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Tag Content
UUCD2 ID IUUC-Pab-098127
UUCD1 version UUC-PoA-00644
Ensembl Protein ID ENSPPYP00000016972.2
UniProt Accession Q5RBR0; SH3R1_PONAB
Genbank Protein ID CAH90800.1
Protein Name E3 ubiquitin-protein ligase SH3RF1; Plenty of SH3s; RING-type E3 ubiquitin transferase SH3RF1; SH3 domain-containing RING finger protein 1
Genbank Nucleotide ID CR858578
Gene Name SH3RF1; POSH
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000015189.2 ENSPPYT00000017658.2 ENSPPYP00000016972.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 5.80e-08 33.2 12 53
UBD/SH3 4.80e-48 161.0 449 504
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle+++   +vlpC+H+f++ Cl  +      s++e rCP Cr
   Q: 12   CPVCLERLDASAKVLPCQHTFCKRCLLGI----VGSRNELRCPECR 53
           **********9**************9777....899*********8 PP
   

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +  ++y+y++ ++deL+l+kG++ lv  + +   gW kg++  + k G+fP n+v+ +
   Q: 449  VYVAIYPYTPRKEDELELRKGEMFLVF-ERC-QDGWFKGTSMHTSKIGVFPGNYVAPV 504
           5679**********************9.555.569********************988 PP
   
Organism Pongo abelii
Functional Description
(View)

Functional Description


     Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.
 Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes such as UBE2D1 or UBE2N and then transfers it to substrates. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis.
Protein Sequence
(Fasta)
MDESALLDLL ECPVCLERLD ASAKVLPCQH TFCKRCLLGI VGSRNELRCP ECRTLVGSGV 60
EELPSNILLV RLLDGIKQRP WKPGPGGGSG TNCTNALRSQ SSTVANCSSK DLQSSQGGQQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-098127|E3,RING;UBD,SH3|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTCCCCTCG TAGTCCCCTG GGGGCCCCGC TCCCCATCCT CTAGGCTCTT GCAGCGCCCC 60
CTCAGGCCGC CGCCCCAATC CCGCCCCCGG GCTCCGGCGG GGTACTGGGC GCAGGTCACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-098127|E3,RING;UBD,SH3|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001452--SH3_domain
IPR028502--SH3RF1
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00018--SH3_1
PF14604--SH3_9
PF00097--zf-C3HC4
PRINTS

PR00452--SH3DOMAIN
SMART

SM00184--RING
SM00326--SH3
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0030027--C:lamellipodium
GO:0048471--C:perinuclear region of cytoplasm
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0016567--P:protein ubiquitination
GO:0046328--P:regulation of JNK cascade
KEGG pon:100172363
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001528 Ailuropoda melanoleuca 91.13 0.00e+00 1350.00
IUUC-Apl-003961 Anas platyrhynchos 80.41 0.00e+00 1196.00
IUUC-Aca-004386 Anolis carolinensis 76.54 0.00e+00 1179.00
IUUC-Ame-010659 Astyanax mexicanus 72.99 1.00e-148 520.00
IUUC-Bta-012563 Bos taurus 65.86 2.00e-128 452.00
IUUC-Cja-019730 Callithrix jacchus 94.72 0.00e+00 1369.00
IUUC-Cfa-020992 Canis familiaris 91.36 0.00e+00 1387.00
IUUC-Cpo-021304 Cavia porcellus 92.35 0.00e+00 1454.00
IUUC-Csa-023925 Chlorocebus sabaeus 98.65 0.00e+00 1412.00
IUUC-Cho-024630 Choloepus hoffmanni 84.36 0.00e+00 889.00
IUUC-Cin-025274 Ciona intestinalis 48.71 4.00e-71 261.00
IUUC-Csv-026136 Ciona savignyi 41.13 3.00e-71 261.00
IUUC-Dre-028290 Danio rerio 61.35 0.00e+00 894.00
IUUC-Dno-029083 Dasypus novemcinctus 88.19 0.00e+00 1281.00
IUUC-Dor-030388 Dipodomys ordii 94.94 0.00e+00 677.00
IUUC-Dme-032207 Drosophila melanogaster 42.25 1.00e-63 238.00
IUUC-Ete-032809 Echinops telfairi 79.37 0.00e+00 839.00
IUUC-Eca-034185 Equus caballus 92.49 0.00e+00 1115.00
IUUC-Eeu-034816 Erinaceus europaeus 77.83 0.00e+00 1152.00
IUUC-Fca-036439 Felis catus 90.16 0.00e+00 1409.00
IUUC-Fal-037074 Ficedula albicollis 79.05 0.00e+00 1171.00
IUUC-Gmo-039443 Gadus morhua 69.11 9.00e-93 334.00
IUUC-Ggr-040119 Gaeumannomyces graminis 40.68 1.00e-11 65.90
IUUC-Gga-040749 Gallus gallus 78.60 0.00e+00 1136.00
IUUC-Gac-041420 Gasterosteus aculeatus 73.84 5.00e-148 518.00
IUUC-Ggo-045215 Gorilla gorilla 98.65 0.00e+00 1482.00
IUUC-Hsa-046315 Homo sapiens 99.21 0.00e+00 1481.00
IUUC-Itr-048265 Ictidomys tridecemlineatus 91.02 2.00e-158 551.00
IUUC-Lch-049453 Latimeria chalumnae 69.86 0.00e+00 895.00
IUUC-Loc-052248 Lepisosteus oculatus 39.43 1.00e-76 281.00
IUUC-Laf-053651 Loxodonta africana 90.67 0.00e+00 1320.00
IUUC-Mcc-054688 Macaca mulatta 97.87 0.00e+00 1449.00
IUUC-Meu-056291 Macropus eugenii 74.96 0.00e+00 781.00
IUUC-Mga-059944 Meleagris gallopavo 77.70 0.00e+00 1159.00
IUUC-Mmr-061553 Microcebus murinus 91.55 0.00e+00 1268.00
IUUC-Mdo-062313 Monodelphis domestica 77.54 0.00e+00 1182.00
IUUC-Mmu-063516 Mus musculus 90.27 0.00e+00 1392.00
IUUC-Mpu-066064 Mustela putorius furo 91.33 0.00e+00 1366.00
IUUC-Mlu-067312 Myotis lucifugus 89.52 0.00e+00 1296.00
IUUC-Nle-069035 Nomascus leucogenys 98.20 0.00e+00 1477.00
IUUC-Opr-070690 Ochotona princeps 86.54 0.00e+00 671.00
IUUC-Ont-071484 Oreochromis niloticus 58.41 0.00e+00 860.00
IUUC-Oan-073305 Ornithorhynchus anatinus 82.45 0.00e+00 1228.00
IUUC-Ocu-074936 Oryctolagus cuniculus 90.85 0.00e+00 1386.00
IUUC-Ola-086675 Oryzias latipes 60.59 3.00e-175 608.00
IUUC-Oga-087933 Otolemur garnettii 82.68 0.00e+00 1026.00
IUUC-Oar-090408 Ovis aries 69.78 0.00e+00 741.00
IUUC-Ptr-090865 Pan troglodytes 99.44 0.00e+00 1484.00
IUUC-Pan-092362 Papio anubis 98.76 0.00e+00 1410.00
IUUC-Psi-093876 Pelodiscus sinensis 79.30 0.00e+00 1207.00
IUUC-Pfo-097116 Poecilia formosa 59.18 0.00e+00 843.00
IUUC-Pca-100485 Procavia capensis 89.07 0.00e+00 1014.00
IUUC-Pva-102661 Pteropus vampyrus 89.53 0.00e+00 1287.00
IUUC-Rno-105728 Rattus norvegicus 88.85 0.00e+00 1373.00
IUUC-Sha-106515 Sarcophilus harrisii 85.83 0.00e+00 863.00
IUUC-Sar-113161 Sorex araneus 96.07 0.00e+00 671.00
IUUC-Ssc-115314 Sus scrofa 77.59 0.00e+00 1091.00
IUUC-Tgu-117012 Taeniopygia guttata 79.62 0.00e+00 1176.00
IUUC-Tru-118467 Takifugu rubripes 61.20 9.00e-160 557.00
IUUC-Tsy-119566 Tarsius syrichta 83.99 1.00e-175 610.00
IUUC-Tni-120830 Tetraodon nigroviridis 59.14 2.00e-167 582.00
IUUC-Tbe-128070 Tupaia belangeri 88.11 0.00e+00 916.00
IUUC-Ttr-128161 Tursiops truncatus 94.51 4.00e-143 502.00
IUUC-Xtr-132628 Xenopus tropicalis 72.45 0.00e+00 1081.00
IUUC-Xma-133732 Xiphophorus maculatus 59.03 0.00e+00 852.00
Created Date 25-Jun-2017

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