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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045905
Ensembl Protein ID ENSP00000306866.5
UniProt Accession O95166; GBRAP_HUMAN
Genbank Protein ID AAD47641.1; BAB21549.1; AAD02337.1; AAD32455.1; AAG09694.1
Protein Name Gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46
Genbank Nucleotide ID AF161586; AB030711; AF044671; AF067171; AF183425
Gene Name GABARAP; FLC3B; HT004
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000170296.9 ENST00000302386.9 ENSP00000306866.5
ENSG00000170296.9 ENST00000570856.1 ENSP00000460489.1
ENSG00000170296.9 ENST00000573928.1 ENSP00000458476.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UBL/ATG8 ATG8 11779480; 23721406
Classification
Family E-value Score Start End
ULD/UBL/ATG8 5.70e-53 179.1 13 116
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/ATG8
   S: 1    krkeevekirdkfpdkiPvivekakkekipeldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnnslvsvsatlaeiyeeekdedgf 92
           kr++e+ekir+k+pd++Pviveka+k++i++ldkkkylvPsdltvgq++++irkr++lraedalf++vnn+++++sat++++y+e+++ed+f
   Q: 13   KRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFF 104
           699***************************************************************************************** PP
   S: 93   lyvayaseetfG 104
           ly+ay++e+++G
   Q: 105  LYIAYSDESVYG 116
           ***********9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
 Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Protein Sequence
(Fasta)
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 60
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL 117
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045905|ULD,ATG8|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTGTTAACG AAAGGAACTT GGAGAACCAA GTCTCGTATG ATGATTACCA TCTTTTACTC 60
CTCTTCAGCC CCAGCTTCCT TGAGGGGACG GTTGGGGAAT AGGTTTAGAG TAATTTTCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045905|ULD,ATG8|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0333--Golgi apparatus
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom
Pfam

PF02991--Atg8
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0044297--C:cell body
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0000139--C:Golgi membrane
GO:0005764--C:lysosome
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005790--C:smooth endoplasmic reticulum
GO:0097225--C:sperm midpiece
GO:0048487--F:beta-tubulin binding
GO:0050811--F:GABA receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0097352--P:autophagosome maturation
GO:0007268--P:chemical synaptic transmission
GO:0008625--P:extrinsic apoptotic signaling pathway via death domain receptors
GO:0016236--P:macroautophagy
GO:0061024--P:membrane organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0006605--P:protein targeting
KEGG hsa:11337
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001323 Ailuropoda melanoleuca 100.00 4.00e-65 239.00
IUUC-Ago-007898 Ashbya gossypii 54.46 3.00e-34 136.00
IUUC-Acl-008314 Aspergillus clavatus 59.48 7.00e-39 152.00
IUUC-Afl-008708 Aspergillus flavus 59.48 9.00e-39 151.00
IUUC-Afu-009097 Aspergillus fumigatus 59.48 7.00e-39 152.00
IUUC-Ang-009530 Aspergillus niger 59.48 7.00e-39 152.00
IUUC-Aor-009909 Aspergillus oryzae 59.48 9.00e-39 151.00
IUUC-Ate-010358 Aspergillus terreus 59.48 7.00e-39 152.00
IUUC-Ame-010914 Astyanax mexicanus 98.28 6.00e-63 231.00
IUUC-Bgr-012248 Blumeria graminis 59.48 1.00e-38 151.00
IUUC-Bta-012805 Bos taurus 100.00 4.00e-65 239.00
IUUC-Bci-013959 Botrytis cinerea 60.34 3.00e-39 153.00
IUUC-Bra-016921 Brassica rapa 58.41 4.00e-39 152.00
IUUC-Cel-018200 Caenorhabditis elegans 83.62 1.00e-54 204.00
IUUC-Cja-019369 Callithrix jacchus 100.00 4.00e-65 239.00
IUUC-Cfa-020603 Canis familiaris 100.00 4.00e-65 239.00
IUUC-Csa-024117 Chlorocebus sabaeus 100.00 4.00e-65 239.00
IUUC-Cin-025297 Ciona intestinalis 92.24 2.00e-59 220.00
IUUC-Cgl-026691 Colletotrichum gloeosporioides 43.12 4.00e-32 130.00
IUUC-Cne-026889 Cryptococcus neoformans 58.04 3.00e-37 147.00
IUUC-Dre-028351 Danio rerio 99.14 1.00e-64 238.00
IUUC-Dno-029218 Dasypus novemcinctus 99.11 1.00e-61 230.00
IUUC-Dor-030245 Dipodomys ordii 100.00 4.00e-65 239.00
IUUC-Dse-031428 Dothistroma septosporum 59.48 7.00e-39 152.00
IUUC-Dme-031813 Drosophila melanogaster 91.45 2.00e-60 223.00
IUUC-Ete-032671 Echinops telfairi 98.29 2.00e-64 236.00
IUUC-Eeu-035131 Erinaceus europaeus 96.55 2.00e-45 172.00
IUUC-Fca-036493 Felis catus 100.00 6.00e-65 239.00
IUUC-Fox-037846 Fusarium oxysporum 59.48 8.00e-39 151.00
IUUC-Fso-038134 Fusarium solani 59.48 9.00e-39 151.00
IUUC-Gmo-039671 Gadus morhua 98.28 7.00e-63 232.00
IUUC-Gga-040257 Gallus gallus 96.55 1.00e-62 231.00
IUUC-Gac-042507 Gasterosteus aculeatus 98.28 3.00e-63 233.00
IUUC-Ggo-044860 Gorilla gorilla 100.00 6.00e-65 238.00
IUUC-Itr-048405 Ictidomys tridecemlineatus 100.00 4.00e-65 239.00
IUUC-Lch-049798 Latimeria chalumnae 77.59 1.00e-51 194.00
IUUC-Loc-052290 Lepisosteus oculatus 98.28 6.00e-63 232.00
IUUC-Laf-054203 Loxodonta africana 100.00 4.00e-65 239.00
IUUC-Mcc-055307 Macaca mulatta 100.00 4.00e-65 239.00
IUUC-Mla-059098 Melampsora laricipopulina 60.34 2.00e-39 154.00
IUUC-Mvi-060496 Microbotryum violaceum 59.82 7.00e-38 149.00
IUUC-Mmr-061776 Microcebus murinus 100.00 4.00e-65 239.00
IUUC-Mmu-064157 Mus musculus 100.00 4.00e-65 239.00
IUUC-Mpu-066028 Mustela putorius furo 100.00 4.00e-65 239.00
IUUC-Mlu-067166 Myotis lucifugus 100.00 4.00e-65 239.00
IUUC-Nfi-068367 Neosartorya fischeri 59.48 7.00e-39 152.00
IUUC-Ncr-068894 Neurospora crassa 59.48 8.00e-39 151.00
IUUC-Nle-069220 Nomascus leucogenys 100.00 4.00e-65 239.00
IUUC-Opr-070777 Ochotona princeps 100.00 5.00e-65 238.00
IUUC-Ocu-074148 Oryctolagus cuniculus 100.00 4.00e-65 239.00
IUUC-Ola-086391 Oryzias latipes 86.84 9.00e-52 194.00
IUUC-Olu-087892 Ostreococcus lucimarinus 63.48 3.00e-40 156.00
IUUC-Oga-088312 Otolemur garnettii 100.00 4.00e-65 239.00
IUUC-Oar-089989 Ovis aries 100.00 4.00e-65 239.00
IUUC-Ptr-091108 Pan troglodytes 100.00 4.00e-65 239.00
IUUC-Pno-095035 Phaeosphaeria nodorum 59.48 1.00e-38 151.00
IUUC-Ppa-095787 Physcomitrella patens 62.07 6.00e-40 155.00
IUUC-Pab-097660 Pongo abelii 100.00 4.00e-65 239.00
IUUC-Pca-100230 Procavia capensis 100.00 4.00e-65 239.00
IUUC-Pte-104230 Pyrenophora teres 59.48 1.00e-38 151.00
IUUC-Rno-105497 Rattus norvegicus 100.00 4.00e-65 239.00
IUUC-Sha-106656 Sarcophilus harrisii 100.00 4.00e-65 239.00
IUUC-Ssl-108578 Sclerotinia sclerotiorum 60.34 2.00e-39 153.00
IUUC-Sit-110531 Setaria italica 61.06 3.00e-39 153.00
IUUC-Sar-113670 Sorex araneus 92.31 9.00e-60 221.00
IUUC-Ssc-116182 Sus scrofa 100.00 4.00e-65 239.00
IUUC-Tru-118632 Takifugu rubripes 98.28 2.00e-63 234.00
IUUC-Tre-122077 Trichoderma reesei 59.48 6.00e-39 152.00
IUUC-Tvi-122400 Trichoderma virens 59.48 6.00e-39 152.00
IUUC-Vda-129807 Verticillium dahliae 59.48 7.00e-39 152.00
IUUC-Xma-133400 Xiphophorus maculatus 98.28 3.00e-63 233.00
Created Date 25-Jun-2017

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