iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065773

Ensembl Protein ID

ENSMPUP00000010719.1

UniProt Accession

M3YHB2; M3YHB2_MUSPF

Genbank Protein ID

ENSMPUP00000010719

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEYP01067510

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010807.1	ENSMPUT00000010898.1	ENSMPUP00000010719.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.10e-135	449.5	589	923

Active Site

Position(s)	Description	Evidence
892	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 589  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 676
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 677  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 762
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 763  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 850
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk......prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+      p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 851  TGTCRLPLGGFAELMglgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 923
           ***********************************************************************96 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAV YTEVIVDGEI KKTAKSSSSS 60
NPKWDEQLTV HVTPQSTLEF RVWSHYTLKA DALLGRATID LKQALLIHNR KLESVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACTG CTTCACCACG GTCTGATACT AGTAATAACC ACAGTGGAAG GTTACAATTA 60
CAGGTAACTG GTAAGTTATG TTCATAATAA CTTAAAATAG TGATTCCCTG ATAAAACTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	96.32	0.00e+00	1815.00
IUUC-Apl-003310	Anas platyrhynchos	84.09	0.00e+00	1561.00
IUUC-Aca-005388	Anolis carolinensis	80.71	0.00e+00	1467.00
IUUC-Bta-012857	Bos taurus	93.40	0.00e+00	1729.00
IUUC-Cel-018299	Caenorhabditis elegans	67.13	0.00e+00	837.00
IUUC-Cja-019448	Callithrix jacchus	94.37	0.00e+00	1788.00
IUUC-Cfa-020728	Canis familiaris	96.86	0.00e+00	1809.00
IUUC-Cpo-021635	Cavia porcellus	89.09	0.00e+00	1695.00
IUUC-Csa-023805	Chlorocebus sabaeus	96.05	0.00e+00	1357.00
IUUC-Cho-024943	Choloepus hoffmanni	84.41	0.00e+00	1217.00
IUUC-Cin-025212	Ciona intestinalis	73.79	0.00e+00	907.00
IUUC-Csv-026256	Ciona savignyi	72.76	0.00e+00	900.00
IUUC-Dre-028245	Danio rerio	73.33	0.00e+00	1238.00
IUUC-Dno-029618	Dasypus novemcinctus	94.81	0.00e+00	1773.00
IUUC-Dor-030665	Dipodomys ordii	78.70	0.00e+00	1178.00
IUUC-Dme-032041	Drosophila melanogaster	69.90	0.00e+00	901.00
IUUC-Ete-032779	Echinops telfairi	94.91	0.00e+00	1117.00
IUUC-Eca-033313	Equus caballus	93.07	0.00e+00	1709.00
IUUC-Eeu-035259	Erinaceus europaeus	86.15	0.00e+00	1588.00
IUUC-Fca-035420	Felis catus	95.13	0.00e+00	1790.00
IUUC-Fal-037335	Ficedula albicollis	82.90	0.00e+00	1533.00
IUUC-Gmo-039172	Gadus morhua	86.49	0.00e+00	1050.00
IUUC-Gga-040246	Gallus gallus	83.39	0.00e+00	1545.00
IUUC-Gac-042211	Gasterosteus aculeatus	90.99	0.00e+00	1159.00
IUUC-Ggo-045001	Gorilla gorilla	94.46	0.00e+00	1582.00
IUUC-Hsa-046544	Homo sapiens	94.37	0.00e+00	1786.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	92.26	0.00e+00	1703.00
IUUC-Lch-050398	Latimeria chalumnae	77.37	0.00e+00	1395.00
IUUC-Loc-052116	Lepisosteus oculatus	75.75	0.00e+00	1383.00
IUUC-Laf-053551	Loxodonta africana	92.76	0.00e+00	1692.00
IUUC-Meu-056455	Macropus eugenii	67.98	0.00e+00	823.00
IUUC-Mga-059986	Meleagris gallopavo	83.73	0.00e+00	1564.00
IUUC-Mmr-060945	Microcebus murinus	91.89	0.00e+00	1717.00
IUUC-Mdo-063024	Monodelphis domestica	82.48	0.00e+00	1484.00
IUUC-Mmu-063202	Mus musculus	90.37	0.00e+00	1637.00
IUUC-Mlu-067373	Myotis lucifugus	96.49	0.00e+00	647.00
IUUC-Nle-069188	Nomascus leucogenys	94.91	0.00e+00	1795.00
IUUC-Opr-070965	Ochotona princeps	87.45	0.00e+00	1617.00
IUUC-Ont-072226	Oreochromis niloticus	91.22	0.00e+00	1165.00
IUUC-Oan-073497	Ornithorhynchus anatinus	86.49	0.00e+00	1563.00
IUUC-Ocu-073891	Oryctolagus cuniculus	89.19	0.00e+00	1628.00
IUUC-Ola-087438	Oryzias latipes	91.05	0.00e+00	1161.00
IUUC-Oga-087922	Otolemur garnettii	93.61	0.00e+00	1755.00
IUUC-Oar-089317	Ovis aries	92.43	0.00e+00	1701.00
IUUC-Ptr-090484	Pan troglodytes	94.37	0.00e+00	1786.00
IUUC-Pan-092117	Papio anubis	94.48	0.00e+00	1787.00
IUUC-Psi-093338	Pelodiscus sinensis	84.54	0.00e+00	1576.00
IUUC-Pma-094279	Petromyzon marinus	74.83	0.00e+00	843.00
IUUC-Pfo-096171	Poecilia formosa	91.55	0.00e+00	1167.00
IUUC-Pab-098654	Pongo abelii	93.00	0.00e+00	1301.00
IUUC-Pca-100501	Procavia capensis	74.17	0.00e+00	926.00
IUUC-Pva-102811	Pteropus vampyrus	80.19	0.00e+00	1424.00
IUUC-Rno-106125	Rattus norvegicus	90.15	0.00e+00	1650.00
IUUC-Sha-107243	Sarcophilus harrisii	85.91	0.00e+00	1568.00
IUUC-Ssc-115368	Sus scrofa	93.84	0.00e+00	1741.00
IUUC-Tgu-117079	Taeniopygia guttata	83.33	0.00e+00	1526.00
IUUC-Tru-118062	Takifugu rubripes	71.88	0.00e+00	1358.00
IUUC-Tsy-119507	Tarsius syrichta	89.07	0.00e+00	1654.00
IUUC-Tni-120151	Tetraodon nigroviridis	70.59	0.00e+00	1322.00
IUUC-Ttr-129260	Tursiops truncatus	84.74	0.00e+00	1526.00
IUUC-Vpa-130390	Vicugna pacos	83.20	0.00e+00	944.00
IUUC-Xtr-132877	Xenopus tropicalis	69.62	0.00e+00	1208.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence