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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046304
UUCD1 version UUC-HoS-00241
Ensembl Protein ID ENSP00000363711.1
UniProt Accession Q8NG27; A2A322; Q5JUT8; Q5JUT9; Q8NG28; Q9HAC1; PJA1_HUMAN
Genbank Protein ID AAM53039.1; AAM53040.1; CAI41604.1; CAI41605.1; EAX05367.1; AAH48323.1; AAH75803.1; AAI05052.1; AAI05054.1; BAB13928.1
Protein Name E3 ubiquitin-protein ligase Praja-1; RING finger protein 70; RING-type E3 ubiquitin transferase Praja-1
Genbank Nucleotide ID AF262024; AF264620; AL157699; AL157699; CH471132; BC048323; BC075803; BC105051; BC105053; AK021892
Gene Name PJA1; RNF70
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000181191.11 ENST00000471141.1 ENSP00000467564.1
ENSG00000181191.11 ENST00000374583.1 ENSP00000363711.1
ENSG00000181191.11 ENST00000374584.3 ENSP00000363712.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPMSZDB
DNA & RNA Element
UTRdbCircNetmicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 11959851; 12036302; 18786927
Classification
Family E-value Score Start End
E3 activity/RING/RING 8.80e-06 27.8 595 636
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++ +g     lpC H fh+ C+  w       +k+ +CP+Cr
   Q: 595  CPICCSEYVKGevATELPCHHYFHKPCVSIW------LQKSGTCPVCR 636
           ********4443233499*************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.
 Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.
Protein Sequence
(Fasta)
MGQESSKPVW PNPTGGYQSN TGRRYGRRHA YVSFRPPTSQ RERIASQRKT NSEVPMHRSA 60
PSQTTKRSRS PFSTTRRSWD DSESSGTNLN IDNEDYSRYP PREYRASGSR RGMAYGHIDS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046304|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGATGTGAT GTAGTAACGT AATTACTCTC ACATTGGACT TAATCAGAAA GAATTTGCAG 60
ATTTTATTTT ATTTATTAAA AAACCAGAAG GCAATATAGC TAAATGTTTA ACATTAGTTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046304|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR031227--PJA1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030163--P:protein catabolic process
KEGG hsa:64219
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002058 Ailuropoda melanoleuca 85.14 0.00e+00 935.00
IUUC-Apl-003808 Anas platyrhynchos 67.21 9.00e-59 219.00
IUUC-Bdi-014634 Brachypodium distachyon 33.08 2.00e-14 72.40
IUUC-Cja-019832 Callithrix jacchus 90.75 6.00e-119 421.00
IUUC-Cfa-020124 Canis familiaris 83.84 6.00e-150 523.00
IUUC-Csa-023998 Chlorocebus sabaeus 95.81 0.00e+00 1051.00
IUUC-Cho-024393 Choloepus hoffmanni 76.29 1.00e-142 499.00
IUUC-Dno-029806 Dasypus novemcinctus 82.24 0.00e+00 763.00
IUUC-Ete-032338 Echinops telfairi 77.76 0.00e+00 681.00
IUUC-Eca-034421 Equus caballus 84.81 7.00e-145 506.00
IUUC-Fca-035465 Felis catus 84.01 0.00e+00 924.00
IUUC-Gma-042873 Glycine max 35.48 6.00e-18 84.00
IUUC-Ggo-044735 Gorilla gorilla 99.53 0.00e+00 1098.00
IUUC-Itr-048973 Ictidomys tridecemlineatus 85.67 0.00e+00 1001.00
IUUC-Laf-054182 Loxodonta africana 78.05 0.00e+00 712.00
IUUC-Mcc-055292 Macaca mulatta 96.94 0.00e+00 940.00
IUUC-Mga-059909 Meleagris gallopavo 68.37 2.00e-23 100.00
IUUC-Mmr-061024 Microcebus murinus 88.99 0.00e+00 952.00
IUUC-Mmu-063776 Mus musculus 73.56 0.00e+00 707.00
IUUC-Mpu-066644 Mustela putorius furo 85.58 0.00e+00 981.00
IUUC-Mlu-067639 Myotis lucifugus 78.14 0.00e+00 885.00
IUUC-Ocu-073783 Oryctolagus cuniculus 81.39 1.00e-146 512.00
IUUC-Oga-088286 Otolemur garnettii 87.29 0.00e+00 986.00
IUUC-Oar-089497 Ovis aries 83.72 0.00e+00 924.00
IUUC-Pan-092534 Papio anubis 94.06 0.00e+00 931.00
IUUC-Pca-100336 Procavia capensis 72.22 4.00e-157 548.00
IUUC-Rno-105580 Rattus norvegicus 78.21 3.00e-115 408.00
IUUC-Ssc-116194 Sus scrofa 85.27 0.00e+00 957.00
IUUC-Tsy-118954 Tarsius syrichta 74.53 3.00e-136 479.00
Created Date 25-Jun-2017

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