689.00
IUUC-Sha-106811	Sarcophilus harrisii	91.51	1.00e-116	412.00
IUUC-Sar-113020	Sorex araneus	82.42	0.00e+00	700.00
IUUC-Ssc-115436	Sus scrofa	97.78	2.00e-158	551.00
IUUC-Tgu-117042	Taeniopygia guttata	79.06	0.00e+00	1396.00
IUUC-Tru-118419	Takifugu rubripes	67.21	0.00e+00	1170.00
IUUC-Tsy-118829	Tarsius syrichta	97.94	0.00e+00	995.00
IUUC-Tni-120410	Tetraodon nigroviridis	56.55	0.00e+00	927.00
IUUC-Tbe-128113	Tupaia belangeri	97.91	0.00e+00	773.00
IUUC-Ttr-128167	Tursiops truncatus	93.38	0.00e+00	1605.00
IUUC-Xtr-132910	Xenopus tropicalis	64.31	0.00e+00	1077.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence