iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000173960.12	ENST00000404924.5	ENSP00000385525.1
ENSG00000173960.12	ENST00000535786.5	ENSP00000440533.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWAS Central
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/UBX	UBX	24625977

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/UBX	1.90e-15	58.8	172	245

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/UBX

   S: 4    eqatlqiRlpdGkrlvrkFpssttleqiyqfve.yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsll 78
           + +++qi+l++Gkr+v+kF+ ++++++i +f+e y+ +++s pF+L +++P   l +e+   tl+ea+L +  +++
   Q: 172  PITNIQIWLANGKRIVQKFNITHRVSHIKDFIEkYQGSQRSPPFSLATALPVLRLLDETL--TLEEADLQNAVIIQ 245
           5689********************************************************..*********99886 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MKDVDNLKSI KEEWVCETGS DNQPLGNNQQ SNCEYFVDSL FEEAQKVSSK CVSPAEQKKQ 60
VDVNIKLWKN GFTVNDDFRS YSDGASQQFL NSIKKGELPS ELQGIFDKEE VDVKVEDKKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTCTCCCC GACCGCAGGG CTGGGGCGAC CAGAAAAGCC AGACTAATCA GGACGAGTTC 60
GGGCGTGGAA TTGGGCCTGA AGCCCTCATG CCCAGCCAGG CCTGAATGCC CCAGACCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR012989--SEP_domain
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS51399--SEP
PS50033--UBX

Pfam

PF08059--SEP
PF00789--UBX

SMART

SM00553--SEP
SM00166--UBX

Gene Ontology

GO:0005801--C:cis-Golgi network
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0043130--F:ubiquitin binding
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0031468--P:nuclear envelope reassembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010468--P:regulation of gene expression
GO:0042176--P:regulation of protein catabolic process
GO:0031396--P:regulation of protein ubiquitination

KEGG

hsa:165324

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002393	Ailuropoda melanoleuca	89.84	2.00e-109	388.00
IUUC-Apl-004089	Anas platyrhynchos	63.18	1.00e-81	296.00
IUUC-Aca-005094	Anolis carolinensis	57.14	4.00e-73	267.00
IUUC-Bta-012790	Bos taurus	90.31	2.00e-117	415.00
IUUC-Cja-019967	Callithrix jacchus	94.23	2.00e-122	431.00
IUUC-Cfa-020180	Canis familiaris	88.76	7.00e-116	409.00
IUUC-Cpo-021719	Cavia porcellus	82.24	1.00e-109	389.00
IUUC-Csa-023840	Chlorocebus sabaeus	96.15	7.00e-128	449.00
IUUC-Cho-024683	Choloepus hoffmanni	88.84	1.00e-114	405.00
IUUC-Dre-028501	Danio rerio	42.29	3.00e-49	188.00
IUUC-Dno-029129	Dasypus novemcinctus	84.88	2.00e-121	427.00
IUUC-Ete-033198	Echinops telfairi	79.19	4.00e-69	254.00
IUUC-Eca-033335	Equus caballus	90.31	3.00e-117	414.00
IUUC-Fca-036141	Felis catus	90.31	8.00e-115	406.00
IUUC-Fal-037574	Ficedula albicollis	65.90	3.00e-81	294.00
IUUC-Gmo-039656	Gadus morhua	38.67	8.00e-37	147.00
IUUC-Gga-040681	Gallus gallus	62.16	3.00e-81	295.00
IUUC-Gac-042408	Gasterosteus aculeatus	42.79	2.00e-42	166.00
IUUC-Ggo-045649	Gorilla gorilla	99.23	3.00e-132	464.00
IUUC-Lch-050482	Latimeria chalumnae	51.75	2.00e-66	245.00
IUUC-Loc-052184	Lepisosteus oculatus	43.72	2.00e-47	182.00
IUUC-Laf-053715	Loxodonta africana	87.94	7.00e-113	399.00
IUUC-Mga-060206	Meleagris gallopavo	62.02	9.00e-81	293.00
IUUC-Mmr-061401	Microcebus murinus	89.62	4.00e-117	413.00
IUUC-Mdo-061891	Monodelphis domestica	59.92	3.00e-84	305.00
IUUC-Mmu-063822	Mus musculus	84.88	2.00e-110	391.00
IUUC-Mpu-066583	Mustela putorius furo	87.45	1.00e-109	388.00
IUUC-Mlu-067179	Myotis lucifugus	85.99	1.00e-106	379.00
IUUC-Nle-069125	Nomascus leucogenys	98.46	3.00e-131	461.00
IUUC-Opr-070527	Ochotona princeps	68.13	3.00e-85	308.00
IUUC-Ont-072648	Oreochromis niloticus	41.25	3.00e-44	171.00
IUUC-Oan-072825	Ornithorhynchus anatinus	70.75	1.00e-79	289.00
IUUC-Ocu-073897	Oryctolagus cuniculus	89.11	1.00e-115	409.00
IUUC-Oga-088217	Otolemur garnettii	87.69	3.00e-114	404.00
IUUC-Oar-090372	Ovis aries	89.15	6.00e-116	409.00
IUUC-Ptr-091011	Pan troglodytes	98.84	3.00e-125	441.00
IUUC-Pan-092177	Papio anubis	96.92	2.00e-128	451.00
IUUC-Psi-093793	Pelodiscus sinensis	63.46	1.00e-81	296.00
IUUC-Pfo-096059	Poecilia formosa	43.46	8.00e-43	166.00
IUUC-Pab-098103	Pongo abelii	94.66	8.00e-121	426.00
IUUC-Pca-101031	Procavia capensis	68.78	6.00e-81	293.00
IUUC-Pva-102671	Pteropus vampyrus	72.83	2.00e-83	301.00
IUUC-Rno-105700	Rattus norvegicus	83.33	5.00e-107	380.00
IUUC-Sha-106530	Sarcophilus harrisii	45.80	1.00e-45	176.00
IUUC-Sar-113329	Sorex araneus	62.79	1.00e-57	216.00
IUUC-Ssc-115898	Sus scrofa	88.52	2.00e-117	415.00
IUUC-Tgu-116984	Taeniopygia guttata	63.57	2.00e-83	301.00
IUUC-Tru-118339	Takifugu rubripes	45.74	2.00e-52	198.00
IUUC-Tbe-127537	Tupaia belangeri	72.65	2.00e-79	288.00
IUUC-Ttr-128822	Tursiops truncatus	72.37	2.00e-91	328.00
IUUC-Vpa-130266	Vicugna pacos	73.75	1.00e-83	302.00
IUUC-Xtr-132381	Xenopus tropicalis	53.12	1.00e-67	249.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence