iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045828

UUCD1 version

UUC-HoS-00121

Ensembl Protein ID

ENSP00000323889.4

UniProt Accession

Q14258; TRI25_HUMAN

Genbank Protein ID

BAA04747.1; AAH16924.1; AAH42541.1

Protein Name

E3 ubiquitin/ISG15 ligase TRIM25; Estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147

Genbank Nucleotide ID

D21205; AC015912; BC042541

Gene Name

TRIM25; EFP; RNF147; ZNF147

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000121060.15	ENST00000316881.8	ENSP00000323889.4
ENSG00000121060.15	ENST00000572021.5	ENSP00000459980.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	TRANSFAC	miRWalk	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16352599; 20818395; 17418098; 20406818; 21292167; 24768535

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	7.60e-05	24.4	8	79
E3 activity/RING/RING	2.90e-08	35.8	13	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssI.ekwlasggk.tcPvtrqpl.teedlvPnltlrrliqawcee 71
            ee+ C+I le++++Pv++p+G+ +  s++ e w  +g    cP +r+   +  +l  n++l +++++++++
   Q: 8    AEELSCSICLEPFKEPVTTPCGHNFCGSCLnETWAVQGSPyLCPQCRAVYqARPQLHKNTVLCNVVEQFLQA 79
           5899*********************9999934576666559********944556799******99999986 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle+fk+ p+++pCgH f+ +Cl + w     ++    +CP Cr
   Q: 13   CSICLEPFKE-PVTTPCGHNFCGSCLnETW----AVQGSPYLCPQCR 54
           ********99.****************9**....8899999*****8 PP

Organism

Homo sapiens

Functional Description
(View)

Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).

Protein Sequence
(Fasta)

MAELCPLAEE LSCSICLEPF KEPVTTPCGH NFCGSCLNET WAVQGSPYLC PQCRAVYQAR 60
PQLHKNTVLC NVVEQFLQAD LAREPPADVW TPPARASAPS PNAQVACDHC LKEAAVKTCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCCTCGGA GCGCGGGTGC AGCAGTTGTG TCCCGACCCC TGGGAGCGCC ATGGCAGAGC 60
TGTGCCCCCT GGCCGAGGAG CTGTCGTGCT CCATCTGCCT GGAGCCCTTC AAGGAGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0051--Antiviral defense
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0045296--F:cadherin binding
GO:0016874--F:ligase activity
GO:0003723--F:RNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051607--P:defense response to virus
GO:0036503--P:ERAD pathway
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0016579--P:protein deubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0046596--P:regulation of viral entry into host cell
GO:1902186--P:regulation of viral release from host cell
GO:0043627--P:response to estrogen
GO:0033280--P:response to vitamin D
GO:0019985--P:translesion synthesis

KEGG

hsa:7706

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002424	Ailuropoda melanoleuca	76.74	0.00e+00	975.00
IUUC-Apl-004101	Anas platyrhynchos	47.20	9.00e-166	577.00
IUUC-Aca-005025	Anolis carolinensis	49.06	2.00e-173	602.00
IUUC-Bta-012735	Bos taurus	74.65	0.00e+00	952.00
IUUC-Cja-019996	Callithrix jacchus	83.30	0.00e+00	728.00
IUUC-Cfa-020466	Canis familiaris	75.04	0.00e+00	971.00
IUUC-Cpo-021737	Cavia porcellus	70.62	0.00e+00	874.00
IUUC-Csa-023217	Chlorocebus sabaeus	94.29	0.00e+00	1169.00
IUUC-Cho-024346	Choloepus hoffmanni	50.84	3.00e-70	258.00
IUUC-Dno-030082	Dasypus novemcinctus	75.63	0.00e+00	952.00
IUUC-Dor-030335	Dipodomys ordii	53.23	1.00e-129	456.00
IUUC-Ete-032923	Echinops telfairi	68.54	0.00e+00	786.00
IUUC-Eca-033411	Equus caballus	75.08	0.00e+00	947.00
IUUC-Eeu-034656	Erinaceus europaeus	72.85	9.00e-161	560.00
IUUC-Fca-035371	Felis catus	77.52	0.00e+00	980.00
IUUC-Fal-037008	Ficedula albicollis	45.05	6.00e-157	547.00
IUUC-Gmo-038668	Gadus morhua	34.08	6.00e-104	371.00
IUUC-Gga-040608	Gallus gallus	47.59	4.00e-161	561.00
IUUC-Gac-041409	Gasterosteus aculeatus	51.65	3.00e-57	216.00
IUUC-Ggo-044518	Gorilla gorilla	97.78	0.00e+00	1164.00
IUUC-Itr-049070	Ictidomys tridecemlineatus	65.40	0.00e+00	815.00
IUUC-Lch-050478	Latimeria chalumnae	38.16	4.00e-127	448.00
IUUC-Loc-052864	Lepisosteus oculatus	36.58	2.00e-110	393.00
IUUC-Laf-054325	Loxodonta africana	77.45	4.00e-170	590.00
IUUC-Mcc-054920	Macaca mulatta	94.92	0.00e+00	1174.00
IUUC-Meu-056367	Macropus eugenii	72.83	3.00e-74	273.00
IUUC-Mga-059975	Meleagris gallopavo	49.52	5.00e-162	564.00
IUUC-Mmr-060748	Microcebus murinus	81.49	0.00e+00	1004.00
IUUC-Mdo-062904	Monodelphis domestica	57.63	0.00e+00	697.00
IUUC-Mmu-063891	Mus musculus	73.07	0.00e+00	942.00
IUUC-Mpu-066473	Mustela putorius furo	76.86	0.00e+00	991.00
IUUC-Mlu-068185	Myotis lucifugus	78.01	0.00e+00	963.00
IUUC-Nle-070177	Nomascus leucogenys	96.51	0.00e+00	1190.00
IUUC-Opr-070558	Ochotona princeps	61.54	5.00e-151	527.00
IUUC-Ont-071368	Oreochromis niloticus	47.80	1.00e-52	201.00
IUUC-Ocu-074461	Oryctolagus cuniculus	68.83	2.00e-154	539.00
IUUC-Ola-087394	Oryzias latipes	29.43	1.00e-62	234.00
IUUC-Oga-088937	Otolemur garnettii	75.04	0.00e+00	948.00
IUUC-Oar-089781	Ovis aries	74.89	0.00e+00	642.00
IUUC-Ptr-090771	Pan troglodytes	98.73	0.00e+00	1186.00
IUUC-Pan-092830	Papio anubis	94.44	0.00e+00	1169.00
IUUC-Psi-093664	Pelodiscus sinensis	52.31	6.00e-180	624.00
IUUC-Pma-094147	Petromyzon marinus	27.72	6.00e-62	232.00
IUUC-Pfo-096397	Poecilia formosa	28.32	4.00e-54	206.00
IUUC-Pab-097588	Pongo abelii	96.03	0.00e+00	1169.00
IUUC-Pca-100890	Procavia capensis	74.68	0.00e+00	890.00
IUUC-Pva-102314	Pteropus vampyrus	81.20	0.00e+00	968.00
IUUC-Pgr-103377	Puccinia graminis	37.50	6.00e-06	45.80
IUUC-Rno-105234	Rattus norvegicus	69.69	0.00e+00	908.00
IUUC-Sce-106362	Saccharomyces cerevisiae	44.93	7.00e-09	55.10
IUUC-Sha-106807	Sarcophilus harrisii	53.72	0.00e+00	658.00
IUUC-Sar-113283	Sorex araneus	59.69	8.00e-140	490.00
IUUC-Sbi-113834	Sorghum bicolor	41.05	1.00e-11	63.90
IUUC-Ssc-115878	Sus scrofa	81.70	2.00e-108	385.00
IUUC-Tgu-117026	Taeniopygia guttata	45.19	4.00e-128	451.00
IUUC-Tru-117794	Takifugu rubripes	36.19	5.00e-55	209.00
IUUC-Tni-120550	Tetraodon nigroviridis	27.37	1.00e-66	247.00
IUUC-Tbe-127580	Tupaia belangeri	72.51	1.00e-155	542.00
IUUC-Ttr-128648	Tursiops truncatus	74.90	0.00e+00	657.00
IUUC-Vpa-130254	Vicugna pacos	89.71	1.00e-97	350.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence