iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000015151.1	ENSORLT00000018987.1	ENSORLP00000018986.1
ENSORLG00000015151.1	ENSORLT00000018988.1	ENSORLP00000018987.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-128	428.4	421	756

Active Site

Position(s)	Description	Evidence
725	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+v+f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 421  PKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 508
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+e k+eYv+l+v+
   Q: 509  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTQETKKEYVRLYVN 593
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d+k +t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 594  WRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIHDWKGNTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 681
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+       prlf+i++ das+++lP+++TCfn++++P+Y+++++l++kLl+Aieet gF +
   Q: 682  TGSSRVPLQGFKALQvspsaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYETYDKLYDKLLTAIEETCGFAV 756
           *************************************************************************76 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

CLNPSQTRSK CVIKTVINSF PVLCAKNLAK KDFFRLPDPF AKVVVDGSGQ CHSTDTVRNT 60
LDPKWNQHYD LYIGKSDSIT ISVWNHKKIH KKQGAGFLGC VRLLSNAINR LKDTGYQRLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTTTAAATC CAAGTCAAAC AAGAAGTAAA TGTGTTATTA AAACAGTTAT AAAGTGTGTT 60
CATTAGTTGT CAAACACCAG TGTGAGAAAT TAGTTTTTGG CATTTGCTTA AGTAAAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	85.55	0.00e+00	1317.00
IUUC-Apl-003513	Anas platyrhynchos	86.14	0.00e+00	1339.00
IUUC-Aca-005358	Anolis carolinensis	85.18	0.00e+00	1320.00
IUUC-Ame-011320	Astyanax mexicanus	82.27	0.00e+00	1292.00
IUUC-Bta-013399	Bos taurus	85.36	0.00e+00	1310.00
IUUC-Cja-019355	Callithrix jacchus	84.32	0.00e+00	1311.00
IUUC-Cfa-020568	Canis familiaris	74.93	0.00e+00	1150.00
IUUC-Cpo-022200	Cavia porcellus	85.66	0.00e+00	1318.00
IUUC-Csa-024145	Chlorocebus sabaeus	73.33	0.00e+00	1141.00
IUUC-Cho-024804	Choloepus hoffmanni	93.91	1.00e-178	619.00
IUUC-Cin-025126	Ciona intestinalis	61.44	0.00e+00	918.00
IUUC-Dre-027650	Danio rerio	85.79	0.00e+00	1349.00
IUUC-Dno-029534	Dasypus novemcinctus	85.49	0.00e+00	1311.00
IUUC-Dme-031740	Drosophila melanogaster	71.00	4.00e-175	608.00
IUUC-Ete-032715	Echinops telfairi	81.28	0.00e+00	1224.00
IUUC-Eca-033580	Equus caballus	85.62	0.00e+00	1315.00
IUUC-Eeu-034945	Erinaceus europaeus	83.58	0.00e+00	1210.00
IUUC-Fca-035905	Felis catus	73.52	0.00e+00	1140.00
IUUC-Fal-037275	Ficedula albicollis	85.71	0.00e+00	1335.00
IUUC-Gmo-039486	Gadus morhua	66.79	0.00e+00	756.00
IUUC-Gga-041060	Gallus gallus	82.94	0.00e+00	1261.00
IUUC-Gac-041295	Gasterosteus aculeatus	89.96	0.00e+00	1409.00
IUUC-Ggo-045408	Gorilla gorilla	70.84	0.00e+00	1065.00
IUUC-Hsa-046726	Homo sapiens	85.62	0.00e+00	1312.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	74.97	0.00e+00	1151.00
IUUC-Lch-050026	Latimeria chalumnae	84.79	0.00e+00	1308.00
IUUC-Loc-051760	Lepisosteus oculatus	82.33	0.00e+00	1318.00
IUUC-Laf-053753	Loxodonta africana	85.75	0.00e+00	1314.00
IUUC-Mcc-054815	Macaca mulatta	85.49	0.00e+00	1310.00
IUUC-Meu-056436	Macropus eugenii	68.50	0.00e+00	1002.00
IUUC-Mga-059723	Meleagris gallopavo	73.37	0.00e+00	1134.00
IUUC-Mmr-060806	Microcebus murinus	84.63	0.00e+00	1316.00
IUUC-Mdo-062805	Monodelphis domestica	84.71	0.00e+00	1296.00
IUUC-Mmu-064034	Mus musculus	85.36	0.00e+00	1308.00
IUUC-Mpu-066762	Mustela putorius furo	85.68	0.00e+00	1321.00
IUUC-Mlu-066981	Myotis lucifugus	85.49	0.00e+00	1312.00
IUUC-Nle-069804	Nomascus leucogenys	85.62	0.00e+00	1311.00
IUUC-Opr-070591	Ochotona princeps	80.76	0.00e+00	1216.00
IUUC-Ont-071239	Oreochromis niloticus	90.48	0.00e+00	1424.00
IUUC-Oan-072699	Ornithorhynchus anatinus	82.55	0.00e+00	1306.00
IUUC-Ocu-074913	Oryctolagus cuniculus	85.62	0.00e+00	1313.00
IUUC-Oga-089116	Otolemur garnettii	82.88	0.00e+00	1261.00
IUUC-Oar-089366	Ovis aries	85.27	0.00e+00	1313.00
IUUC-Ptr-091382	Pan troglodytes	85.62	0.00e+00	1312.00
IUUC-Pan-092479	Papio anubis	75.37	0.00e+00	1160.00
IUUC-Psi-093298	Pelodiscus sinensis	86.67	0.00e+00	1316.00
IUUC-Pma-094354	Petromyzon marinus	68.96	0.00e+00	1033.00
IUUC-Pfo-096071	Poecilia formosa	88.59	0.00e+00	1407.00
IUUC-Pab-098682	Pongo abelii	85.62	0.00e+00	1311.00
IUUC-Pca-100516	Procavia capensis	84.73	2.00e-175	609.00
IUUC-Pva-102754	Pteropus vampyrus	84.42	0.00e+00	1278.00
IUUC-Rno-105396	Rattus norvegicus	73.20	0.00e+00	1139.00
IUUC-Sha-107144	Sarcophilus harrisii	83.78	0.00e+00	1193.00
IUUC-Sar-113122	Sorex araneus	75.26	0.00e+00	1102.00
IUUC-Ssc-116413	Sus scrofa	74.73	0.00e+00	1118.00
IUUC-Tgu-117112	Taeniopygia guttata	85.03	0.00e+00	1318.00
IUUC-Tru-117746	Takifugu rubripes	93.63	0.00e+00	1374.00
IUUC-Tsy-119455	Tarsius syrichta	74.48	0.00e+00	1088.00
IUUC-Tbe-127371	Tupaia belangeri	76.70	0.00e+00	1038.00
IUUC-Ttr-128423	Tursiops truncatus	74.33	0.00e+00	1105.00
IUUC-Vpa-130591	Vicugna pacos	79.29	0.00e+00	1181.00
IUUC-Xtr-132237	Xenopus tropicalis	73.09	0.00e+00	1133.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence