iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000017940.1	ENSOART00000019524.1	ENSOARP00000019256.1
ENSOARG00000017940.1	ENSOART00000019525.1	ENSOARP00000019257.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-13	50.2	93	147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++  ++++++W+ + +  +g+ G +P+n+v+ 
   Q: 93   TFVALYDYESRTETDLSFKKGERLQIV--NNTEGDWWLAHSLSTGQTGYIPSNYVAP 147
           5789***********************..8999*********************975 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MGSNKSKPKD ASQRRRSLEP AENTHRGGGG GGGGGAFPSS QTPSKPASSD GHRGPNTAFA 60
PAAAEPKLFG GFNSSDTVTS PQRAGPLAGG VTTFVALYDY ESRTETDLSF KKGERLQIVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCATGGGC AGCAACAAGA GCAAGCCCAA GGATGCCAGC CAGCGGCGCC GCAGCCTGGA 60
GCCTGCCGAG AATACCCACC GGGGCGGGGG AGGCGGCGGG CGCGGGTGGA GGTGCCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0002102--C:podosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0020037--F:heme binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0045453--P:bone resorption
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0016477--P:cell migration
GO:0071498--P:cellular response to fluid shear stress
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0030900--P:forebrain development
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0071803--P:positive regulation of podosome assembly
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0046777--P:protein autophosphorylation
GO:0031648--P:protein destabilization
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0060491--P:regulation of cell projection assembly
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	96.34	0.00e+00	1073.00
IUUC-Aca-004237	Anolis carolinensis	90.76	0.00e+00	1019.00
IUUC-Ath-007146	Arabidopsis thaliana	31.52	9.00e-22	99.00
IUUC-Ame-011887	Astyanax mexicanus	79.23	0.00e+00	884.00
IUUC-Bta-012982	Bos taurus	99.08	0.00e+00	1096.00
IUUC-Bra-017486	Brassica rapa	33.16	3.00e-20	94.40
IUUC-Cja-019995	Callithrix jacchus	96.16	0.00e+00	1065.00
IUUC-Cfa-020060	Canis familiaris	97.60	0.00e+00	1085.00
IUUC-Cpo-021557	Cavia porcellus	93.90	0.00e+00	1032.00
IUUC-Csa-023711	Chlorocebus sabaeus	96.34	0.00e+00	1065.00
IUUC-Cin-025390	Ciona intestinalis	70.11	0.00e+00	662.00
IUUC-Csv-026029	Ciona savignyi	66.60	0.00e+00	633.00
IUUC-Dre-028491	Danio rerio	81.83	0.00e+00	886.00
IUUC-Dno-029651	Dasypus novemcinctus	91.02	0.00e+00	1024.00
IUUC-Ete-033170	Echinops telfairi	95.63	0.00e+00	908.00
IUUC-Eca-033970	Equus caballus	91.34	0.00e+00	993.00
IUUC-Fca-036113	Felis catus	97.60	0.00e+00	1085.00
IUUC-Fal-036785	Ficedula albicollis	91.96	0.00e+00	1038.00
IUUC-Gga-040899	Gallus gallus	92.61	0.00e+00	1043.00
IUUC-Gac-042332	Gasterosteus aculeatus	81.33	0.00e+00	895.00
IUUC-Gma-043938	Glycine max	33.84	4.00e-22	100.00
IUUC-Ggo-044829	Gorilla gorilla	82.45	0.00e+00	872.00
IUUC-Hsa-046192	Homo sapiens	96.34	0.00e+00	1065.00
IUUC-Hvu-047855	Hordeum vulgare	30.71	1.00e-22	101.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	95.61	0.00e+00	1054.00
IUUC-Lch-049892	Latimeria chalumnae	85.95	0.00e+00	956.00
IUUC-Loc-052812	Lepisosteus oculatus	81.47	0.00e+00	890.00
IUUC-Laf-053977	Loxodonta africana	96.71	0.00e+00	1082.00
IUUC-Mcc-055159	Macaca mulatta	94.44	0.00e+00	1059.00
IUUC-Mtr-058733	Medicago truncatula	31.66	1.00e-22	102.00
IUUC-Mga-060135	Meleagris gallopavo	92.14	0.00e+00	1039.00
IUUC-Mmr-061168	Microcebus murinus	93.55	0.00e+00	1065.00
IUUC-Mdo-063030	Monodelphis domestica	89.43	0.00e+00	1027.00
IUUC-Mmu-063893	Mus musculus	95.25	0.00e+00	1074.00
IUUC-Mpu-066411	Mustela putorius furo	97.60	0.00e+00	1085.00
IUUC-Mlu-068139	Myotis lucifugus	95.98	0.00e+00	1075.00
IUUC-Nle-070178	Nomascus leucogenys	94.15	0.00e+00	1011.00
IUUC-Ont-072130	Oreochromis niloticus	81.31	0.00e+00	905.00
IUUC-Ocu-074403	Oryctolagus cuniculus	94.89	0.00e+00	1051.00
IUUC-Ola-086527	Oryzias latipes	80.76	0.00e+00	904.00
IUUC-Oga-088493	Otolemur garnettii	95.61	0.00e+00	1062.00
IUUC-Ptr-091050	Pan troglodytes	96.34	0.00e+00	1065.00
IUUC-Pan-091862	Papio anubis	97.41	0.00e+00	1070.00
IUUC-Psi-093071	Pelodiscus sinensis	92.98	0.00e+00	1047.00
IUUC-Pfo-096578	Poecilia formosa	81.49	0.00e+00	914.00
IUUC-Pab-097902	Pongo abelii	94.27	0.00e+00	1058.00
IUUC-Pop-099554	Populus trichocarpa	31.96	1.00e-22	102.00
IUUC-Ppe-102072	Prunus persica	34.89	1.00e-26	115.00
IUUC-Pva-103176	Pteropus vampyrus	81.90	0.00e+00	882.00
IUUC-Rno-105847	Rattus norvegicus	95.62	0.00e+00	1075.00
IUUC-Sha-107539	Sarcophilus harrisii	92.42	0.00e+00	1041.00
IUUC-Sly-111920	Solanum lycopersicum	31.60	1.00e-21	98.60
IUUC-Stu-112331	Solanum tuberosum	32.40	5.00e-23	103.00
IUUC-Ssc-115762	Sus scrofa	97.45	0.00e+00	1086.00
IUUC-Tru-117854	Takifugu rubripes	80.40	0.00e+00	893.00
IUUC-Tni-120843	Tetraodon nigroviridis	82.20	0.00e+00	914.00
IUUC-Tae-123192	Triticum aestivum	30.71	5.00e-22	99.80
IUUC-Ttr-128702	Tursiops truncatus	91.59	0.00e+00	1006.00
IUUC-Vvi-131181	Vitis vinifera	33.21	7.00e-22	99.40
IUUC-Xtr-132291	Xenopus tropicalis	87.11	0.00e+00	953.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence