iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-063080

Ensembl Protein ID

ENSMODP00000003094.2

UniProt Accession

F7ALW1; F7ALW1_MONDO

Protein Name

Uncharacterized protein

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002546.3	ENSMODT00000003160.3	ENSMODP00000003094.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.30e-44	147.9	196	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++ vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+ +g  Gl+P+n+v+ l
   Q: 196  VLHIVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNSRGLIGLVPKNYVVIL 255
           5789**************************************.7**************866 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANKTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSTRDAS PTPSTDAEYP SNGSTADRIY DLNIPAYVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCACCTTG ATGCTGATCA ACTTATGTGC CCATCTGTTG CTGTAAAAGC TTTCCTTGCC 60
ACTCTGGAGA AACATCTTCA AGCAACACCT GAGATACCAT TATTTTTGGA AAGCAAGTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

KEGG

mdo:100014693

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	91.58	0.00e+00	720.00
IUUC-Apl-003456	Anas platyrhynchos	96.58	0.00e+00	746.00
IUUC-Aca-005105	Anolis carolinensis	96.32	0.00e+00	744.00
IUUC-Ame-010966	Astyanax mexicanus	78.39	3.00e-175	607.00
IUUC-Bta-012424	Bos taurus	84.21	0.00e+00	630.00
IUUC-Cja-019898	Callithrix jacchus	91.58	0.00e+00	721.00
IUUC-Cfa-020830	Canis familiaris	90.53	0.00e+00	714.00
IUUC-Cpo-021487	Cavia porcellus	82.89	0.00e+00	630.00
IUUC-Csa-023693	Chlorocebus sabaeus	91.84	0.00e+00	724.00
IUUC-Cin-025348	Ciona intestinalis	39.02	8.00e-70	257.00
IUUC-Dre-028334	Danio rerio	82.25	1.00e-180	625.00
IUUC-Dno-028973	Dasypus novemcinctus	92.63	0.00e+00	723.00
IUUC-Dor-031003	Dipodomys ordii	89.47	0.00e+00	679.00
IUUC-Ete-032792	Echinops telfairi	83.85	0.00e+00	651.00
IUUC-Eca-033656	Equus caballus	91.58	0.00e+00	720.00
IUUC-Fca-036347	Felis catus	91.58	0.00e+00	719.00
IUUC-Fal-037095	Ficedula albicollis	97.11	0.00e+00	748.00
IUUC-Gmo-039410	Gadus morhua	69.90	1.00e-161	562.00
IUUC-Gga-040155	Gallus gallus	96.58	0.00e+00	746.00
IUUC-Gac-041787	Gasterosteus aculeatus	72.59	5.00e-166	577.00
IUUC-Ggo-044805	Gorilla gorilla	91.84	0.00e+00	722.00
IUUC-Hsa-046585	Homo sapiens	91.84	0.00e+00	722.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	90.26	0.00e+00	694.00
IUUC-Lch-049795	Latimeria chalumnae	91.05	0.00e+00	708.00
IUUC-Loc-051985	Lepisosteus oculatus	90.26	0.00e+00	675.00
IUUC-Laf-054228	Loxodonta africana	93.95	0.00e+00	730.00
IUUC-Mcc-055402	Macaca mulatta	91.84	0.00e+00	724.00
IUUC-Mga-059374	Meleagris gallopavo	96.58	0.00e+00	746.00
IUUC-Mmr-061453	Microcebus murinus	91.58	0.00e+00	719.00
IUUC-Mmu-063529	Mus musculus	88.68	0.00e+00	691.00
IUUC-Mpu-066815	Mustela putorius furo	91.58	0.00e+00	720.00
IUUC-Mlu-067132	Myotis lucifugus	87.21	2.00e-156	545.00
IUUC-Nle-069371	Nomascus leucogenys	91.84	0.00e+00	722.00
IUUC-Opr-070948	Ochotona princeps	91.25	0.00e+00	682.00
IUUC-Ont-071410	Oreochromis niloticus	75.31	1.00e-164	572.00
IUUC-Oan-073304	Ornithorhynchus anatinus	95.10	5.00e-169	586.00
IUUC-Ocu-074783	Oryctolagus cuniculus	91.05	0.00e+00	699.00
IUUC-Ola-086808	Oryzias latipes	72.12	3.00e-160	557.00
IUUC-Oga-088391	Otolemur garnettii	92.11	0.00e+00	708.00
IUUC-Oar-090025	Ovis aries	78.95	7.00e-165	573.00
IUUC-Ptr-090975	Pan troglodytes	91.84	0.00e+00	722.00
IUUC-Pan-092287	Papio anubis	91.84	0.00e+00	724.00
IUUC-Psi-093413	Pelodiscus sinensis	97.11	0.00e+00	749.00
IUUC-Pfo-097129	Poecilia formosa	75.95	5.00e-171	593.00
IUUC-Pab-098756	Pongo abelii	91.84	0.00e+00	722.00
IUUC-Pca-100235	Procavia capensis	81.58	0.00e+00	643.00
IUUC-Pva-102294	Pteropus vampyrus	87.89	0.00e+00	687.00
IUUC-Rno-105090	Rattus norvegicus	88.68	0.00e+00	691.00
IUUC-Sha-107521	Sarcophilus harrisii	99.47	0.00e+00	764.00
IUUC-Sar-113697	Sorex araneus	83.85	0.00e+00	642.00
IUUC-Ssc-115958	Sus scrofa	83.86	7.00e-163	565.00
IUUC-Tgu-116559	Taeniopygia guttata	95.00	0.00e+00	723.00
IUUC-Tru-117677	Takifugu rubripes	75.44	2.00e-166	578.00
IUUC-Tni-120434	Tetraodon nigroviridis	75.97	4.00e-164	570.00
IUUC-Tbe-127931	Tupaia belangeri	89.87	1.00e-174	605.00
IUUC-Ttr-128993	Tursiops truncatus	83.16	0.00e+00	634.00
IUUC-Xtr-132543	Xenopus tropicalis	87.40	0.00e+00	686.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence