iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000010673.4	ENSCAFT00000045680.2	ENSCAFP00000041811.1
ENSCAFG00000010673.4	ENSCAFT00000016982.3	ENSCAFP00000015710.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-121	406.6	1100	1432

Active Site

Position(s)	Description	Evidence
1400	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1100 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1185
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1186 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1268
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1269 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1355
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1356 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1432
           **************************************************************************985 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MEPEIKICFK YYHGISGALR ATTPCITVKN PAVMMGAEGM EGGASGNQHS RKLVSFTLSD 60
LRAVGLKKGM FFNPDPYLKM SIQPGKKSSF PTCAHHGQER RSTIISNTTN PIWHREKYSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGTAAGTC TTGAGGAAAA GTGGGAGTGG CTCTCAATGT TTTCTTAGCT GGACAGGAGT 60
CTGCTGGTAG AGGTCTGCTC AAATCCTGCT TAGGATTTCA TTTCTAGAAC TTTGGGAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	99.62	0.00e+00	1636.00
IUUC-Apl-003935	Anas platyrhynchos	97.99	0.00e+00	1619.00
IUUC-Aca-004558	Anolis carolinensis	97.47	0.00e+00	1603.00
IUUC-Ame-010893	Astyanax mexicanus	88.75	0.00e+00	1303.00
IUUC-Bta-013093	Bos taurus	96.47	0.00e+00	1575.00
IUUC-Cja-019651	Callithrix jacchus	79.90	0.00e+00	2211.00
IUUC-Cpo-021770	Cavia porcellus	98.23	0.00e+00	1637.00
IUUC-Csa-023970	Chlorocebus sabaeus	99.24	0.00e+00	1633.00
IUUC-Cho-024512	Choloepus hoffmanni	87.67	0.00e+00	1389.00
IUUC-Csv-026127	Ciona savignyi	72.27	9.00e-155	540.00
IUUC-Dre-028275	Danio rerio	89.04	0.00e+00	1461.00
IUUC-Dno-029963	Dasypus novemcinctus	98.48	0.00e+00	1611.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	656.00
IUUC-Ete-033132	Echinops telfairi	83.18	0.00e+00	1259.00
IUUC-Eca-033978	Equus caballus	99.12	0.00e+00	1622.00
IUUC-Fca-036157	Felis catus	99.49	0.00e+00	1623.00
IUUC-Fal-037110	Ficedula albicollis	98.11	0.00e+00	1611.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1013.00
IUUC-Gga-040821	Gallus gallus	98.35	0.00e+00	1617.00
IUUC-Gac-042181	Gasterosteus aculeatus	88.58	0.00e+00	1419.00
IUUC-Ggo-044862	Gorilla gorilla	99.62	0.00e+00	1634.00
IUUC-Hsa-046219	Homo sapiens	99.49	0.00e+00	1664.00
IUUC-Lch-050526	Latimeria chalumnae	92.68	0.00e+00	1526.00
IUUC-Loc-052648	Lepisosteus oculatus	91.68	0.00e+00	1503.00
IUUC-Laf-054005	Loxodonta africana	81.05	0.00e+00	2236.00
IUUC-Mcc-055314	Macaca mulatta	99.49	0.00e+00	1635.00
IUUC-Meu-056356	Macropus eugenii	81.10	0.00e+00	793.00
IUUC-Mga-060074	Meleagris gallopavo	98.15	0.00e+00	1538.00
IUUC-Mmr-061526	Microcebus murinus	99.49	0.00e+00	1633.00
IUUC-Mdo-063017	Monodelphis domestica	98.73	0.00e+00	1579.00
IUUC-Mmu-064165	Mus musculus	99.12	0.00e+00	1628.00
IUUC-Mpu-065835	Mustela putorius furo	95.84	0.00e+00	1548.00
IUUC-Mlu-067709	Myotis lucifugus	97.85	0.00e+00	1592.00
IUUC-Nle-069308	Nomascus leucogenys	99.49	0.00e+00	1635.00
IUUC-Opr-070330	Ochotona princeps	85.48	0.00e+00	1358.00
IUUC-Ont-071345	Oreochromis niloticus	87.91	0.00e+00	1442.00
IUUC-Ocu-074775	Oryctolagus cuniculus	99.75	0.00e+00	1637.00
IUUC-Ola-087225	Oryzias latipes	83.71	0.00e+00	1335.00
IUUC-Oga-088177	Otolemur garnettii	99.24	0.00e+00	1628.00
IUUC-Oar-089452	Ovis aries	99.24	0.00e+00	1629.00
IUUC-Ptr-090806	Pan troglodytes	99.49	0.00e+00	1637.00
IUUC-Pan-091838	Papio anubis	99.37	0.00e+00	1628.00
IUUC-Psi-094090	Pelodiscus sinensis	97.23	0.00e+00	1569.00
IUUC-Pfo-096520	Poecilia formosa	87.89	0.00e+00	1445.00
IUUC-Pab-098405	Pongo abelii	99.62	0.00e+00	1637.00
IUUC-Pva-102324	Pteropus vampyrus	99.12	0.00e+00	1620.00
IUUC-Rno-105943	Rattus norvegicus	98.99	0.00e+00	1628.00
IUUC-Sha-106985	Sarcophilus harrisii	95.56	0.00e+00	1535.00
IUUC-Sar-113505	Sorex araneus	95.58	0.00e+00	1535.00
IUUC-Ssc-115534	Sus scrofa	100.00	0.00e+00	764.00
IUUC-Tgu-117078	Taeniopygia guttata	97.74	0.00e+00	1608.00
IUUC-Tru-118671	Takifugu rubripes	87.77	0.00e+00	1431.00
IUUC-Tni-120619	Tetraodon nigroviridis	87.39	0.00e+00	1419.00
IUUC-Ttr-128469	Tursiops truncatus	88.64	0.00e+00	1396.00
IUUC-Vpa-130498	Vicugna pacos	81.22	0.00e+00	1204.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence