iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-041315

UUCD1 version

UUC-GaA-01227

Ensembl Protein ID

ENSGACP00000021056.1

UniProt Accession

G3PTW9; G3PTW9_GASAC

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000015949.1	ENSGACT00000021090.1	ENSGACP00000021050.1
ENSGACG00000015949.1	ENSGACT00000021096.1	ENSGACP00000021056.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.00e-111	371.1	148	693

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++l+     ++   ++++k +l+ks+qkl++elw k++ ++v p++l + +k ++++f+gy+
   Q: 148  TGMKNIGNSCYMNAALQALSNCPPLTQFFLD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTSLSHGIKLVNPMFRGYA 231
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+        +        e++d +e+ d                                         
   Q: 232  QQDTQEFLRCLMDQLHEELKEpltecsmsR--------EGSDGEETRDGdrspseddflscdsgsssdrgeggaagdgepllqdtcdga 312
           *******************99555554443........4444444333355555566******************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 313  rapaggtagvgvaglisekerlkerrvsgsplhggsqemdedadvdtaaqeslperaeeeeltptasaevqspepdnevsmnqvpstpc 401
           ***************************************************************************************** PP
   S: 130  ........................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
                                                   a++kk+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pg
   Q: 402  spvrtlqelhpklssspprssplrsagpaysfkkaqlqlsARKKKQSHYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPG 490
           ****************************************99*********************************************** PP
   S: 179  keetkke.................................................slqdcLesftkeeelegenkyycekckkkqeae 218
           ke+ +k+                                                 +l+dcL++f++++el+g+n+y+ce+ckk+++ +
   Q: 491  KEDLAKLhssihqnlpvktglspdtygsqgwipfimdsirrfvvscipswfwgpmvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGV 579
           **99888********************************************************************************** PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgk 305
           k +k+ +lPe+L++hLkRf  ++e + + ki+++v+fple Ld++pf+++++ +q    +Y+L++v++H+G+++sGHYvay++n  +g+
   Q: 580  KYCKVLRLPEILCIHLKRF--RHEIMYSFKISSHVSFPLEgLDMQPFLAKESPSQ--VATYDLLSVICHHGTAGSGHYVAYCQNvINGQ 664
           *******************..9999*************************88887..9**************************78999 PP
   S: 306  WllfdDskVtevkeeevleetgstaYvlfYkr 337
           W++fdD++Vtev+e+ v++   ++aYvlfY++
   Q: 665  WYEFDDQYVTEVHETVVQN---AEAYVLFYRK 693
           *******************...********98 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

MAEQDICPHQ DSIGELTKED LLHKSKGTCQ SCGAGGPNLW ACLQSDCPYV GCGESSSDHS 60
TLHAQAEKHN LTVNLTTFRI WCYVCEREVF LEQGPAPPPA APHRRCKASE QEAAPQPVGH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCAGCCA TGGCCGAACA AGACATTTGT CCCCACCAGG ATTCCATAGG AGAGCTGACC 60
AAGGAGGACC TCCTCCACAA ATCCAAGGTT GGGTTTTCAT TCATTTACTA GAAATGTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	74.06	0.00e+00	1313.00
IUUC-Apl-003351	Anas platyrhynchos	75.38	0.00e+00	1345.00
IUUC-Ame-011777	Astyanax mexicanus	80.28	0.00e+00	1442.00
IUUC-Bta-013063	Bos taurus	74.81	0.00e+00	1330.00
IUUC-Cja-019868	Callithrix jacchus	73.89	0.00e+00	1343.00
IUUC-Cfa-020761	Canis familiaris	73.98	0.00e+00	1321.00
IUUC-Cpo-022267	Cavia porcellus	73.46	0.00e+00	1306.00
IUUC-Csa-024251	Chlorocebus sabaeus	74.43	0.00e+00	1343.00
IUUC-Cho-024483	Choloepus hoffmanni	89.15	5.00e-117	415.00
IUUC-Csv-025889	Ciona savignyi	42.77	2.00e-35	141.00
IUUC-Dre-028061	Danio rerio	71.57	0.00e+00	1276.00
IUUC-Dno-029423	Dasypus novemcinctus	74.51	0.00e+00	1336.00
IUUC-Dor-030877	Dipodomys ordii	76.17	0.00e+00	895.00
IUUC-Dme-031837	Drosophila melanogaster	49.04	9.00e-136	478.00
IUUC-Ete-032802	Echinops telfairi	62.18	7.00e-102	365.00
IUUC-Eca-034283	Equus caballus	73.17	0.00e+00	1302.00
IUUC-Eeu-034620	Erinaceus europaeus	69.40	0.00e+00	874.00
IUUC-Fca-036357	Felis catus	75.40	0.00e+00	1320.00
IUUC-Fal-037411	Ficedula albicollis	76.11	0.00e+00	1356.00
IUUC-Gga-041101	Gallus gallus	74.95	0.00e+00	1349.00
IUUC-Ggo-045600	Gorilla gorilla	74.57	0.00e+00	1313.00
IUUC-Hsa-045825	Homo sapiens	74.76	0.00e+00	1328.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	64.40	0.00e+00	1114.00
IUUC-Lch-050002	Latimeria chalumnae	71.98	0.00e+00	1258.00
IUUC-Loc-052574	Lepisosteus oculatus	81.51	0.00e+00	1453.00
IUUC-Laf-054428	Loxodonta africana	72.98	0.00e+00	1326.00
IUUC-Mcc-055736	Macaca mulatta	74.33	0.00e+00	1342.00
IUUC-Mga-059781	Meleagris gallopavo	74.44	0.00e+00	1345.00
IUUC-Mmr-061328	Microcebus murinus	83.66	0.00e+00	819.00
IUUC-Mdo-063048	Monodelphis domestica	75.13	0.00e+00	1310.00
IUUC-Mmu-064079	Mus musculus	73.89	0.00e+00	1313.00
IUUC-Mpu-066616	Mustela putorius furo	74.52	0.00e+00	1340.00
IUUC-Mlu-067294	Myotis lucifugus	74.11	0.00e+00	1302.00
IUUC-Nle-070015	Nomascus leucogenys	74.65	0.00e+00	1320.00
IUUC-Opr-070328	Ochotona princeps	73.41	0.00e+00	1327.00
IUUC-Ont-071464	Oreochromis niloticus	89.59	0.00e+00	1517.00
IUUC-Oan-073259	Ornithorhynchus anatinus	68.44	0.00e+00	1146.00
IUUC-Ocu-074630	Oryctolagus cuniculus	71.37	0.00e+00	1268.00
IUUC-Ola-087240	Oryzias latipes	86.52	0.00e+00	1470.00
IUUC-Oga-088761	Otolemur garnettii	74.17	0.00e+00	1347.00
IUUC-Oar-089490	Ovis aries	71.74	0.00e+00	1221.00
IUUC-Ptr-091662	Pan troglodytes	74.87	0.00e+00	1326.00
IUUC-Pan-092199	Papio anubis	74.17	0.00e+00	1331.00
IUUC-Psi-093726	Pelodiscus sinensis	75.57	0.00e+00	1348.00
IUUC-Pma-094389	Petromyzon marinus	62.89	1.00e-95	342.00
IUUC-Pfo-096522	Poecilia formosa	87.45	0.00e+00	1125.00
IUUC-Pab-098632	Pongo abelii	74.76	0.00e+00	1328.00
IUUC-Pca-100614	Procavia capensis	68.66	0.00e+00	1065.00
IUUC-Pva-102922	Pteropus vampyrus	66.33	0.00e+00	707.00
IUUC-Rno-105215	Rattus norvegicus	73.89	0.00e+00	1307.00
IUUC-Sce-106176	Saccharomyces cerevisiae	30.80	4.00e-26	113.00
IUUC-Sha-106601	Sarcophilus harrisii	72.94	0.00e+00	1288.00
IUUC-Ssc-115533	Sus scrofa	73.40	0.00e+00	1310.00
IUUC-Tgu-117364	Taeniopygia guttata	75.60	0.00e+00	1350.00
IUUC-Tru-117770	Takifugu rubripes	87.20	0.00e+00	1507.00
IUUC-Tni-120001	Tetraodon nigroviridis	87.22	0.00e+00	1477.00
IUUC-Ttr-128732	Tursiops truncatus	75.00	0.00e+00	1334.00
IUUC-Xtr-132157	Xenopus tropicalis	68.94	0.00e+00	1230.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence