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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031724
UUCD1 version UUC-DrM-00146
Ensembl Protein ID FBpp0070876
UniProt Accession Q23985; A9YJA9; A9YJB1; A9YJB7; B3LF71; Q86P53; Q9W3Z1; DTX_DROME
Genbank Protein ID AAA18501.1; AAF46170.1; ACE82582.1; AAO39479.1; ABW92761.1; ABW92762.1; ABW92763.1; ABW92764.1; ABW92765.1; ABW92766.1; ABW92767.1; ABW92768.1; ABW92769.1; ABW92770.1; ABW92771.1; ABW92772.1
Protein Name Protein deltex; Probable E3 ubiquitin-protein ligase deltex; RING-type E3 ubiquitin transferase deltex
Genbank Nucleotide ID U09789; AE014298; BT033059; BT003476; EU217842; EU217843; EU217844; EU217845; EU217846; EU217847; EU217848; EU217849; EU217850; EU217851; EU217852; EU217853
Gene Name dx; CG3929
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0000524 FBtr0070914 FBpp0070876
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 41.63 3.00e-47 187.00 IUUC-Hsa-045998
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway.
 Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway.
Protein Sequence
(Fasta)
MASSAGSAAS GSVVPGGGGS AASSCATMAL STAGSGGPPV NHAHAVCVWE FESRGKWLPY 60
SPAVSQHLER AHAKKLTRVM LSDADPSLEQ YYVNVRTMTQ ESEAETAGSG LLTIGVRRMF 120
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Protein Fasta Sequence


>IUUC-Dme-031724|E3,RING|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
CATTTTCCGC TGTTGTCTCT CATTAAATCG CTGTCCAACA ATAAAAATTT CTCGCCTGCG 60
CTTGCGCTAA ATGCTAGAAA AACTGTTTTT ACCATCAAAC GTGAATTCTT AAGCTGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031724|E3,RING|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0729--SH3-binding
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50918--WWE
PS50089--ZF_RING_2
Pfam

PF02825--WWE
SMART

SM00184--RING
SM00678--WWE
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005112--F:Notch binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016348--P:imaginal disc-derived leg joint morphogenesis
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0016567--P:protein ubiquitination
GO:0008593--P:regulation of Notch signaling pathway
GO:0035220--P:wing disc development
GO:0016055--P:Wnt signaling pathway
KEGG dme:Dmel_CG3929
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001420 Ailuropoda melanoleuca 41.63 3.00e-49 188.00
IUUC-Apl-004196 Anas platyrhynchos 43.56 8.00e-50 190.00
IUUC-Aca-005007 Anolis carolinensis 42.61 1.00e-50 193.00
IUUC-Ame-011497 Astyanax mexicanus 43.23 7.00e-51 194.00
IUUC-Bta-013541 Bos taurus 43.40 1.00e-48 186.00
IUUC-Cja-019164 Callithrix jacchus 43.40 7.00e-49 187.00
IUUC-Cfa-020475 Canis familiaris 43.40 8.00e-49 187.00
IUUC-Cpo-021358 Cavia porcellus 43.40 5.00e-49 188.00
IUUC-Csa-023895 Chlorocebus sabaeus 43.40 6.00e-49 187.00
IUUC-Cho-024781 Choloepus hoffmanni 43.40 2.00e-48 185.00
IUUC-Cin-025512 Ciona intestinalis 42.65 1.00e-47 183.00
IUUC-Csv-026089 Ciona savignyi 43.09 8.00e-41 160.00
IUUC-Dre-028695 Danio rerio 42.61 4.00e-50 192.00
IUUC-Dno-029115 Dasypus novemcinctus 43.40 1.00e-48 187.00
IUUC-Dor-030701 Dipodomys ordii 43.33 4.00e-46 178.00
IUUC-Ete-033015 Echinops telfairi 42.00 5.00e-19 89.00
IUUC-Eca-033784 Equus caballus 43.40 5.00e-49 187.00
IUUC-Eeu-035106 Erinaceus europaeus 38.10 3.00e-26 112.00
IUUC-Fca-035528 Felis catus 43.40 9.00e-49 187.00
IUUC-Fal-037476 Ficedula albicollis 43.87 1.00e-48 186.00
IUUC-Gmo-039590 Gadus morhua 42.61 6.00e-49 187.00
IUUC-Gga-040162 Gallus gallus 42.79 1.00e-51 196.00
IUUC-Gac-041759 Gasterosteus aculeatus 43.04 2.00e-49 189.00
IUUC-Ggo-044787 Gorilla gorilla 43.40 8.00e-49 187.00
IUUC-Hsa-045998 Homo sapiens 43.40 8.00e-49 187.00
IUUC-Itr-048056 Ictidomys tridecemlineatus 41.63 4.00e-49 188.00
IUUC-Lch-050642 Latimeria chalumnae 44.16 8.00e-51 193.00
IUUC-Loc-052134 Lepisosteus oculatus 43.67 7.00e-51 194.00
IUUC-Laf-054482 Loxodonta africana 43.40 6.00e-49 187.00
IUUC-Mcc-055090 Macaca mulatta 43.40 4.00e-49 188.00
IUUC-Meu-056430 Macropus eugenii 43.91 1.00e-50 193.00
IUUC-Mpo-057294 Magnaporthe poae 24.05 2.90e-02 31.60
IUUC-Mga-060182 Meleagris gallopavo 42.45 3.00e-46 178.00
IUUC-Mmr-061378 Microcebus murinus 42.17 1.00e-48 187.00
IUUC-Mdo-061828 Monodelphis domestica 44.80 2.00e-50 192.00
IUUC-Mmu-063394 Mus musculus 43.40 6.00e-49 187.00
IUUC-Mpu-066276 Mustela putorius furo 43.40 1.00e-48 187.00
IUUC-Mlu-067664 Myotis lucifugus 43.40 1.00e-48 186.00
IUUC-Nle-069360 Nomascus leucogenys 43.40 8.00e-49 187.00
IUUC-Opr-070885 Ochotona princeps 42.61 3.00e-48 185.00
IUUC-Ont-072477 Oreochromis niloticus 43.04 1.00e-49 190.00
IUUC-Oan-073617 Ornithorhynchus anatinus 43.91 6.00e-51 194.00
IUUC-Ocu-074185 Oryctolagus cuniculus 43.40 1.00e-48 186.00
IUUC-Ola-086359 Oryzias latipes 45.93 3.00e-50 192.00
IUUC-Oga-088147 Otolemur garnettii 42.92 2.00e-48 186.00
IUUC-Oar-090311 Ovis aries 43.40 4.00e-49 187.00
IUUC-Ptr-091535 Pan troglodytes 43.40 8.00e-49 187.00
IUUC-Pan-092233 Papio anubis 43.40 6.00e-49 187.00
IUUC-Psi-093534 Pelodiscus sinensis 43.67 8.00e-51 192.00
IUUC-Pma-094460 Petromyzon marinus 42.06 1.00e-46 179.00
IUUC-Ppa-095323 Physcomitrella patens 40.39 8.00e-32 130.00
IUUC-Pfo-096590 Poecilia formosa 43.04 1.00e-49 191.00
IUUC-Pab-098027 Pongo abelii 43.40 7.00e-49 187.00
IUUC-Pca-100457 Procavia capensis 42.66 1.00e-28 120.00
IUUC-Pva-102574 Pteropus vampyrus 42.17 1.00e-46 180.00
IUUC-Rno-105599 Rattus norvegicus 42.92 1.00e-48 186.00
IUUC-Sha-107129 Sarcophilus harrisii 43.91 5.00e-51 194.00
IUUC-Smo-109207 Selaginella moellendorffii 38.42 1.00e-31 128.00
IUUC-Sar-113237 Sorex araneus 36.99 2.00e-31 129.00
IUUC-Ssc-116198 Sus scrofa 42.61 5.00e-48 184.00
IUUC-Tgu-116484 Taeniopygia guttata 43.87 2.00e-48 184.00
IUUC-Tru-118569 Takifugu rubripes 42.79 1.00e-50 194.00
IUUC-Tsy-119110 Tarsius syrichta 43.40 9.00e-49 187.00
IUUC-Tni-120406 Tetraodon nigroviridis 41.92 2.00e-50 192.00
IUUC-Tbe-127393 Tupaia belangeri 43.40 6.00e-49 187.00
IUUC-Ttr-128583 Tursiops truncatus 42.61 3.00e-48 185.00
IUUC-Vpa-130723 Vicugna pacos 51.55 3.00e-26 112.00
IUUC-Xtr-132217 Xenopus tropicalis 41.48 3.00e-43 169.00
Created Date 25-Jun-2017

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