iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	23827681

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.00033	22.3	233	266

Active Site

Position(s)	Description	Evidence
73	N/A	{ECO:0000250}
76	Nucleophile	ECO:0000250}
182		{ECO:0000250}

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlve.MGF.dreealqaLraannnleaAv 35
           ed++++ ++ +G+ d+++++q L+a+n+n+e A+
   Q: 233  EDAVQKVCNaTGCsDFNLIVQNLEAENYNIESAI 266
           89*****************************997 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.

Protein Sequence
(Fasta)

MSRKQAAKSR PGSGSRKAEA ERKRDERAAR RALAKERRNR PESGGGGGCE EEFVSFANQL 60
QALGLKLREV PGDGNCLFRA LGDQLEGHSR NHLKHRQETV DYMIKQREDF EPFVEDDIPF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATGTCCCGA AAGCAGGCGG CGAAGAGCCG GCCGGGCAGC GGCAGCCGGA AAGCCGAGGC 60
CGAGCGCAAG CGGGACGAGC GGGCGGCGCG CCGGGCCCTG GCCAAGGAGC GGCGGAATCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0050821--P:protein stabilization

KEGG

hsa:23252

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000676	Aegilops tauschii	33.87	9.00e-34	137.00
IUUC-Aml-001610	Ailuropoda melanoleuca	85.34	2.00e-147	515.00
IUUC-Atr-002622	Amborella trichopoda	35.52	6.00e-38	151.00
IUUC-Apl-004076	Anas platyrhynchos	61.01	1.00e-104	372.00
IUUC-Aly-006098	Arabidopsis lyrata	46.48	1.00e-35	144.00
IUUC-Ath-006727	Arabidopsis thaliana	46.48	2.00e-35	143.00
IUUC-Ame-010833	Astyanax mexicanus	72.28	9.00e-73	267.00
IUUC-Bta-013444	Bos taurus	89.95	2.00e-178	618.00
IUUC-Bdi-014363	Brachypodium distachyon	37.67	3.00e-40	159.00
IUUC-Bol-015165	Brassica oleracea	46.48	3.00e-36	145.00
IUUC-Bra-017512	Brassica rapa	45.77	2.00e-35	143.00
IUUC-Cja-019676	Callithrix jacchus	87.94	5.00e-170	590.00
IUUC-Cfa-020420	Canis familiaris	94.22	0.00e+00	647.00
IUUC-Cpo-021542	Cavia porcellus	90.45	3.00e-171	594.00
IUUC-Cre-022598	Chlamydomonas reinhardtii	36.36	2.00e-34	139.00
IUUC-Csa-024221	Chlorocebus sabaeus	98.24	0.00e+00	698.00
IUUC-Cho-024571	Choloepus hoffmanni	71.57	1.00e-78	286.00
IUUC-Cin-025437	Ciona intestinalis	43.00	3.00e-63	235.00
IUUC-Cne-027062	Cryptococcus neoformans	46.15	2.00e-11	63.90
IUUC-Cme-027120	Cyanidioschyzon merolae	31.76	2.00e-18	85.90
IUUC-Dre-027837	Danio rerio	73.27	1.00e-73	270.00
IUUC-Dno-029992	Dasypus novemcinctus	91.21	0.00e+00	634.00
IUUC-Dor-031023	Dipodomys ordii	78.59	2.00e-119	422.00
IUUC-Dse-031192	Dothistroma septosporum	28.51	9.00e-17	81.60
IUUC-Ete-032971	Echinops telfairi	67.09	5.00e-104	371.00
IUUC-Eca-034055	Equus caballus	93.06	5.00e-179	619.00
IUUC-Eeu-035085	Erinaceus europaeus	66.23	2.00e-52	199.00
IUUC-Fca-035510	Felis catus	89.85	3.00e-153	534.00
IUUC-Fal-037522	Ficedula albicollis	61.47	4.00e-119	421.00
IUUC-Gmo-038654	Gadus morhua	67.82	4.00e-70	258.00
IUUC-Gga-040831	Gallus gallus	62.84	4.00e-104	371.00
IUUC-Gac-042037	Gasterosteus aculeatus	50.14	1.00e-69	256.00
IUUC-Gma-043851	Glycine max	34.58	1.00e-32	134.00
IUUC-Ggo-045446	Gorilla gorilla	83.09	5.00e-160	557.00
IUUC-Hvu-047137	Hordeum vulgare	37.33	5.00e-38	151.00
IUUC-Itr-048577	Ictidomys tridecemlineatus	91.41	2.00e-166	577.00
IUUC-Lch-049440	Latimeria chalumnae	58.59	5.00e-104	371.00
IUUC-Lpe-050983	Leersia perrieri	39.04	8.00e-37	147.00
IUUC-Loc-052084	Lepisosteus oculatus	51.36	2.00e-78	286.00
IUUC-Laf-054509	Loxodonta africana	92.21	0.00e+00	647.00
IUUC-Mcc-055100	Macaca mulatta	96.61	2.00e-90	323.00
IUUC-Meu-056580	Macropus eugenii	65.33	8.00e-116	410.00
IUUC-Mtr-057856	Medicago truncatula	43.66	1.00e-33	137.00
IUUC-Mga-060062	Meleagris gallopavo	63.27	1.00e-106	379.00
IUUC-Mmr-060638	Microcebus murinus	94.72	0.00e+00	651.00
IUUC-Mdo-062294	Monodelphis domestica	76.05	1.00e-152	532.00
IUUC-Mmu-063414	Mus musculus	82.91	2.00e-160	558.00
IUUC-Mac-065203	Musa acuminata	51.58	6.00e-25	109.00
IUUC-Mpu-066357	Mustela putorius furo	93.47	0.00e+00	642.00
IUUC-Mlu-068043	Myotis lucifugus	89.24	7.00e-178	616.00
IUUC-Nle-069696	Nomascus leucogenys	98.73	0.00e+00	692.00
IUUC-Opr-070471	Ochotona princeps	72.92	7.00e-120	423.00
IUUC-Ont-071796	Oreochromis niloticus	78.00	1.00e-72	266.00
IUUC-Oan-073053	Ornithorhynchus anatinus	76.98	9.00e-101	359.00
IUUC-Ocu-074959	Oryctolagus cuniculus	87.97	1.00e-172	598.00
IUUC-Oba-075820	Oryza barthii	38.29	6.00e-28	118.00
IUUC-Obr-076818	Oryza brachyantha	37.22	4.00e-37	149.00
IUUC-Ogl-077295	Oryza glaberrima	38.29	6.00e-28	118.00
IUUC-Ogu-078220	Oryza glumaepatula	37.39	3.00e-26	112.00
IUUC-Oin-080176	Oryza indica	37.84	1.00e-27	117.00
IUUC-Olo-081061	Oryza longistaminata	33.33	2.00e-16	80.10
IUUC-Ome-082004	Oryza meridionalis	36.99	4.00e-27	115.00
IUUC-Oni-082169	Oryza nivara	34.39	4.00e-18	85.90
IUUC-Opu-083319	Oryza punctata	36.94	2.00e-27	117.00
IUUC-Oru-084638	Oryza rufipogon	37.84	1.00e-27	117.00
IUUC-Osa-085511	Oryza sativa	46.15	1.00e-25	109.00
IUUC-Ola-086377	Oryzias latipes	69.80	5.00e-74	271.00
IUUC-Olu-087677	Ostreococcus lucimarinus	36.50	1.00e-17	83.60
IUUC-Oga-087948	Otolemur garnettii	85.68	1.00e-159	555.00
IUUC-Oar-089738	Ovis aries	84.10	5.00e-158	550.00
IUUC-Ptr-091573	Pan troglodytes	99.50	0.00e+00	706.00
IUUC-Pan-092308	Papio anubis	96.98	0.00e+00	671.00
IUUC-Psi-093215	Pelodiscus sinensis	69.70	2.00e-100	358.00
IUUC-Pno-095148	Phaeosphaeria nodorum	31.82	7.00e-11	61.20
IUUC-Ppa-095671	Physcomitrella patens	44.06	1.00e-32	135.00
IUUC-Pfo-096080	Poecilia formosa	70.79	2.00e-71	262.00
IUUC-Pab-098297	Pongo abelii	96.93	0.00e+00	629.00
IUUC-Pop-099083	Populus trichocarpa	43.45	1.00e-33	137.00
IUUC-Pca-100767	Procavia capensis	82.41	5.00e-143	500.00
IUUC-Pva-103136	Pteropus vampyrus	86.72	9.00e-173	599.00
IUUC-Pgr-103365	Puccinia graminis	37.62	6.00e-14	72.00
IUUC-Rno-105390	Rattus norvegicus	79.70	1.00e-150	525.00
IUUC-Sha-106882	Sarcophilus harrisii	82.07	9.00e-139	486.00
IUUC-Ssl-108547	Sclerotinia sclerotiorum	27.74	2.00e-12	66.60
IUUC-Sit-109684	Setaria italica	38.99	2.00e-40	159.00
IUUC-Sly-111374	Solanum lycopersicum	36.21	2.00e-33	136.00
IUUC-Stu-112721	Solanum tuberosum	36.97	3.00e-35	142.00
IUUC-Sar-113367	Sorex araneus	87.35	9.00e-157	546.00
IUUC-Sbi-114765	Sorghum bicolor	37.96	8.00e-40	157.00
IUUC-Sre-115174	Sporisorium reilianum	43.75	2.00e-16	81.30
IUUC-Tgu-116990	Taeniopygia guttata	68.97	8.00e-106	376.00
IUUC-Tru-118145	Takifugu rubripes	48.43	1.00e-74	273.00
IUUC-Tsy-119102	Tarsius syrichta	90.12	9.00e-152	529.00
IUUC-Tni-119708	Tetraodon nigroviridis	75.33	1.00e-70	260.00
IUUC-Tca-121225	Theobroma cacao	32.69	2.00e-23	103.00
IUUC-Tae-123104	Triticum aestivum	39.63	3.00e-39	156.00
IUUC-Tur-126073	Triticum urartu	39.17	1.00e-38	154.00
IUUC-Tbe-127957	Tupaia belangeri	92.55	2.00e-63	236.00
IUUC-Ttr-128820	Tursiops truncatus	80.90	1.00e-148	519.00
IUUC-Uma-129319	Ustilago maydis	40.91	7.00e-18	85.90
IUUC-Vpa-130646	Vicugna pacos	74.62	1.00e-121	429.00
IUUC-Vvi-131263	Vitis vinifera	45.07	5.00e-34	138.00
IUUC-Xtr-132318	Xenopus tropicalis	50.35	3.00e-80	292.00
IUUC-Xma-133918	Xiphophorus maculatus	70.79	2.00e-71	262.00
IUUC-Yli-134572	Yarrowia lipolytica	33.95	4.00e-20	92.40
IUUC-Zma-134975	Zea mays	39.17	8.00e-40	157.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence