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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046712
UUCD1 version UUC-HoS-00050
Ensembl Protein ID ENSP00000348769.4
UniProt Accession O95376; Q9HBZ6; Q9UEM9; ARI2_HUMAN
Genbank Protein ID AAC82469.1; CAA10276.1; AAG09696.1; AAH00422.1
Protein Name E3 ubiquitin-protein ligase ARIH2; RING-type E3 ubiquitin transferase ARIH2; Triad1 protein
Genbank Nucleotide ID AF099149; AJ130978; AF183427; BC000422
Gene Name ARIH2; ARI2; TRIAD1; HT005
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000177479.19 ENST00000356401.8 ENSP00000348769.4
ENSG00000177479.19 ENST00000452385.5 ENSP00000403845.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 20226183; 19664228
Classification
Family E-value Score Start End
E3 activity/RBR 1.10e-55 189.2 139 326
Active Site
Position(s) Description Evidence
310 N/A {ECO:0000305|PubMed:24076655}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C+vC+ ++  +e++ +l+C+h+fC++C++q++++ +k+g  + +sc+a++cp +++e+ +  ll++eel ++y+++l++++ve++++l++
   Q: 139  CAVCM-QFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQL 227
           9***9.77777888899************************************************************************* PP
   S: 91   cpapdCslvvllekeaeklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyieknegCnhm 180
           cp +dC +v+++++  ++ +v+c++c+++fC++C++++H++++C +++++l+k++   +++e++++++a++k+CpkC+++iekn+gCnhm
   Q: 228  CPGADCPMVIRVQEP-RARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCA---DDSETANYISAHTKDCPKCNICIEKNGGCNHM 313
           **************7.99*************************************...99****************************** PP
   S: 181  tCakCkaefCwlC 193
           +C+kCk++fCw+C
   Q: 314  QCSKCKHDFCWMC 326
           ************* PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).
 E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006).
Protein Sequence
(Fasta)
MSVDMNSQGS DSNEEDYDPN CEEEEEEEED DPGDIEDYYV GVASDVEQQG ADAFDPEEYQ 60
FTCLTYKESE GALNEHMTSL ASVLKVSHSV AKLILVNFHW QVSEILDRYK SNSAQLLVEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046712|E3,RBR|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCAACGGCGC CAAGCACTTC CGGAGCTGTG GGGACGACTC TTCTGGAGGA AGCAGCGCGG 60
GCTTGACCGG CGTCGGCCCG CCGCCTCCGC TGCCGCTTCG CCCCAATCCG GTCCCTCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046712|E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0048588--P:developmental cell growth
GO:0071425--P:hematopoietic stem cell proliferation
GO:0007275--P:multicellular organism development
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:10425
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001557 Ailuropoda melanoleuca 97.97 0.00e+00 936.00
IUUC-Apl-003878 Anas platyrhynchos 92.90 0.00e+00 875.00
IUUC-Aca-004865 Anolis carolinensis 92.09 0.00e+00 880.00
IUUC-Bta-012901 Bos taurus 97.77 0.00e+00 932.00
IUUC-Bra-017081 Brassica rapa 28.97 1.00e-57 218.00
IUUC-Cel-018334 Caenorhabditis elegans 48.64 7.00e-127 447.00
IUUC-Cja-019728 Callithrix jacchus 98.99 0.00e+00 939.00
IUUC-Cfa-020953 Canis familiaris 98.17 0.00e+00 936.00
IUUC-Cpo-021445 Cavia porcellus 98.38 0.00e+00 937.00
IUUC-Csa-023769 Chlorocebus sabaeus 99.19 0.00e+00 944.00
IUUC-Cho-024650 Choloepus hoffmanni 87.42 0.00e+00 792.00
IUUC-Cin-025577 Ciona intestinalis 54.55 2.00e-143 502.00
IUUC-Csv-025849 Ciona savignyi 55.84 3.00e-120 424.00
IUUC-Dre-028490 Danio rerio 79.44 0.00e+00 777.00
IUUC-Dno-029942 Dasypus novemcinctus 97.97 0.00e+00 933.00
IUUC-Dor-030134 Dipodomys ordii 84.98 8.00e-151 526.00
IUUC-Dme-031853 Drosophila melanogaster 55.06 3.00e-149 521.00
IUUC-Ete-032355 Echinops telfairi 89.27 0.00e+00 835.00
IUUC-Eca-033440 Equus caballus 98.17 0.00e+00 937.00
IUUC-Eeu-035230 Erinaceus europaeus 89.36 3.00e-115 408.00
IUUC-Fca-036308 Felis catus 91.90 0.00e+00 867.00
IUUC-Fal-036974 Ficedula albicollis 92.90 0.00e+00 875.00
IUUC-Gmo-038642 Gadus morhua 81.11 0.00e+00 783.00
IUUC-Gga-041019 Gallus gallus 92.90 0.00e+00 875.00
IUUC-Gac-042014 Gasterosteus aculeatus 80.28 0.00e+00 803.00
IUUC-Ggo-045329 Gorilla gorilla 99.59 0.00e+00 946.00
IUUC-Itr-048370 Ictidomys tridecemlineatus 99.04 0.00e+00 844.00
IUUC-Lch-049584 Latimeria chalumnae 85.43 0.00e+00 824.00
IUUC-Loc-051826 Lepisosteus oculatus 80.16 3.00e-167 581.00
IUUC-Laf-054567 Loxodonta africana 96.96 0.00e+00 931.00
IUUC-Mcc-054919 Macaca mulatta 99.19 0.00e+00 944.00
IUUC-Meu-056332 Macropus eugenii 90.87 0.00e+00 849.00
IUUC-Mga-060132 Meleagris gallopavo 92.93 0.00e+00 880.00
IUUC-Mmr-061599 Microcebus murinus 94.74 0.00e+00 886.00
IUUC-Mdo-062186 Monodelphis domestica 94.93 0.00e+00 801.00
IUUC-Mmu-064271 Mus musculus 97.77 0.00e+00 932.00
IUUC-Mpu-066827 Mustela putorius furo 96.67 0.00e+00 828.00
IUUC-Mlu-067528 Myotis lucifugus 96.96 0.00e+00 892.00
IUUC-Nle-068995 Nomascus leucogenys 99.59 0.00e+00 946.00
IUUC-Opr-070518 Ochotona princeps 98.17 0.00e+00 900.00
IUUC-Ont-071650 Oreochromis niloticus 83.27 0.00e+00 822.00
IUUC-Oan-073676 Ornithorhynchus anatinus 93.87 0.00e+00 752.00
IUUC-Ocu-073761 Oryctolagus cuniculus 99.19 0.00e+00 943.00
IUUC-Obr-076705 Oryza brachyantha 30.05 1.00e-58 221.00
IUUC-Ola-087204 Oryzias latipes 79.76 0.00e+00 795.00
IUUC-Oga-088098 Otolemur garnettii 98.38 0.00e+00 933.00
IUUC-Oar-089205 Ovis aries 97.77 0.00e+00 932.00
IUUC-Ptr-091514 Pan troglodytes 99.59 0.00e+00 946.00
IUUC-Pan-092493 Papio anubis 94.43 0.00e+00 899.00
IUUC-Psi-093024 Pelodiscus sinensis 87.50 2.00e-117 414.00
IUUC-Pfo-097256 Poecilia formosa 82.04 0.00e+00 813.00
IUUC-Pab-098504 Pongo abelii 91.89 0.00e+00 845.00
IUUC-Pop-099547 Populus trichocarpa 30.85 2.00e-55 210.00
IUUC-Pca-100700 Procavia capensis 91.08 0.00e+00 836.00
IUUC-Pva-103105 Pteropus vampyrus 97.16 0.00e+00 921.00
IUUC-Rno-105289 Rattus norvegicus 97.97 0.00e+00 932.00
IUUC-Sha-107417 Sarcophilus harrisii 94.93 0.00e+00 871.00
IUUC-Sar-113042 Sorex araneus 95.98 0.00e+00 924.00
IUUC-Ssc-115362 Sus scrofa 98.38 0.00e+00 937.00
IUUC-Tgu-117469 Taeniopygia guttata 92.55 0.00e+00 828.00
IUUC-Tru-117976 Takifugu rubripes 80.39 0.00e+00 816.00
IUUC-Tsy-118876 Tarsius syrichta 85.45 2.00e-95 343.00
IUUC-Tni-119831 Tetraodon nigroviridis 80.39 0.00e+00 793.00
IUUC-Tca-121326 Theobroma cacao 29.14 6.00e-60 225.00
IUUC-Tbe-127386 Tupaia belangeri 91.88 7.00e-161 560.00
IUUC-Ttr-128315 Tursiops truncatus 97.97 0.00e+00 936.00
IUUC-Vpa-130383 Vicugna pacos 90.47 0.00e+00 836.00
IUUC-Xtr-132945 Xenopus tropicalis 90.67 0.00e+00 871.00
Created Date 25-Jun-2017

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