iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044708

UUCD1 version

UUC-GoG-01084

Ensembl Protein ID

ENSGGOP00000014542.2

UniProt Accession

G3RG07; G3RG07_GORGO

Protein Name

Uncharacterized protein

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000014895.2	ENSGGOT00000030871.1	ENSGGOP00000019802.1
ENSGGOG00000014895.2	ENSGGOT00000014955.2	ENSGGOP00000014542.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.90e-115	384.5	598	1315

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 598  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 684
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 685  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 769
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 770  FLYLPVPLPQKQKVLPVfyfarephskpikflvsvskenstasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsd 856
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 857  vllcfellsselakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 943
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 944  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstgsleagdserdpiqppelqlvtlmaegdtglprv 1030
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1031 waapdrgpvpstsgissemlasgpievgslpagervsrpeaavpgyqhpseamnahtpqffiykidssnreqrledkgdtplelgdd 1117
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1118 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1204
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1205 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1288
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1289 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1315
           ****************...********996 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGDPR KETGSRYVAQ AGLELLASGD 60
PSASASHAAG ITGSRHHTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPPPELLLDW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGACCTGA CGCCGGAACC GGAACGGAGA GCGGGTTGCC AGGGCCCGAA GAGGGCTGGC 60
TGCGGCGGTC TCGCTCGGTG AGTGGAGCAG GCTGCAACTC GCCGGCTTGG CCACAGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	89.76	0.00e+00	2274.00
IUUC-Apl-003368	Anas platyrhynchos	67.54	0.00e+00	1717.00
IUUC-Aca-004267	Anolis carolinensis	65.72	0.00e+00	1607.00
IUUC-Ame-010970	Astyanax mexicanus	70.81	0.00e+00	1330.00
IUUC-Bta-012905	Bos taurus	89.01	0.00e+00	2288.00
IUUC-Cel-018257	Caenorhabditis elegans	43.00	1.00e-91	331.00
IUUC-Cja-018789	Callithrix jacchus	96.34	0.00e+00	2618.00
IUUC-Cfa-021004	Canis familiaris	89.99	0.00e+00	2290.00
IUUC-Cpo-021529	Cavia porcellus	85.93	0.00e+00	2343.00
IUUC-Csa-024035	Chlorocebus sabaeus	97.72	0.00e+00	2348.00
IUUC-Cho-025036	Choloepus hoffmanni	79.36	0.00e+00	1206.00
IUUC-Cin-025451	Ciona intestinalis	43.15	1.00e-84	308.00
IUUC-Csv-025931	Ciona savignyi	36.44	8.00e-110	390.00
IUUC-Dre-028556	Danio rerio	68.14	0.00e+00	1315.00
IUUC-Dno-029240	Dasypus novemcinctus	88.93	0.00e+00	2131.00
IUUC-Dor-030495	Dipodomys ordii	95.26	0.00e+00	1290.00
IUUC-Ete-032741	Echinops telfairi	92.23	0.00e+00	1852.00
IUUC-Eca-033661	Equus caballus	89.64	0.00e+00	2398.00
IUUC-Eeu-034648	Erinaceus europaeus	89.96	0.00e+00	808.00
IUUC-Fca-035646	Felis catus	89.39	0.00e+00	2265.00
IUUC-Fal-037094	Ficedula albicollis	67.48	0.00e+00	1725.00
IUUC-Gmo-038869	Gadus morhua	72.10	0.00e+00	844.00
IUUC-Gga-041170	Gallus gallus	65.78	0.00e+00	1676.00
IUUC-Gac-041901	Gasterosteus aculeatus	64.05	0.00e+00	1316.00
IUUC-Hsa-046791	Homo sapiens	98.84	0.00e+00	2176.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	88.67	0.00e+00	2357.00
IUUC-Lch-050456	Latimeria chalumnae	50.85	0.00e+00	1186.00
IUUC-Loc-052861	Lepisosteus oculatus	61.55	0.00e+00	1129.00
IUUC-Laf-053788	Loxodonta africana	87.76	0.00e+00	2309.00
IUUC-Mcc-055693	Macaca mulatta	96.86	0.00e+00	2550.00
IUUC-Meu-055921	Macropus eugenii	78.63	0.00e+00	1517.00
IUUC-Mga-059879	Meleagris gallopavo	65.87	0.00e+00	1737.00
IUUC-Mmr-060802	Microcebus murinus	91.54	0.00e+00	2455.00
IUUC-Mdo-061856	Monodelphis domestica	79.29	0.00e+00	1626.00
IUUC-Mmu-063874	Mus musculus	86.65	0.00e+00	2338.00
IUUC-Mpu-066166	Mustela putorius furo	89.72	0.00e+00	2274.00
IUUC-Nle-070161	Nomascus leucogenys	98.59	0.00e+00	2741.00
IUUC-Opr-071015	Ochotona princeps	92.67	0.00e+00	1918.00
IUUC-Ont-072308	Oreochromis niloticus	70.01	0.00e+00	1358.00
IUUC-Oan-072723	Ornithorhynchus anatinus	65.85	0.00e+00	1590.00
IUUC-Ocu-073938	Oryctolagus cuniculus	89.92	0.00e+00	2257.00
IUUC-Ola-086375	Oryzias latipes	61.23	0.00e+00	1375.00
IUUC-Oga-088297	Otolemur garnettii	90.72	0.00e+00	2387.00
IUUC-Oar-089675	Ovis aries	83.28	0.00e+00	2007.00
IUUC-Ptr-091621	Pan troglodytes	98.76	0.00e+00	2177.00
IUUC-Pan-092118	Papio anubis	95.45	0.00e+00	2486.00
IUUC-Pma-094154	Petromyzon marinus	51.78	2.00e-114	405.00
IUUC-Pfo-097246	Poecilia formosa	59.13	0.00e+00	1390.00
IUUC-Pab-098551	Pongo abelii	97.96	0.00e+00	2147.00
IUUC-Pca-100158	Procavia capensis	83.67	0.00e+00	2253.00
IUUC-Pva-103160	Pteropus vampyrus	89.03	0.00e+00	2348.00
IUUC-Rno-105355	Rattus norvegicus	86.96	0.00e+00	2348.00
IUUC-Sha-107057	Sarcophilus harrisii	72.88	0.00e+00	1821.00
IUUC-Sar-113011	Sorex araneus	89.38	0.00e+00	1499.00
IUUC-Ssc-115761	Sus scrofa	89.69	0.00e+00	2323.00
IUUC-Tgu-116956	Taeniopygia guttata	62.30	0.00e+00	835.00
IUUC-Tru-118739	Takifugu rubripes	69.15	0.00e+00	1344.00
IUUC-Tsy-118827	Tarsius syrichta	81.56	0.00e+00	1250.00
IUUC-Tni-119921	Tetraodon nigroviridis	58.68	0.00e+00	1380.00
IUUC-Tbe-128017	Tupaia belangeri	91.94	0.00e+00	1986.00
IUUC-Ttr-128869	Tursiops truncatus	88.04	0.00e+00	2324.00
IUUC-Vpa-130427	Vicugna pacos	95.51	0.00e+00	925.00
IUUC-Xtr-132734	Xenopus tropicalis	61.26	0.00e+00	1560.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence