iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066454

Ensembl Protein ID

ENSMPUP00000003874.1

UniProt Accession

M3XXS3; M3XXS3_MUSPF

Genbank Protein ID

ENSMPUP00000003874

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01026721

Gene Name

USP28

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000003904.1	ENSMPUT00000003943.1	ENSMPUP00000003874.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-58	197.5	140	630

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 140  VGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSyslpqNVLENCPSH-TEKRNIVFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 226
           6******************************96555445555543.3678889******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            + +qqD++Ef++ lld le++++                     + +++ +k+++++++lF g++ ++ + +        +e+f +++
   Q: 227  PEEQQQDVSEFTHKLLDWLEDAFQL------------------AVNVNNPRNKSENPMVQLFYGTFLTEGVREGKPFC--NNETFGQYP 295
           799********************22..................23457899****************99998665555..5899***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e  +e    +  +   ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 296  LQVNGYR-----NLDECLEGAMVEGDIE----LLPSD--HSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 373
           *******.....99****7766666665....55544..456778899***************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 374  RYMYKskelirskrecirklkeeikvlqqkleryvkygsgparfplpdmlkyviefastkpasestasqsdahtmlplssahcpvsdla 462
           **999888888888888888888888888888888888888888888888888888877777777776666666666666666666666 PP
   S: 268  ......peekqke............................................................................ 274
                 +     e                                                                            
   Q: 463  seesssK-----Essspdvegtfsspedslpkskamnkplvssrssmempaqpaprtvtdeeinfvktclqrwrseieqdiqdlkncia 546
           6554440.....15566666666666666666777777777777788888888888888888888888888888888888899999999 PP
   S: 275  ................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                           ++ Y+L+av+vH+G+++ GHY+ay++n+ ++ Wl+++D +Vte+++ee ++++       +aY+l+Y 
   Q: 547  sttqtmeqmycdpllrQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQvWLKYNDISVTESSWEELERDSYgglrnVSAYCLMYI 630
           9999999999*****9***************************99999*******************8879************6 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MLLNQLREIT GIQDPSFLHE ALKASNGDIT QAVSLLTEER VKEPSPDTVA TEPSEGEGNT 60
ASKEALAKVI DLTHDNKDDL QAAIALSLLE SPKIQADGRD LNRMHEAASA ETKRSKRKRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNGGGC GAGGGCGGTG CGCCCGGGTG 60
GTGGGGGGCG CTAGGTCTTT GCAAGGCTCG GGCTGGGGGC GAGCTGAAGT TCTGGGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	96.01	0.00e+00	1425.00
IUUC-Apl-004010	Anas platyrhynchos	64.68	0.00e+00	1386.00
IUUC-Aca-004741	Anolis carolinensis	61.77	0.00e+00	1341.00
IUUC-Acl-008164	Aspergillus clavatus	23.56	3.00e-15	78.20
IUUC-Ang-009577	Aspergillus niger	36.36	1.00e-11	65.90
IUUC-Ate-010275	Aspergillus terreus	36.11	6.00e-12	66.60
IUUC-Ame-011910	Astyanax mexicanus	43.91	1.00e-178	621.00
IUUC-Bta-013377	Bos taurus	90.82	0.00e+00	1302.00
IUUC-Cja-019977	Callithrix jacchus	91.24	0.00e+00	1340.00
IUUC-Cfa-020378	Canis familiaris	95.81	0.00e+00	2127.00
IUUC-Cpo-021817	Cavia porcellus	86.99	0.00e+00	1286.00
IUUC-Csa-023446	Chlorocebus sabaeus	93.58	0.00e+00	2086.00
IUUC-Cho-024717	Choloepus hoffmanni	80.24	0.00e+00	672.00
IUUC-Csv-025911	Ciona savignyi	40.57	5.00e-102	365.00
IUUC-Cme-027167	Cyanidioschyzon merolae	32.49	8.00e-16	79.70
IUUC-Dre-028105	Danio rerio	57.50	0.00e+00	709.00
IUUC-Dno-029559	Dasypus novemcinctus	91.25	0.00e+00	962.00
IUUC-Dor-030955	Dipodomys ordii	86.30	0.00e+00	1280.00
IUUC-Ete-032828	Echinops telfairi	85.44	0.00e+00	804.00
IUUC-Eca-034300	Equus caballus	92.29	0.00e+00	1316.00
IUUC-Eeu-034458	Erinaceus europaeus	88.03	0.00e+00	1271.00
IUUC-Fca-035753	Felis catus	88.32	0.00e+00	1952.00
IUUC-Fal-037062	Ficedula albicollis	67.32	0.00e+00	1410.00
IUUC-Fox-037752	Fusarium oxysporum	24.88	1.00e-15	79.00
IUUC-Gga-040878	Gallus gallus	63.36	0.00e+00	889.00
IUUC-Gac-041867	Gasterosteus aculeatus	53.20	0.00e+00	1130.00
IUUC-Ggo-045384	Gorilla gorilla	91.24	0.00e+00	1344.00
IUUC-Hsa-046277	Homo sapiens	91.49	0.00e+00	1350.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	85.37	3.00e-173	602.00
IUUC-Loc-052636	Lepisosteus oculatus	63.37	0.00e+00	1371.00
IUUC-Laf-053808	Loxodonta africana	88.89	0.00e+00	1256.00
IUUC-Mcc-055473	Macaca mulatta	93.58	0.00e+00	2086.00
IUUC-Meu-056416	Macropus eugenii	67.74	0.00e+00	1402.00
IUUC-Mla-058944	Melampsora laricipopulina	22.42	3.00e-10	61.20
IUUC-Mga-060011	Meleagris gallopavo	61.86	0.00e+00	1313.00
IUUC-Mmr-060720	Microcebus murinus	86.60	0.00e+00	1245.00
IUUC-Mdo-061955	Monodelphis domestica	84.99	0.00e+00	1815.00
IUUC-Mmu-063870	Mus musculus	86.44	0.00e+00	1291.00
IUUC-Mlu-067487	Myotis lucifugus	83.67	0.00e+00	1233.00
IUUC-Nle-070044	Nomascus leucogenys	91.49	0.00e+00	1347.00
IUUC-Opr-070888	Ochotona princeps	97.11	3.00e-160	559.00
IUUC-Ont-072386	Oreochromis niloticus	57.29	0.00e+00	738.00
IUUC-Ocu-074523	Oryctolagus cuniculus	86.99	0.00e+00	1283.00
IUUC-Oga-088618	Otolemur garnettii	88.43	0.00e+00	1291.00
IUUC-Oar-089848	Ovis aries	92.25	0.00e+00	2014.00
IUUC-Ptr-091630	Pan troglodytes	90.21	0.00e+00	895.00
IUUC-Pan-092882	Papio anubis	93.12	0.00e+00	1556.00
IUUC-Psi-093422	Pelodiscus sinensis	72.61	0.00e+00	1595.00
IUUC-Pma-094250	Petromyzon marinus	51.37	1.00e-79	289.00
IUUC-Pfo-096466	Poecilia formosa	55.78	0.00e+00	750.00
IUUC-Pab-098337	Pongo abelii	91.36	0.00e+00	1344.00
IUUC-Pca-100901	Procavia capensis	69.55	0.00e+00	948.00
IUUC-Pva-102226	Pteropus vampyrus	83.19	0.00e+00	1108.00
IUUC-Rno-105735	Rattus norvegicus	89.23	0.00e+00	1999.00
IUUC-Sha-107489	Sarcophilus harrisii	79.36	0.00e+00	1737.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	35.80	6.00e-10	60.10
IUUC-Sar-112977	Sorex araneus	76.38	0.00e+00	802.00
IUUC-Ssc-115463	Sus scrofa	90.18	0.00e+00	1098.00
IUUC-Tsy-118971	Tarsius syrichta	98.39	0.00e+00	632.00
IUUC-Tni-119983	Tetraodon nigroviridis	53.54	0.00e+00	1130.00
IUUC-Ttr-128887	Tursiops truncatus	83.24	0.00e+00	1181.00
IUUC-Vpa-130614	Vicugna pacos	89.92	0.00e+00	889.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence