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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063776
UUCD1 version UUC-MuM-00273
Ensembl Protein ID ENSMUSP00000109423.1
UniProt Accession O55176; Q8CFU2; Q99MJ1; Q99MJ2; Q99MJ3; Q9DB04; PJA1_MOUSE
Genbank Protein ID AAC00205.2; AAK15764.2; AAK15765.2; AAK15766.1; BAB23982.1; AAH37616.1
Protein Name E3 ubiquitin-protein ligase Praja-1; RING-type E3 ubiquitin transferase Praja-1
Genbank Nucleotide ID U06944; AF335250; AF335251; AF335252; AK005373; BC037616
Gene Name Pja1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034403.16 ENSMUST00000113792.1 ENSMUSP00000109423.1
ENSMUSG00000034403.16 ENSMUST00000113797.3 ENSMUSP00000109428.3
ENSMUSG00000034403.16 ENSMUST00000113790.7 ENSMUSP00000109421.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDPINAHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 5.00e-06 28.1 530 571
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++ +g     lpC H fh+ C+  w       +k+ +CP+Cr
   Q: 530  CPICCSEYVKGevATELPCHHYFHKPCVSIW------LQKSGTCPVCR 571
           ********4443233499*************......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting.
 Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting.
Protein Sequence
(Fasta)
MSHQERIASQ RRTTAEVPMH RSTANQSKRS RSPFASTRRR WDDSESSGAS LAVESEDYSR 60
YPPREYRASG SRRGLAYGHI DTVVARDSEE EGAGPVDRLP VRGKAGKFKD DPEKGARSSR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063776|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTGAACCT GTGCTGCCTG TAATGAACGA TCATCTCTTG CATAGACAAG CCTGGTTTTG 60
TGAGGAACAG CACCAGATTT CACTGTAAAC ACCTTCTGTT TGCCTCAAAC ACCAGGTTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063776|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR031227--PJA1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030163--P:protein catabolic process
KEGG mmu:18744
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002058 Ailuropoda melanoleuca 73.31 0.00e+00 738.00
IUUC-Apl-003808 Anas platyrhynchos 67.21 7.00e-60 223.00
IUUC-Aly-006436 Arabidopsis lyrata 45.21 2.00e-15 75.50
IUUC-Bdi-014634 Brachypodium distachyon 33.08 8.00e-15 73.60
IUUC-Bra-017306 Brassica rapa 45.21 1.00e-15 76.30
IUUC-Cja-019832 Callithrix jacchus 85.00 4.00e-109 388.00
IUUC-Cfa-020124 Canis familiaris 76.92 8.00e-131 459.00
IUUC-Csa-023998 Chlorocebus sabaeus 75.37 0.00e+00 746.00
IUUC-Cho-024393 Choloepus hoffmanni 62.15 5.00e-103 367.00
IUUC-Dno-029806 Dasypus novemcinctus 70.97 4.00e-162 564.00
IUUC-Ete-032338 Echinops telfairi 69.32 4.00e-169 587.00
IUUC-Eca-034421 Equus caballus 76.14 9.00e-132 462.00
IUUC-Fca-035465 Felis catus 75.17 0.00e+00 725.00
IUUC-Gma-042873 Glycine max 35.48 5.00e-18 84.30
IUUC-Ggo-044735 Gorilla gorilla 75.70 0.00e+00 759.00
IUUC-Hsa-046304 Homo sapiens 75.21 0.00e+00 756.00
IUUC-Itr-048973 Ictidomys tridecemlineatus 75.37 0.00e+00 772.00
IUUC-Laf-054182 Loxodonta africana 68.95 2.00e-172 598.00
IUUC-Mcc-055292 Macaca mulatta 75.51 0.00e+00 724.00
IUUC-Mmr-061024 Microcebus murinus 75.21 0.00e+00 720.00
IUUC-Mpu-066644 Mustela putorius furo 73.44 0.00e+00 758.00
IUUC-Mlu-067639 Myotis lucifugus 70.15 0.00e+00 710.00
IUUC-Ocu-073783 Oryctolagus cuniculus 78.55 1.00e-133 469.00
IUUC-Oga-088286 Otolemur garnettii 73.73 0.00e+00 762.00
IUUC-Oar-089497 Ovis aries 75.38 0.00e+00 753.00
IUUC-Pan-092534 Papio anubis 75.74 0.00e+00 717.00
IUUC-Rno-105580 Rattus norvegicus 91.93 1.00e-123 436.00
IUUC-Sbi-114059 Sorghum bicolor 43.42 4.00e-14 71.20
IUUC-Ssc-116194 Sus scrofa 74.79 0.00e+00 755.00
IUUC-Tsy-118954 Tarsius syrichta 67.70 3.00e-122 432.00
Created Date 25-Jun-2017

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