iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090783

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AACZ03112256

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000008891.6	ENSPTRT00000016391.6	ENSPTRP00000015172.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.40e-93	311.6	164	507

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 164  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQ 248
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 249  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 321
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 322  STPFWPlspgsegnvvngeshmsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 408
           *877779***********************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl  
   Q: 409  ITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLD- 496
           *******************5555555555554445555**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 497  --SEGYLLFYHKQ 507
           ..********985 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MGPGWPSLSA GSRQEAPLAA GGSAYQAVGR QFQPRATALQ GPSQAKSCIC HVCGVHLNRL 60
HSCLYCVFFG CFTKKHIHEH AKAKRHNLAI DLMYGGIYCF LCQDYIYDKD MEIIAKEEQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCCGG GTTGGCCCTC ACTATCCGCG GGCTCCCGAC AGGAGGCGCC CAGCTTGCGG 60
CCGGGGGCAG CGCCTACCAG GCAGTTGGCA GGCAGTTCCA GCCCCGGGCC ACGGCACTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.57	3.00e-65	243.00
IUUC-Aml-001343	Ailuropoda melanoleuca	94.05	0.00e+00	965.00
IUUC-Atr-002653	Amborella trichopoda	39.39	8.00e-97	347.00
IUUC-Apl-003433	Anas platyrhynchos	93.39	0.00e+00	956.00
IUUC-Aca-005347	Anolis carolinensis	89.98	0.00e+00	942.00
IUUC-Aly-006565	Arabidopsis lyrata	36.36	6.00e-71	261.00
IUUC-Ath-007536	Arabidopsis thaliana	36.59	3.00e-71	262.00
IUUC-Ago-007811	Ashbya gossypii	31.36	2.00e-53	202.00
IUUC-Acl-008124	Aspergillus clavatus	31.84	1.00e-58	220.00
IUUC-Afl-008464	Aspergillus flavus	33.01	7.00e-55	207.00
IUUC-Afu-008912	Aspergillus fumigatus	31.40	1.00e-56	213.00
IUUC-Ani-009168	Aspergillus nidulans	32.49	2.00e-58	219.00
IUUC-Ang-009694	Aspergillus niger	31.25	5.00e-56	211.00
IUUC-Aor-010035	Aspergillus oryzae	35.21	1.00e-38	152.00
IUUC-Ate-010382	Aspergillus terreus	31.81	8.00e-53	200.00
IUUC-Ame-011253	Astyanax mexicanus	84.19	0.00e+00	847.00
IUUC-Bgr-012150	Blumeria graminis	30.79	1.00e-48	187.00
IUUC-Bta-013303	Bos taurus	94.66	0.00e+00	971.00
IUUC-Bci-013604	Botrytis cinerea	32.68	2.00e-57	216.00
IUUC-Bdi-014171	Brachypodium distachyon	35.47	3.00e-77	282.00
IUUC-Bol-016509	Brassica oleracea	37.18	3.00e-72	266.00
IUUC-Bra-016962	Brassica rapa	36.55	2.00e-71	263.00
IUUC-Cja-019283	Callithrix jacchus	99.53	0.00e+00	890.00
IUUC-Cfa-021239	Canis familiaris	97.87	0.00e+00	973.00
IUUC-Cpo-022354	Cavia porcellus	95.07	0.00e+00	970.00
IUUC-Csa-023145	Chlorocebus sabaeus	96.30	0.00e+00	984.00
IUUC-Cho-024938	Choloepus hoffmanni	97.41	3.00e-67	249.00
IUUC-Cin-025109	Ciona intestinalis	57.67	3.00e-122	431.00
IUUC-Csv-026214	Ciona savignyi	57.46	6.00e-169	587.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	32.53	6.00e-56	211.00
IUUC-Cne-027085	Cryptococcus neoformans	32.75	1.00e-62	234.00
IUUC-Dre-027433	Danio rerio	93.80	0.00e+00	930.00
IUUC-Dno-030095	Dasypus novemcinctus	97.65	0.00e+00	974.00
IUUC-Dor-030481	Dipodomys ordii	97.11	2.00e-101	362.00
IUUC-Dse-031415	Dothistroma septosporum	31.96	7.00e-61	228.00
IUUC-Dme-032074	Drosophila melanogaster	52.75	1.00e-133	469.00
IUUC-Ete-033175	Echinops telfairi	74.70	0.00e+00	633.00
IUUC-Eca-033736	Equus caballus	97.87	0.00e+00	971.00
IUUC-Eeu-034814	Erinaceus europaeus	98.10	2.00e-122	432.00
IUUC-Fca-035861	Felis catus	98.51	0.00e+00	977.00
IUUC-Fal-037645	Ficedula albicollis	93.28	0.00e+00	939.00
IUUC-Fox-038046	Fusarium oxysporum	32.29	6.00e-57	214.00
IUUC-Fso-038321	Fusarium solani	33.33	5.00e-57	214.00
IUUC-Gmo-038474	Gadus morhua	94.26	9.00e-172	596.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.31	2.00e-57	216.00
IUUC-Gga-040624	Gallus gallus	90.44	0.00e+00	954.00
IUUC-Gac-042197	Gasterosteus aculeatus	86.85	0.00e+00	862.00
IUUC-Gma-042897	Glycine max	33.52	1.00e-82	300.00
IUUC-Ggo-044409	Gorilla gorilla	96.71	0.00e+00	988.00
IUUC-Hsa-046521	Homo sapiens	96.71	0.00e+00	987.00
IUUC-Hvu-047739	Hordeum vulgare	38.95	2.00e-70	259.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	95.07	0.00e+00	974.00
IUUC-Kpa-049135	Komagataella pastoris	35.43	1.00e-68	254.00
IUUC-Lch-050537	Latimeria chalumnae	95.52	0.00e+00	957.00
IUUC-Lpe-050969	Leersia perrieri	38.13	1.00e-72	266.00
IUUC-Loc-052765	Lepisosteus oculatus	82.74	0.00e+00	841.00
IUUC-Lma-053105	Leptosphaeria maculans	33.68	9.00e-67	247.00
IUUC-Laf-053571	Loxodonta africana	98.29	0.00e+00	974.00
IUUC-Mcc-055166	Macaca mulatta	96.30	0.00e+00	984.00
IUUC-Mor-057103	Magnaporthe oryzae	31.85	1.00e-57	216.00
IUUC-Mpo-057621	Magnaporthe poae	32.53	7.00e-57	214.00
IUUC-Mtr-057894	Medicago truncatula	39.86	5.00e-84	305.00
IUUC-Mla-059185	Melampsora laricipopulina	30.41	1.00e-43	170.00
IUUC-Mga-059709	Meleagris gallopavo	93.39	0.00e+00	956.00
IUUC-Mvi-060530	Microbotryum violaceum	34.63	4.00e-59	222.00
IUUC-Mmr-060988	Microcebus murinus	95.48	0.00e+00	979.00
IUUC-Mdo-063065	Monodelphis domestica	96.16	0.00e+00	963.00
IUUC-Mmu-063829	Mus musculus	95.28	0.00e+00	976.00
IUUC-Mpu-066687	Mustela putorius furo	94.47	0.00e+00	967.00
IUUC-Mlu-067330	Myotis lucifugus	84.21	0.00e+00	837.00
IUUC-Nfi-068423	Neosartorya fischeri	31.40	1.00e-56	214.00
IUUC-Ncr-068809	Neurospora crassa	31.30	1.00e-58	221.00
IUUC-Nle-069261	Nomascus leucogenys	91.99	0.00e+00	927.00
IUUC-Opr-070469	Ochotona princeps	79.91	0.00e+00	690.00
IUUC-Ont-071961	Oreochromis niloticus	91.04	0.00e+00	903.00
IUUC-Oan-073565	Ornithorhynchus anatinus	86.35	0.00e+00	922.00
IUUC-Ocu-074435	Oryctolagus cuniculus	95.57	0.00e+00	949.00
IUUC-Oba-075688	Oryza barthii	35.99	1.00e-76	280.00
IUUC-Obr-076652	Oryza brachyantha	41.69	4.00e-75	274.00
IUUC-Ogl-077910	Oryza glaberrima	35.89	5.00e-79	288.00
IUUC-Ogu-078479	Oryza glumaepatula	35.89	5.00e-79	288.00
IUUC-Oin-079697	Oryza indica	39.66	2.00e-76	279.00
IUUC-Olo-080811	Oryza longistaminata	41.38	2.00e-53	202.00
IUUC-Ome-081706	Oryza meridionalis	35.89	2.00e-78	286.00
IUUC-Oni-083070	Oryza nivara	35.48	6.00e-79	288.00
IUUC-Opu-083605	Oryza punctata	40.16	5.00e-68	251.00
IUUC-Oru-084522	Oryza rufipogon	35.89	5.00e-79	288.00
IUUC-Osa-085351	Oryza sativa	39.36	7.00e-77	281.00
IUUC-Ola-086743	Oryzias latipes	88.31	0.00e+00	757.00
IUUC-Olu-087695	Ostreococcus lucimarinus	31.54	4.00e-50	191.00
IUUC-Oga-089131	Otolemur garnettii	91.85	0.00e+00	963.00
IUUC-Oar-089319	Ovis aries	97.86	0.00e+00	969.00
IUUC-Pan-092927	Papio anubis	96.51	0.00e+00	985.00
IUUC-Psi-093670	Pelodiscus sinensis	93.37	0.00e+00	953.00
IUUC-Pma-094323	Petromyzon marinus	71.55	0.00e+00	721.00
IUUC-Pno-095141	Phaeosphaeria nodorum	32.05	4.00e-57	215.00
IUUC-Ppa-095413	Physcomitrella patens	41.12	2.00e-77	283.00
IUUC-Pfo-096462	Poecilia formosa	93.01	0.00e+00	931.00
IUUC-Pab-097612	Pongo abelii	96.51	0.00e+00	986.00
IUUC-Pop-099558	Populus trichocarpa	36.25	3.00e-86	312.00
IUUC-Pca-100329	Procavia capensis	84.00	0.00e+00	835.00
IUUC-Ppe-102020	Prunus persica	36.20	2.00e-88	320.00
IUUC-Pva-102721	Pteropus vampyrus	79.37	0.00e+00	774.00
IUUC-Pgr-103657	Puccinia graminis	27.93	3.00e-38	153.00
IUUC-Pte-104340	Pyrenophora teres	33.18	8.00e-59	221.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	34.83	2.00e-66	246.00
IUUC-Rno-105247	Rattus norvegicus	95.28	0.00e+00	977.00
IUUC-Sce-106247	Saccharomyces cerevisiae	31.82	5.00e-52	198.00
IUUC-Sha-107538	Sarcophilus harrisii	95.85	1.00e-124	437.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	35.11	2.00e-66	246.00
IUUC-Spo-108226	Schizosaccharomyces pombe	32.48	2.00e-60	226.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.14	6.00e-55	208.00
IUUC-Smo-109310	Selaginella moellendorffii	36.58	7.00e-85	308.00
IUUC-Sit-109716	Setaria italica	35.63	7.00e-80	291.00
IUUC-Sly-111077	Solanum lycopersicum	38.72	5.00e-79	288.00
IUUC-Stu-112203	Solanum tuberosum	40.09	5.00e-75	274.00
IUUC-Sar-113341	Sorex araneus	86.29	0.00e+00	755.00
IUUC-Sbi-114205	Sorghum bicolor	35.14	4.00e-81	295.00
IUUC-Ssc-115315	Sus scrofa	82.27	0.00e+00	835.00
IUUC-Tgu-116938	Taeniopygia guttata	96.38	0.00e+00	964.00
IUUC-Tru-117622	Takifugu rubripes	88.71	0.00e+00	924.00
IUUC-Tsy-119431	Tarsius syrichta	86.11	0.00e+00	821.00
IUUC-Tni-120119	Tetraodon nigroviridis	91.29	0.00e+00	930.00
IUUC-Tca-121154	Theobroma cacao	39.05	2.00e-89	323.00
IUUC-Tre-122139	Trichoderma reesei	31.66	2.00e-55	209.00
IUUC-Tvi-122599	Trichoderma virens	32.15	3.00e-56	212.00
IUUC-Tae-125608	Triticum aestivum	35.35	4.00e-86	311.00
IUUC-Tme-127115	Tuber melanosporum	39.03	2.00e-82	300.00
IUUC-Ttr-129006	Tursiops truncatus	84.09	0.00e+00	819.00
IUUC-Uma-129455	Ustilago maydis	32.63	5.00e-34	139.00
IUUC-Vda-129829	Verticillium dahliae	32.79	3.00e-36	145.00
IUUC-Xtr-132444	Xenopus tropicalis	92.15	0.00e+00	943.00
IUUC-Xma-133514	Xiphophorus maculatus	91.89	0.00e+00	938.00
IUUC-Yli-134357	Yarrowia lipolytica	30.81	3.00e-48	186.00
IUUC-Zma-134945	Zea mays	35.15	4.00e-77	282.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence