iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013330

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

F-box/LRR-repeat protein 2; F-box and leucine-rich repeat protein 2

Genbank Nucleotide ID

BC146145

Gene Name

FBXL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003952.5	ENSBTAT00000005160.5	ENSBTAP00000005160.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	95.27	0.00e+00	725.00	IUUC-Hsa-046452

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant.

Protein Sequence
(Fasta)

MVFSNNDEGL INKKLPKELL LRIFSFLDIV TLCRCAQISK AWNILALDGS NWQRIDLFNF 60
QTDVEGRVVE NISKRCGGFL RKLSLRGCIG VGDSSLKTFA QNCRNIEHLN LNGCTKITDS 120

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Nucleotide Sequence
(Fasta)

GTCGTCACCA GGACAACGGG CGTTGCCGGC GCCTTGTGAC TCTGGGCTGT GGGCGCGCTC 60
GCGGCTCTTC GGCCATGGTG AGTTTGGGGC CCTCGCAGCC CGGCCACCAG GCCCTTCCCC 120

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Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0112--Calmodulin-binding
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like
PF13516--LRR_6

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0016020--C:membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006513--P:protein monoubiquitination
GO:0016567--P:protein ubiquitination
GO:0010506--P:regulation of autophagy
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

bta:616212

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000558	Aegilops tauschii	29.30	2.00e-23	103.00
IUUC-Aml-001591	Ailuropoda melanoleuca	95.50	0.00e+00	816.00
IUUC-Atr-002443	Amborella trichopoda	31.49	2.00e-37	149.00
IUUC-Apl-004140	Anas platyrhynchos	86.79	0.00e+00	737.00
IUUC-Aly-006077	Arabidopsis lyrata	31.00	4.00e-36	146.00
IUUC-Ath-007544	Arabidopsis thaliana	29.02	7.00e-36	145.00
IUUC-Ago-007921	Ashbya gossypii	26.80	5.00e-23	103.00
IUUC-Acl-008241	Aspergillus clavatus	29.57	1.00e-40	161.00
IUUC-Afl-008737	Aspergillus flavus	29.52	2.00e-39	157.00
IUUC-Ani-009150	Aspergillus nidulans	27.32	4.00e-34	139.00
IUUC-Ang-009576	Aspergillus niger	31.13	1.00e-41	164.00
IUUC-Aor-010026	Aspergillus oryzae	29.52	2.00e-39	157.00
IUUC-Ate-010557	Aspergillus terreus	29.24	5.00e-42	166.00
IUUC-Bol-016495	Brassica oleracea	33.22	2.00e-36	147.00
IUUC-Bra-016960	Brassica rapa	31.88	2.00e-37	149.00
IUUC-Cja-019372	Callithrix jacchus	90.62	0.00e+00	739.00
IUUC-Cfa-020668	Canis familiaris	95.73	0.00e+00	817.00
IUUC-Cpo-022092	Cavia porcellus	91.71	0.00e+00	781.00
IUUC-Cre-022929	Chlamydomonas reinhardtii	28.24	7.00e-08	51.60
IUUC-Csa-023598	Chlorocebus sabaeus	95.04	0.00e+00	815.00
IUUC-Cho-024787	Choloepus hoffmanni	89.81	0.00e+00	749.00
IUUC-Cgl-026536	Colletotrichum gloeosporioides	29.77	4.00e-40	159.00
IUUC-Dno-030049	Dasypus novemcinctus	91.23	0.00e+00	777.00
IUUC-Dor-030749	Dipodomys ordii	71.53	2.00e-112	399.00
IUUC-Dse-031311	Dothistroma septosporum	28.88	2.00e-35	144.00
IUUC-Ete-033027	Echinops telfairi	82.29	0.00e+00	655.00
IUUC-Eca-033723	Equus caballus	95.97	0.00e+00	818.00
IUUC-Eeu-034930	Erinaceus europaeus	81.75	0.00e+00	679.00
IUUC-Fca-035670	Felis catus	95.73	0.00e+00	816.00
IUUC-Fal-037377	Ficedula albicollis	87.68	0.00e+00	745.00
IUUC-Gmo-038722	Gadus morhua	79.62	0.00e+00	705.00
IUUC-Gga-040836	Gallus gallus	86.49	0.00e+00	731.00
IUUC-Ggo-044534	Gorilla gorilla	95.27	0.00e+00	815.00
IUUC-Hsa-046452	Homo sapiens	95.27	0.00e+00	815.00
IUUC-Hvu-047491	Hordeum vulgare	29.09	8.00e-32	131.00
IUUC-Kpa-049356	Komagataella pastoris	31.76	1.00e-33	138.00
IUUC-Lma-052999	Leptosphaeria maculans	28.16	6.00e-38	152.00
IUUC-Laf-053965	Loxodonta africana	90.14	0.00e+00	770.00
IUUC-Mcc-055012	Macaca mulatta	95.04	0.00e+00	815.00
IUUC-Mor-057009	Magnaporthe oryzae	29.10	2.00e-32	134.00
IUUC-Mtr-057762	Medicago truncatula	31.68	2.00e-38	152.00
IUUC-Mga-059494	Meleagris gallopavo	86.08	0.00e+00	726.00
IUUC-Mmr-061409	Microcebus murinus	95.51	0.00e+00	817.00
IUUC-Mmu-063281	Mus musculus	92.20	0.00e+00	798.00
IUUC-Mpu-065900	Mustela putorius furo	95.74	0.00e+00	820.00
IUUC-Mlu-067809	Myotis lucifugus	95.02	0.00e+00	814.00
IUUC-Ncr-068681	Neurospora crassa	29.51	5.00e-30	126.00
IUUC-Nle-069953	Nomascus leucogenys	95.27	0.00e+00	815.00
IUUC-Opr-070495	Ochotona princeps	83.41	0.00e+00	702.00
IUUC-Oan-072994	Ornithorhynchus anatinus	86.73	0.00e+00	736.00
IUUC-Osa-085630	Oryza sativa	30.03	4.00e-31	129.00
IUUC-Olu-087656	Ostreococcus lucimarinus	35.35	2.00e-06	46.20
IUUC-Oga-088914	Otolemur garnettii	95.01	0.00e+00	769.00
IUUC-Oar-089424	Ovis aries	94.33	0.00e+00	717.00
IUUC-Ptr-090892	Pan troglodytes	95.27	0.00e+00	815.00
IUUC-Pan-092497	Papio anubis	95.04	0.00e+00	815.00
IUUC-Pno-095080	Phaeosphaeria nodorum	29.37	4.00e-39	156.00
IUUC-Ppa-095706	Physcomitrella patens	30.66	3.00e-35	143.00
IUUC-Pab-097772	Pongo abelii	95.27	0.00e+00	815.00
IUUC-Pca-100518	Procavia capensis	78.44	0.00e+00	632.00
IUUC-Pva-102623	Pteropus vampyrus	95.51	0.00e+00	815.00
IUUC-Pte-104289	Pyrenophora teres	28.81	7.00e-41	162.00
IUUC-Pyt-104761	Pyrenophora triticirepentis	29.06	1.00e-40	161.00
IUUC-Rno-105398	Rattus norvegicus	92.20	0.00e+00	797.00
IUUC-Smo-109569	Selaginella moellendorffii	31.03	2.00e-33	137.00
IUUC-Sit-110068	Setaria italica	30.75	4.00e-32	133.00
IUUC-Tgu-117483	Taeniopygia guttata	86.97	0.00e+00	741.00
IUUC-Tsy-119215	Tarsius syrichta	85.55	0.00e+00	719.00
IUUC-Tre-122101	Trichoderma reesei	29.17	3.00e-36	146.00
IUUC-Tvi-122616	Trichoderma virens	30.07	2.00e-39	157.00
IUUC-Tae-124451	Triticum aestivum	29.70	5.00e-33	135.00
IUUC-Tur-126305	Triticum urartu	29.70	3.00e-33	136.00
IUUC-Tbe-128062	Tupaia belangeri	91.21	0.00e+00	770.00
IUUC-Ttr-129221	Tursiops truncatus	89.34	0.00e+00	711.00
IUUC-Vda-129798	Verticillium dahliae	30.18	1.00e-36	148.00
IUUC-Vpa-130791	Vicugna pacos	89.10	0.00e+00	742.00
IUUC-Yli-134644	Yarrowia lipolytica	27.89	1.00e-30	128.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence