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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046900
UUCD1 version UUC-HoS-00274
Ensembl Protein ID ENSP00000371502.3
UniProt Accession Q92793; D3DUC9; O00147; Q16376; Q4LE28; CBP_HUMAN
Genbank Protein ID AAC51331.2; AAC51339.1; AAC51340.1; AAC51770.1; BAE06125.1; EAW85335.1; EAW85336.1; EAW85337.1
Protein Name CREB-binding protein
Genbank Nucleotide ID U85962; U89354; U89355; U47741; AB210043; CH471112; CH471112; CH471112
Gene Name CREBBP; CBP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000005339.14 ENST00000262367.9 ENSP00000262367.5
ENSG00000005339.14 ENST00000382070.7 ENSP00000371502.3
ENSG00000005339.14 ENST00000637492.1 ENSP00000490244.1
ENSG00000005339.14 ENST00000570939.2 ENSP00000461002.2
ENSG00000005339.14 ENST00000573517.6 ENSP00000460474.2
ENSG00000005339.14 ENST00000571826.5 ENSP00000459490.1
ENSG00000005339.14 ENST00000572134.1 ENSP00000458254.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTDDrugBankGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 19805293
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
 Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).
Protein Sequence
(Fasta)
MAENLLDGPP NPKRAKLSSP GFSANDSTDF GSLFDLENDL PDELIPNGGE LGLLNSGNLV 60
PDAASKHKQL SELLRGGSGS SINPGIGNVS ASSPVQQGLG GQAQGQPNSA NMASLSAMGK 120
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Protein Fasta Sequence


>IUUC-Hsa-046900|E3,E3 activity/Other|Homo sapiens
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Nucleotide Sequence
(Fasta)
TTCTTTTTTT TTTAATTGAG GAATCAACAG CCGCCATCTT GTCGCGGACC CGACCGGGGC 60
TTCGAGCGCG ATCTACTCGG CCCCGCCGGT CCCGGGCCCC ACAACCGCCC GCGCACCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046900|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR031162--CBP_P300_HAT
IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR003101--KIX_dom
IPR009110--Nuc_rcpt_coact
IPR014744--Nuc_rcpt_coact_CREBbp
IPR010303--RING_CBP-p300
IPR000197--Znf_TAZ
IPR000433--Znf_ZZ
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51727--CBP_P300_HAT
PS50952--KIX
PS50134--ZF_TAZ
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF00439--Bromodomain
PF09030--Creb_binding
PF06001--DUF902
PF08214--HAT_KAT11
PF02172--KIX
PF02135--zf-TAZ
PF00569--ZZ
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM01250--KAT11
SM00551--ZnF_TAZ
SM00291--ZnF_ZZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000123--C:histone acetyltransferase complex
GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016407--F:acetyltransferase activity
GO:0003682--F:chromatin binding
GO:0000987--F:core promoter proximal region sequence-specific DNA binding
GO:0003684--F:damaged DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0043426--F:MRF binding
GO:0002039--F:p53 binding
GO:0034212--F:peptide N-acetyltransferase activity
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0004871--F:signal transducer activity
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0008270--F:zinc ion binding
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0044255--P:cellular lipid metabolic process
GO:0034644--P:cellular response to UV
GO:0042733--P:embryonic digit morphogenesis
GO:0016573--P:histone acetylation
GO:0042592--P:homeostatic process
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007219--P:Notch signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0032481--P:positive regulation of type I interferon production
GO:0006473--P:protein acetylation
GO:0006461--P:protein complex assembly
GO:0042981--P:regulation of apoptotic process
GO:1900034--P:regulation of cellular response to heat
GO:0008589--P:regulation of smoothened signaling pathway
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001666--P:response to hypoxia
GO:0048511--P:rhythmic process
GO:0007165--P:signal transduction
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process
KEGG hsa:1387
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001156 Aegilops tauschii 31.90 1.00e-92 335.00
IUUC-Aml-001390 Ailuropoda melanoleuca 97.76 0.00e+00 1753.00
IUUC-Apl-003917 Anas platyrhynchos 88.66 0.00e+00 1879.00
IUUC-Aca-005023 Anolis carolinensis 72.86 0.00e+00 1647.00
IUUC-Ath-007233 Arabidopsis thaliana 40.81 8.00e-76 279.00
IUUC-Bta-012732 Bos taurus 95.22 0.00e+00 1991.00
IUUC-Bdi-014481 Brachypodium distachyon 32.52 1.00e-91 332.00
IUUC-Bol-016000 Brassica oleracea 41.51 4.00e-76 280.00
IUUC-Bra-018090 Brassica rapa 41.51 3.00e-76 281.00
IUUC-Cja-019859 Callithrix jacchus 94.79 0.00e+00 1956.00
IUUC-Cfa-020117 Canis familiaris 95.88 0.00e+00 1990.00
IUUC-Cpo-021490 Cavia porcellus 88.42 0.00e+00 2249.00
IUUC-Csa-024144 Chlorocebus sabaeus 96.70 0.00e+00 1997.00
IUUC-Cin-025624 Ciona intestinalis 63.00 0.00e+00 1072.00
IUUC-Dre-027824 Danio rerio 86.02 0.00e+00 1585.00
IUUC-Dno-029638 Dasypus novemcinctus 93.06 0.00e+00 2200.00
IUUC-Dor-030279 Dipodomys ordii 89.22 0.00e+00 1874.00
IUUC-Dme-031716 Drosophila melanogaster 75.69 0.00e+00 793.00
IUUC-Ete-032742 Echinops telfairi 85.03 0.00e+00 1537.00
IUUC-Eca-034081 Equus caballus 96.46 0.00e+00 2029.00
IUUC-Eeu-035154 Erinaceus europaeus 93.07 0.00e+00 1539.00
IUUC-Fca-035657 Felis catus 96.55 0.00e+00 1881.00
IUUC-Gmo-039229 Gadus morhua 80.43 0.00e+00 1505.00
IUUC-Gga-041000 Gallus gallus 87.96 0.00e+00 1862.00
IUUC-Gac-042302 Gasterosteus aculeatus 63.46 0.00e+00 2036.00
IUUC-Ggo-044545 Gorilla gorilla 99.33 0.00e+00 2192.00
IUUC-Hvu-047619 Hordeum vulgare 31.72 8.00e-91 329.00
IUUC-Itr-048347 Ictidomys tridecemlineatus 97.61 0.00e+00 1607.00
IUUC-Loc-052536 Lepisosteus oculatus 88.99 0.00e+00 1600.00
IUUC-Laf-054354 Loxodonta africana 92.89 0.00e+00 2191.00
IUUC-Mtr-058740 Medicago truncatula 37.76 8.00e-68 253.00
IUUC-Mga-060006 Meleagris gallopavo 87.58 0.00e+00 1858.00
IUUC-Mmr-060671 Microcebus murinus 98.30 0.00e+00 2018.00
IUUC-Mdo-062089 Monodelphis domestica 91.91 0.00e+00 1935.00
IUUC-Mmu-063137 Mus musculus 95.31 0.00e+00 3545.00
IUUC-Mac-065060 Musa acuminata 33.88 2.00e-101 364.00
IUUC-Mpu-066456 Mustela putorius furo 95.98 0.00e+00 1999.00
IUUC-Mlu-067119 Myotis lucifugus 95.87 0.00e+00 1990.00
IUUC-Nle-069683 Nomascus leucogenys 99.46 0.00e+00 2179.00
IUUC-Opr-070886 Ochotona princeps 88.40 0.00e+00 1731.00
IUUC-Ont-071852 Oreochromis niloticus 86.10 0.00e+00 1551.00
IUUC-Oan-073606 Ornithorhynchus anatinus 87.37 0.00e+00 1823.00
IUUC-Oin-079283 Oryza indica 40.00 7.00e-74 273.00
IUUC-Olo-080969 Oryza longistaminata 40.00 9.00e-74 273.00
IUUC-Ola-086899 Oryzias latipes 83.67 0.00e+00 1527.00
IUUC-Oga-088968 Otolemur garnettii 96.95 0.00e+00 2006.00
IUUC-Oar-090446 Ovis aries 97.49 0.00e+00 1742.00
IUUC-Ptr-090698 Pan troglodytes 100.00 0.00e+00 2184.00
IUUC-Pma-094328 Petromyzon marinus 83.47 0.00e+00 1000.00
IUUC-Pfo-096203 Poecilia formosa 82.75 0.00e+00 1503.00
IUUC-Pab-098523 Pongo abelii 99.52 0.00e+00 2009.00
IUUC-Pca-100486 Procavia capensis 89.43 0.00e+00 1558.00
IUUC-Ppe-101498 Prunus persica 38.38 2.00e-68 254.00
IUUC-Pva-102672 Pteropus vampyrus 96.26 0.00e+00 1815.00
IUUC-Sit-110128 Setaria italica 40.11 3.00e-73 271.00
IUUC-Stu-112845 Solanum tuberosum 37.34 5.00e-65 242.00
IUUC-Sar-113479 Sorex araneus 79.41 0.00e+00 807.00
IUUC-Sbi-114827 Sorghum bicolor 40.54 2.00e-74 275.00
IUUC-Tgu-117133 Taeniopygia guttata 84.28 0.00e+00 1790.00
IUUC-Tru-118390 Takifugu rubripes 82.87 0.00e+00 1526.00
IUUC-Tsy-119388 Tarsius syrichta 83.87 0.00e+00 1656.00
IUUC-Tae-125906 Triticum aestivum 32.04 1.00e-92 335.00
IUUC-Ttr-128447 Tursiops truncatus 95.63 0.00e+00 1996.00
IUUC-Vpa-130585 Vicugna pacos 90.85 0.00e+00 1156.00
Created Date 25-Jun-2017

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