iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028507

UUCD1 version

UUC-DaR-00473

Ensembl Protein ID

ENSDARP00000055536.4

UniProt Accession

Q6DEF9; Q6DEF9_DANRE

Genbank Protein ID

AAH77158.1; AAI65912.1; ABC71055.1; CAH17657.1; CAI99889.1

Protein Name

Socs1 protein; Suppressor of cytokine signaling 1; Suppressor of cytokine signalling; Suppressor of cytokine-signaling 1a

Genbank Nucleotide ID

BX470132; BC165912; DQ350479; AJ810174; AJ972922

Gene Name

socs1a; SOCS1; socs1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000038095.4	ENSDART00000055537.4	ENSDARP00000055536.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	46.79	3.00e-43	172.00	IUUC-Hsa-046010

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Protein Sequence
(Fasta)

MVAHSSVEGN QGIEDRQVST EASSDVFQSQ RSRPRQSTVA FQTHFKPFNY ARDFKIISNT 60
TSMLEESGFY WGPMTVEEAH LKLKKESVGT FLIRDSRQSD VFFTLSYKAQ NGPVSIRINF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCTGACAT TACAAAGAGC AGAAAGCAAG AGCACAGAGT TTGAGGTCGC GCTCTGAGGA 60
AACCTCTAAC GAGATATAAC GGTGGAATAA ATCAATGGGA GTTCTAAAAC GCCCGATTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0035162--P:embryonic hemopoiesis
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0060336--P:negative regulation of interferon-gamma-mediated signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0051896--P:regulation of protein kinase B signaling
GO:0042522--P:regulation of tyrosine phosphorylation of Stat5 protein
GO:0032868--P:response to insulin
GO:0060042--P:retina morphogenesis in camera-type eye

KEGG

dre:445073

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	41.03	3.00e-34	138.00
IUUC-Apl-003313	Anas platyrhynchos	47.06	2.00e-49	188.00
IUUC-Aca-005109	Anolis carolinensis	43.56	4.00e-45	174.00
IUUC-Ame-011550	Astyanax mexicanus	62.87	4.00e-68	250.00
IUUC-Bta-013411	Bos taurus	46.15	7.00e-44	170.00
IUUC-Cja-019595	Callithrix jacchus	46.79	2.00e-44	171.00
IUUC-Cfa-020563	Canis familiaris	46.79	4.00e-44	170.00
IUUC-Cpo-021374	Cavia porcellus	47.44	7.00e-45	173.00
IUUC-Csa-023333	Chlorocebus sabaeus	46.79	2.00e-44	171.00
IUUC-Dno-029406	Dasypus novemcinctus	46.79	1.00e-43	169.00
IUUC-Ete-032399	Echinops telfairi	46.79	2.00e-44	171.00
IUUC-Eca-033519	Equus caballus	45.22	2.00e-41	162.00
IUUC-Fal-036726	Ficedula albicollis	46.57	8.00e-50	189.00
IUUC-Gmo-039667	Gadus morhua	52.21	2.00e-30	125.00
IUUC-Gga-040970	Gallus gallus	47.55	1.00e-50	192.00
IUUC-Gac-041838	Gasterosteus aculeatus	47.55	2.00e-46	178.00
IUUC-Ggo-045569	Gorilla gorilla	42.93	3.00e-45	174.00
IUUC-Hsa-046010	Homo sapiens	46.79	2.00e-44	171.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	46.79	3.00e-44	171.00
IUUC-Lch-050219	Latimeria chalumnae	61.88	4.00e-56	210.00
IUUC-Loc-052494	Lepisosteus oculatus	58.00	1.00e-60	225.00
IUUC-Laf-054219	Loxodonta africana	48.85	6.00e-35	139.00
IUUC-Mcc-054830	Macaca mulatta	46.79	2.00e-44	171.00
IUUC-Meu-056565	Macropus eugenii	44.23	4.00e-46	177.00
IUUC-Mga-060153	Meleagris gallopavo	55.13	7.00e-48	183.00
IUUC-Mmr-061365	Microcebus murinus	46.79	3.00e-44	171.00
IUUC-Mdo-062824	Monodelphis domestica	43.13	3.00e-46	177.00
IUUC-Mmu-064120	Mus musculus	46.79	1.00e-44	172.00
IUUC-Mpu-066839	Mustela putorius furo	46.79	2.00e-44	171.00
IUUC-Mlu-067829	Myotis lucifugus	47.44	6.00e-45	173.00
IUUC-Nle-069592	Nomascus leucogenys	46.15	5.00e-43	167.00
IUUC-Ont-072173	Oreochromis niloticus	51.41	2.00e-47	181.00
IUUC-Ocu-073996	Oryctolagus cuniculus	46.79	2.00e-44	172.00
IUUC-Ola-087158	Oryzias latipes	48.53	7.00e-47	179.00
IUUC-Oga-088076	Otolemur garnettii	48.08	3.00e-45	174.00
IUUC-Ptr-091241	Pan troglodytes	46.79	2.00e-44	172.00
IUUC-Pan-091836	Papio anubis	43.43	3.00e-45	174.00
IUUC-Psi-093628	Pelodiscus sinensis	46.86	6.00e-48	183.00
IUUC-Pfo-097501	Poecilia formosa	53.37	4.00e-45	174.00
IUUC-Pab-098170	Pongo abelii	46.79	2.00e-44	171.00
IUUC-Pva-102796	Pteropus vampyrus	46.15	7.00e-44	170.00
IUUC-Rno-105319	Rattus norvegicus	46.79	1.00e-44	172.00
IUUC-Sha-107201	Sarcophilus harrisii	50.68	4.00e-43	166.00
IUUC-Ssc-116004	Sus scrofa	46.79	2.00e-44	171.00
IUUC-Tgu-116836	Taeniopygia guttata	48.04	7.00e-51	193.00
IUUC-Tru-118090	Takifugu rubripes	46.63	1.00e-42	166.00
IUUC-Tni-120719	Tetraodon nigroviridis	47.67	4.00e-37	147.00
IUUC-Vpa-130235	Vicugna pacos	46.79	3.00e-44	171.00
IUUC-Xtr-132610	Xenopus tropicalis	50.48	1.00e-49	189.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence