iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046252

UUCD1 version

UUC-HoS-00919

Ensembl Protein ID

ENSP00000262395.5

UniProt Accession

Q9BUZ4; O75615; Q14848; Q2KJU4; Q2PJN8; TRAF4_HUMAN

Genbank Protein ID

CAA56491.1; AAC32376.1; AAY16990.1; ABC40750.1; AAH01769.1

Protein Name

TNF receptor-associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Metastatic lymph node gene 62 protein; RING finger protein 83

Genbank Nucleotide ID

X80200; AF082185; AY937224; DQ323999; AC010761

Gene Name

TRAF4; CART1; MLN62; RNF83

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000076604.14	ENST00000262395.9	ENSP00000262395.5
ENSG00000076604.14	ENST00000422344.5	ENSP00000415789.1
ENSG00000076604.14	ENST00000586813.5	ENSP00000466306.1
ENSG00000076604.14	ENST00000444415.7	ENSP00000438154.2
ENSG00000076604.14	ENST00000262396.10	ENSP00000262396.6
ENSG00000076604.14	ENST00000475329.5	ENSP00000464583.1
ENSG00000076604.14	ENST00000454852.6	ENSP00000396602.2
ENSG00000076604.14	ENST00000618771.1	ENSP00000481248.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.60e-06	28.0	18	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C++C  ++++++ v  CgH f+ +Clq +     +s + f+CP 
   Q: 18   CPLCGKPMREPVQVSTCGHRFCDTCLQEF-----LSEGVFKCPE 56
           ********99888888**********999.....89*******6 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.

Protein Sequence
(Fasta)

MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP 60
LDYAKIYPDP ELEVQVLGLP IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV IPCPNRCPMK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACAGCCGAG CCCTGGCCGC GACCGCCAGT CGGCGCCGCC CGGAGCCGGG AGCGCCGCTC 60
CAGCGAGGCG CGGGCTGTGG GGCCGCCGCG TGCCTGGCCC CGCTCGCCCG TGCCGGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0796--Tight junction
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027138--TRAF4
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0005923--C:bicellular tight junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0050699--F:WW domain binding
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0006915--P:apoptotic process
GO:0046330--P:positive regulation of JNK cascade
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0045860--P:positive regulation of protein kinase activity
GO:0042981--P:regulation of apoptotic process
GO:0007585--P:respiratory gaseous exchange
GO:0030323--P:respiratory tube development
GO:0007165--P:signal transduction

KEGG

hsa:9618

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001287	Ailuropoda melanoleuca	96.38	0.00e+00	897.00
IUUC-Ame-011530	Astyanax mexicanus	77.66	0.00e+00	775.00
IUUC-Bta-013582	Bos taurus	97.87	0.00e+00	919.00
IUUC-Cja-019883	Callithrix jacchus	94.79	1.00e-51	194.00
IUUC-Cfa-020133	Canis familiaris	91.70	0.00e+00	848.00
IUUC-Cpo-022021	Cavia porcellus	98.30	0.00e+00	925.00
IUUC-Csa-023199	Chlorocebus sabaeus	99.15	0.00e+00	931.00
IUUC-Dre-028193	Danio rerio	76.81	0.00e+00	771.00
IUUC-Dno-028917	Dasypus novemcinctus	98.30	0.00e+00	924.00
IUUC-Ete-032433	Echinops telfairi	97.87	0.00e+00	920.00
IUUC-Fca-036155	Felis catus	97.87	0.00e+00	920.00
IUUC-Gmo-038860	Gadus morhua	77.66	0.00e+00	774.00
IUUC-Gga-041052	Gallus gallus	80.85	0.00e+00	825.00
IUUC-Gac-041489	Gasterosteus aculeatus	77.45	0.00e+00	772.00
IUUC-Ggo-044996	Gorilla gorilla	99.79	0.00e+00	934.00
IUUC-Itr-048232	Ictidomys tridecemlineatus	98.72	0.00e+00	927.00
IUUC-Kpa-049340	Komagataella pastoris	26.46	5.00e-16	79.30
IUUC-Loc-052312	Lepisosteus oculatus	77.28	0.00e+00	769.00
IUUC-Lma-053014	Leptosphaeria maculans	22.01	5.00e-13	69.30
IUUC-Laf-054376	Loxodonta africana	98.30	0.00e+00	924.00
IUUC-Mcc-055684	Macaca mulatta	99.15	0.00e+00	931.00
IUUC-Mmr-061198	Microcebus murinus	98.72	0.00e+00	927.00
IUUC-Mdo-062585	Monodelphis domestica	86.81	0.00e+00	830.00
IUUC-Mmu-064303	Mus musculus	96.81	0.00e+00	915.00
IUUC-Mpu-066854	Mustela putorius furo	97.45	0.00e+00	916.00
IUUC-Nle-070098	Nomascus leucogenys	98.51	0.00e+00	924.00
IUUC-Ont-071518	Oreochromis niloticus	77.61	0.00e+00	773.00
IUUC-Ocu-073841	Oryctolagus cuniculus	98.51	0.00e+00	926.00
IUUC-Ola-086674	Oryzias latipes	77.40	0.00e+00	771.00
IUUC-Oga-088510	Otolemur garnettii	98.30	0.00e+00	924.00
IUUC-Oar-089225	Ovis aries	94.68	0.00e+00	880.00
IUUC-Pan-092725	Papio anubis	99.15	0.00e+00	931.00
IUUC-Pfo-096341	Poecilia formosa	77.40	0.00e+00	773.00
IUUC-Pva-103131	Pteropus vampyrus	98.47	2.00e-142	499.00
IUUC-Rno-105996	Rattus norvegicus	97.02	0.00e+00	915.00
IUUC-Sly-111800	Solanum lycopersicum	30.00	9.00e-06	47.00
IUUC-Tru-117602	Takifugu rubripes	77.66	0.00e+00	776.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence