iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	32.7	21	65

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iC+e+f ++   p++l CgH+++++Cl+k+     ss +  rCP C
   Q: 21   CPICMESFTEEqlrPKLLHCGHTICRQCLEKL---LASSINGVRCPFC 65
           ********76667799*************888...67799999***** PP

Organism

Mus musculus

Functional Description
(View)

Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin). May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha.

Protein Sequence
(Fasta)

MAAAAAASHL NLDALREVLE CPICMESFTE EQLRPKLLHC GHTICRQCLE KLLASSINGV 60
RCPFCSKITR ITSLTQLTDN LTVLKIIDTA GLSEAVGLLM CRGCGRRLPR QFCRSCGVVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGGACGTG CTAGCGCATG CGCAGAAGGC AGCGGGCGGG TGGGCTGGCA GCGGTGGACT 60
CGCGTCGGAG CTGCGGGCGG TCAGGTAGGG GGCGGGAAGG AGGGTCTGCG ACCAGGGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR033569--TRIM32
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01436--NHL
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0042802--F:identical protein binding
GO:0017022--F:myosin binding
GO:0043621--F:protein self-association
GO:0003723--F:RNA binding
GO:0031369--F:translation initiation factor binding
GO:0043130--F:ubiquitin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007014--P:actin ubiquitination
GO:0061564--P:axon development
GO:0045444--P:fat cell differentiation
GO:0045087--P:innate immune response
GO:0046716--P:muscle cell cellular homeostasis
GO:0048147--P:negative regulation of fibroblast proliferation
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902173--P:negative regulation of keratinocyte apoptotic process
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0045787--P:positive regulation of cell cycle
GO:0030307--P:positive regulation of cell growth
GO:0030335--P:positive regulation of cell migration
GO:2000147--P:positive regulation of cell motility
GO:1903886--P:positive regulation of chemokine (C-C motif) ligand 20 production
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903883--P:positive regulation of interleukin-17-mediated signaling pathway
GO:0050769--P:positive regulation of neurogenesis
GO:0045666--P:positive regulation of neuron differentiation
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0045862--P:positive regulation of proteolysis
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051155--P:positive regulation of striated muscle cell differentiation
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0034612--P:response to tumor necrosis factor
GO:0009411--P:response to UV
GO:0001894--P:tissue homeostasis

KEGG

mmu:69807

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000568	Aegilops tauschii	36.51	3.00e-06	45.40
IUUC-Aml-001554	Ailuropoda melanoleuca	95.22	0.00e+00	1211.00
IUUC-Aca-004290	Anolis carolinensis	82.01	0.00e+00	1084.00
IUUC-Aly-006480	Arabidopsis lyrata	34.25	1.00e-08	56.60
IUUC-Ame-011474	Astyanax mexicanus	62.52	0.00e+00	832.00
IUUC-Bta-013335	Bos taurus	91.82	0.00e+00	1180.00
IUUC-Bol-015127	Brassica oleracea	34.04	2.00e-09	55.50
IUUC-Cja-019836	Callithrix jacchus	95.37	0.00e+00	1216.00
IUUC-Cfa-020126	Canis familiaris	95.68	0.00e+00	1219.00
IUUC-Cpo-021619	Cavia porcellus	95.22	0.00e+00	1214.00
IUUC-Cre-022845	Chlamydomonas reinhardtii	43.40	1.00e-05	40.80
IUUC-Csa-023381	Chlorocebus sabaeus	95.99	0.00e+00	1224.00
IUUC-Cho-024696	Choloepus hoffmanni	93.21	0.00e+00	1172.00
IUUC-Dre-028768	Danio rerio	63.01	0.00e+00	853.00
IUUC-Dno-029162	Dasypus novemcinctus	95.22	0.00e+00	1216.00
IUUC-Dor-030490	Dipodomys ordii	95.99	0.00e+00	1211.00
IUUC-Ete-032250	Echinops telfairi	91.36	0.00e+00	1149.00
IUUC-Eca-033392	Equus caballus	95.68	0.00e+00	1223.00
IUUC-Fca-035512	Felis catus	95.37	0.00e+00	1215.00
IUUC-Fal-036745	Ficedula albicollis	84.23	0.00e+00	1087.00
IUUC-Gmo-038737	Gadus morhua	60.31	0.00e+00	783.00
IUUC-Gga-040258	Gallus gallus	82.38	0.00e+00	1070.00
IUUC-Gac-041657	Gasterosteus aculeatus	60.95	0.00e+00	791.00
IUUC-Ggo-045473	Gorilla gorilla	95.68	0.00e+00	1228.00
IUUC-Hsa-046653	Homo sapiens	95.52	0.00e+00	1226.00
IUUC-Hvu-047109	Hordeum vulgare	34.92	5.00e-06	45.10
IUUC-Itr-048947	Ictidomys tridecemlineatus	96.14	0.00e+00	1226.00
IUUC-Lch-049791	Latimeria chalumnae	69.04	0.00e+00	907.00
IUUC-Loc-052573	Lepisosteus oculatus	65.12	0.00e+00	861.00
IUUC-Laf-054514	Loxodonta africana	95.06	0.00e+00	1216.00
IUUC-Mcc-055244	Macaca mulatta	95.99	0.00e+00	1224.00
IUUC-Meu-056655	Macropus eugenii	81.48	0.00e+00	1075.00
IUUC-Mtr-058731	Medicago truncatula	34.67	2.00e-10	61.20
IUUC-Mga-059343	Meleagris gallopavo	78.86	0.00e+00	996.00
IUUC-Mmr-061774	Microcebus murinus	95.52	0.00e+00	1217.00
IUUC-Mpu-066801	Mustela putorius furo	95.99	0.00e+00	1224.00
IUUC-Nle-069880	Nomascus leucogenys	95.99	0.00e+00	1223.00
IUUC-Ont-071805	Oreochromis niloticus	58.93	0.00e+00	774.00
IUUC-Oan-073221	Ornithorhynchus anatinus	81.55	0.00e+00	1031.00
IUUC-Ocu-074609	Oryctolagus cuniculus	95.37	0.00e+00	1182.00
IUUC-Olo-080692	Oryza longistaminata	38.10	7.00e-07	47.80
IUUC-Osa-086244	Oryza sativa	39.39	5.00e-08	52.00
IUUC-Oga-088597	Otolemur garnettii	96.14	0.00e+00	1224.00
IUUC-Oar-089322	Ovis aries	90.56	0.00e+00	737.00
IUUC-Ptr-091638	Pan troglodytes	95.68	0.00e+00	1228.00
IUUC-Pan-092001	Papio anubis	95.99	0.00e+00	1224.00
IUUC-Psi-093112	Pelodiscus sinensis	83.18	0.00e+00	1102.00
IUUC-Ppa-095766	Physcomitrella patens	37.35	1.00e-11	63.20
IUUC-Pfo-097226	Poecilia formosa	58.99	0.00e+00	797.00
IUUC-Pab-098115	Pongo abelii	96.14	0.00e+00	1225.00
IUUC-Rno-104950	Rattus norvegicus	98.92	0.00e+00	1258.00
IUUC-Sha-106842	Sarcophilus harrisii	83.95	0.00e+00	1083.00
IUUC-Smo-109517	Selaginella moellendorffii	38.81	3.00e-10	56.20
IUUC-Ssc-115577	Sus scrofa	95.37	0.00e+00	1215.00
IUUC-Tgu-116636	Taeniopygia guttata	83.77	0.00e+00	1084.00
IUUC-Tsy-119479	Tarsius syrichta	96.45	0.00e+00	1228.00
IUUC-Tni-120872	Tetraodon nigroviridis	56.86	0.00e+00	748.00
IUUC-Tae-124848	Triticum aestivum	36.51	4.00e-06	45.10
IUUC-Tur-126036	Triticum urartu	36.51	3.00e-06	45.40
IUUC-Ttr-129170	Tursiops truncatus	95.06	0.00e+00	1243.00
IUUC-Xtr-132839	Xenopus tropicalis	70.51	0.00e+00	941.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence