iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134345

Ensembl Protein ID

CAG79052

UniProt Accession

Q8WZM0; Q6C789; GCN5_YARLI

Genbank Protein ID

CAC80210.1; CAG79052.1

Protein Name

Histone acetyltransferase GCN5

Genbank Nucleotide ID

AJ237940; CR382131

Gene Name

GCN5; YALI0E02772g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E02772g	CAG79052	CAG79052

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	49.00	3.00e-86	316.00	IUUC-Hsa-046970

Active Site

Position(s)	Description	Evidence
200	Proton donor/acceptor	{ECO:0000250\|UniProtKB:Q92830}

Organism

Yarrowia lipolytica

Functional Description
(View)

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).

Protein Sequence
(Fasta)

MDSDTESVKR RKSSGSESES SVRDPKRTKI EDEDFQENGI DDEDEEEEEE EAKDEGDEDD 60
EEKGEDDEED DEEKEGEDGE GEEEDEEEDE EKKREEEEKY VTSFNFDGVE YKYKERPAVI 120

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Nucleotide Sequence
(Fasta)

ATGGATTCGG ATACTGAGTC AGTGAAACGA AGAAAGTCCT CCGGGTCCGA AAGCGAGTCG 60
AGCGTGCGAG ATCCGAAACG AACCAAGATT GAAGATGAGG ATTTCCAGGA GAACGGCATA 120

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Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0012--Acyltransferase
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase

Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR000182--GNAT_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51186--GNAT

Pfam

PF00583--Acetyltransf_1
PF00439--Bromodomain

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO

Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0000775--C:chromosome, centromeric region
GO:0005829--C:cytosol
GO:0000124--C:SAGA complex
GO:0046695--C:SLIK (SAGA-like) complex
GO:0010484--F:H3 histone acetyltransferase activity
GO:0006338--P:chromatin remodeling
GO:0060358--P:negative regulation of leucine import
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0007131--P:reciprocal meiotic recombination
GO:0006351--P:transcription, DNA-templated

KEGG

yli:YALI0E02772g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001599	Ailuropoda melanoleuca	47.77	3.00e-79	287.00
IUUC-Atr-003130	Amborella trichopoda	47.26	8.00e-91	325.00
IUUC-Apl-004026	Anas platyrhynchos	47.48	1.00e-84	305.00
IUUC-Aca-005148	Anolis carolinensis	50.00	4.00e-23	102.00
IUUC-Aly-006486	Arabidopsis lyrata	44.04	7.00e-80	289.00
IUUC-Ath-006763	Arabidopsis thaliana	43.65	8.00e-80	289.00
IUUC-Ago-007819	Ashbya gossypii	77.60	0.00e+00	626.00
IUUC-Acl-008194	Aspergillus clavatus	66.38	3.00e-152	529.00
IUUC-Afl-008546	Aspergillus flavus	66.38	2.00e-153	533.00
IUUC-Afu-009124	Aspergillus fumigatus	66.67	2.00e-152	529.00
IUUC-Ani-009432	Aspergillus nidulans	66.36	2.00e-142	496.00
IUUC-Ang-009824	Aspergillus niger	66.76	5.00e-154	535.00
IUUC-Aor-010076	Aspergillus oryzae	64.90	1.00e-152	530.00
IUUC-Ame-010924	Astyanax mexicanus	46.81	7.00e-22	99.00
IUUC-Bgr-012003	Blumeria graminis	67.89	2.00e-145	506.00
IUUC-Bta-012381	Bos taurus	47.20	1.00e-83	302.00
IUUC-Bci-013974	Botrytis cinerea	63.17	7.00e-142	494.00
IUUC-Bdi-015016	Brachypodium distachyon	44.97	1.00e-90	324.00
IUUC-Bol-015982	Brassica oleracea	35.09	7.00e-07	48.50
IUUC-Bra-017875	Brassica rapa	35.09	2.00e-06	47.40
IUUC-Cel-018633	Caenorhabditis elegans	40.00	5.00e-71	260.00
IUUC-Cja-019375	Callithrix jacchus	47.77	2.00e-79	288.00
IUUC-Cfa-020400	Canis familiaris	47.77	3.00e-79	287.00
IUUC-Cpo-021686	Cavia porcellus	47.63	5.00e-85	306.00
IUUC-Cre-023019	Chlamydomonas reinhardtii	40.85	3.00e-87	313.00
IUUC-Csa-024252	Chlorocebus sabaeus	47.93	2.00e-85	308.00
IUUC-Cho-024635	Choloepus hoffmanni	58.02	6.00e-38	150.00
IUUC-Cin-025450	Ciona intestinalis	35.05	8.00e-18	82.80
IUUC-Csv-026235	Ciona savignyi	31.85	3.00e-19	85.90
IUUC-Cgl-026660	Colletotrichum gloeosporioides	68.86	6.00e-149	518.00
IUUC-Cne-027050	Cryptococcus neoformans	50.54	8.00e-101	359.00
IUUC-Dre-027468	Danio rerio	46.15	6.00e-82	296.00
IUUC-Dno-029306	Dasypus novemcinctus	47.77	3.00e-85	307.00
IUUC-Dor-030465	Dipodomys ordii	37.06	2.00e-42	165.00
IUUC-Dse-031386	Dothistroma septosporum	59.67	5.00e-127	445.00
IUUC-Dme-032140	Drosophila melanogaster	45.92	6.00e-23	102.00
IUUC-Ete-032789	Echinops telfairi	47.87	7.00e-22	99.00
IUUC-Eca-034212	Equus caballus	47.77	3.00e-79	287.00
IUUC-Eeu-034605	Erinaceus europaeus	40.06	2.00e-59	221.00
IUUC-Fca-035972	Felis catus	47.77	2.00e-85	308.00
IUUC-Fal-037223	Ficedula albicollis	48.82	3.00e-84	304.00
IUUC-Fox-037874	Fusarium oxysporum	68.99	6.00e-145	504.00
IUUC-Fso-038286	Fusarium solani	69.14	4.00e-147	512.00
IUUC-Gmo-039102	Gadus morhua	44.90	5.00e-79	286.00
IUUC-Ggr-039925	Gaeumannomyces graminis	61.41	1.00e-140	491.00
IUUC-Gga-041181	Gallus gallus	47.93	8.00e-86	309.00
IUUC-Gac-041887	Gasterosteus aculeatus	43.97	1.00e-78	285.00
IUUC-Gma-043540	Glycine max	45.66	2.00e-91	327.00
IUUC-Ggo-044607	Gorilla gorilla	47.93	1.00e-85	308.00
IUUC-Hsa-046970	Homo sapiens	47.93	2.00e-85	308.00
IUUC-Hvu-047105	Hordeum vulgare	50.53	2.00e-56	210.00
IUUC-Itr-048740	Ictidomys tridecemlineatus	47.87	5.00e-22	99.40
IUUC-Kpa-049146	Komagataella pastoris	75.75	1.00e-168	583.00
IUUC-Lch-049478	Latimeria chalumnae	46.45	5.00e-83	300.00
IUUC-Lpe-051678	Leersia perrieri	45.27	1.00e-79	288.00
IUUC-Loc-052255	Lepisosteus oculatus	45.43	1.00e-82	298.00
IUUC-Laf-054575	Loxodonta africana	47.77	3.00e-79	287.00
IUUC-Mcc-055161	Macaca mulatta	47.93	2.00e-85	308.00
IUUC-Meu-055990	Macropus eugenii	31.29	2.00e-14	73.20
IUUC-Mor-057026	Magnaporthe oryzae	62.43	3.00e-141	492.00
IUUC-Mpo-057590	Magnaporthe poae	61.58	4.00e-140	489.00
IUUC-Mtr-057835	Medicago truncatula	47.67	6.00e-89	319.00
IUUC-Mla-058950	Melampsora laricipopulina	58.06	1.00e-114	404.00
IUUC-Mga-060204	Meleagris gallopavo	48.94	1.00e-21	98.20
IUUC-Mvi-060295	Microbotryum violaceum	63.64	1.00e-133	468.00
IUUC-Mmr-060643	Microcebus murinus	46.29	1.00e-79	289.00
IUUC-Mdo-062732	Monodelphis domestica	47.77	2.00e-85	308.00
IUUC-Mmu-064125	Mus musculus	47.18	2.00e-78	285.00
IUUC-Mac-064798	Musa acuminata	34.38	4.00e-07	49.70
IUUC-Mpu-066371	Mustela putorius furo	47.93	2.00e-85	308.00
IUUC-Mlu-067447	Myotis lucifugus	46.88	8.00e-84	302.00
IUUC-Nfi-068373	Neosartorya fischeri	66.48	1.00e-154	537.00
IUUC-Ncr-068652	Neurospora crassa	67.71	2.00e-146	509.00
IUUC-Nle-069659	Nomascus leucogenys	47.93	1.00e-85	308.00
IUUC-Opr-070678	Ochotona princeps	32.35	2.00e-13	70.50
IUUC-Ont-071244	Oreochromis niloticus	46.15	4.00e-81	293.00
IUUC-Oan-072794	Ornithorhynchus anatinus	47.34	1.00e-84	305.00
IUUC-Ocu-074701	Oryctolagus cuniculus	47.77	3.00e-79	287.00
IUUC-Oba-075479	Oryza barthii	46.01	2.00e-67	248.00
IUUC-Obr-076214	Oryza brachyantha	29.33	4.00e-08	52.80
IUUC-Ogl-076970	Oryza glaberrima	44.82	3.00e-82	296.00
IUUC-Ogu-079017	Oryza glumaepatula	28.77	7.00e-08	52.00
IUUC-Oin-079610	Oryza indica	46.01	2.00e-67	248.00
IUUC-Olo-080777	Oryza longistaminata	28.77	7.00e-08	52.00
IUUC-Ome-081474	Oryza meridionalis	28.77	7.00e-08	52.00
IUUC-Oni-083016	Oryza nivara	44.75	4.00e-81	293.00
IUUC-Opu-083976	Oryza punctata	45.22	1.00e-82	298.00
IUUC-Oru-085067	Oryza rufipogon	28.77	7.00e-08	52.00
IUUC-Osa-085814	Oryza sativa	44.82	3.00e-82	296.00
IUUC-Ola-087071	Oryzias latipes	45.86	5.00e-82	296.00
IUUC-Olu-087711	Ostreococcus lucimarinus	44.00	1.00e-86	311.00
IUUC-Oga-089043	Otolemur garnettii	47.48	5.00e-79	286.00
IUUC-Oar-089893	Ovis aries	47.63	1.00e-84	305.00
IUUC-Ptr-090629	Pan troglodytes	47.93	1.00e-85	308.00
IUUC-Pan-092305	Papio anubis	47.65	5.00e-84	303.00
IUUC-Psi-093574	Pelodiscus sinensis	47.04	7.00e-82	296.00
IUUC-Pma-094160	Petromyzon marinus	45.70	1.00e-82	298.00
IUUC-Ppa-095410	Physcomitrella patens	45.56	4.00e-84	303.00
IUUC-Pfo-097043	Poecilia formosa	46.15	2.00e-81	295.00
IUUC-Pab-098748	Pongo abelii	47.93	2.00e-85	308.00
IUUC-Pop-099371	Populus trichocarpa	30.67	3.00e-06	46.60
IUUC-Pca-100223	Procavia capensis	46.75	6.00e-84	303.00
IUUC-Ppe-101832	Prunus persica	45.66	9.00e-92	328.00
IUUC-Pva-102122	Pteropus vampyrus	48.22	1.00e-79	289.00
IUUC-Pte-104228	Pyrenophora teres	62.22	3.00e-138	482.00
IUUC-Pyt-104702	Pyrenophora triticirepentis	62.22	2.00e-138	483.00
IUUC-Rno-105749	Rattus norvegicus	47.87	3.00e-22	100.00
IUUC-Sce-106432	Saccharomyces cerevisiae	77.60	0.00e+00	627.00
IUUC-Sha-107338	Sarcophilus harrisii	47.48	8.00e-85	306.00
IUUC-Spo-108273	Schizosaccharomyces pombe	60.00	3.00e-141	493.00
IUUC-Ssl-108545	Sclerotinia sclerotiorum	62.32	6.00e-135	471.00
IUUC-Smo-109385	Selaginella moellendorffii	47.56	5.00e-87	312.00
IUUC-Sit-110222	Setaria italica	45.66	6.00e-84	302.00
IUUC-Sly-111498	Solanum lycopersicum	51.20	8.00e-64	235.00
IUUC-Sar-113574	Sorex araneus	47.48	3.00e-78	284.00
IUUC-Sbi-114471	Sorghum bicolor	45.56	3.00e-84	303.00
IUUC-Sre-114915	Sporisorium reilianum	63.27	7.00e-143	498.00
IUUC-Ssc-116097	Sus scrofa	47.77	4.00e-79	286.00
IUUC-Tgu-116699	Taeniopygia guttata	47.34	8.00e-84	302.00
IUUC-Tru-118001	Takifugu rubripes	44.84	1.00e-79	288.00
IUUC-Tsy-118910	Tarsius syrichta	42.01	2.00e-67	248.00
IUUC-Tni-119684	Tetraodon nigroviridis	44.19	2.00e-79	288.00
IUUC-Tca-121066	Theobroma cacao	43.58	3.00e-88	317.00
IUUC-Tre-122112	Trichoderma reesei	67.71	4.00e-146	508.00
IUUC-Tvi-122355	Trichoderma virens	67.71	5.00e-146	508.00
IUUC-Tae-123931	Triticum aestivum	43.51	6.00e-81	292.00
IUUC-Tur-126587	Triticum urartu	43.32	3.00e-81	293.00
IUUC-Tme-126963	Tuber melanosporum	68.97	6.00e-155	538.00
IUUC-Tbe-127304	Tupaia belangeri	41.84	5.00e-67	247.00
IUUC-Ttr-128536	Tursiops truncatus	47.18	4.00e-78	283.00
IUUC-Uma-129538	Ustilago maydis	63.00	8.00e-143	498.00
IUUC-Vda-129860	Verticillium dahliae	69.52	4.00e-154	535.00
IUUC-Vpa-130239	Vicugna pacos	37.09	2.00e-50	191.00
IUUC-Vvi-130897	Vitis vinifera	45.40	1.00e-93	334.00
IUUC-Xtr-132300	Xenopus tropicalis	46.59	7.00e-84	303.00
IUUC-Xma-134105	Xiphophorus maculatus	46.29	2.00e-82	298.00
IUUC-Zma-135384	Zea mays	46.24	3.00e-85	306.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence