iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091073

Ensembl Protein ID

ENSPTRP00000041051.3

UniProt Accession

H2R0P8; H2R0P8_PANTR

Genbank Protein ID

ENSPTRP00000041051

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03089062

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000004896.5	ENSPTRT00000048192.3	ENSPTRP00000041051.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.40e-28	97.2	273	323

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 1    ekvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrsk 54
           +kvC  C+++g+d+ ++++Ce C++ +H  Clk++  eelp ++ w C+ Cr +
   Q: 273  CKVCQACRKPGNDS-KMLVCETCDKGYHTFCLKPP-MEELPAHS-WKCKACRVC 323
           57999999999987.6*******************.*******8.******965 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MDSQKLAGED KDSEPAADGP AASEDPSATE SDLPNPHVGE VSVLSSGSAR LQETPQDCSG 60
GPVRRCALCN CGEPSLHGQR ELRRFELPFD WPRCPVVSPG GSPGPNEAVL PSEDLSQIGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACAGCC AGAAGCTGGC TGGTGAGGAT AAAGATTCAG AACCGGCAGG TGAGTAGGAC 60
AAATTGTTTG TTTGCTTTTA GATTTCATTG GCAACCTTAC ATTTCTGGTC CTGGCACAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0008284--P:positive regulation of cell proliferation
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043627--P:response to estrogen

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001806	Ailuropoda melanoleuca	94.34	0.00e+00	3745.00
IUUC-Aca-005364	Anolis carolinensis	53.16	0.00e+00	1237.00
IUUC-Ame-010612	Astyanax mexicanus	79.41	0.00e+00	886.00
IUUC-Bta-013011	Bos taurus	92.70	0.00e+00	3649.00
IUUC-Cja-019841	Callithrix jacchus	95.58	0.00e+00	3872.00
IUUC-Cfa-021131	Canis familiaris	93.69	0.00e+00	3750.00
IUUC-Cpo-021957	Cavia porcellus	90.39	0.00e+00	3753.00
IUUC-Csa-023722	Chlorocebus sabaeus	97.55	0.00e+00	3868.00
IUUC-Dno-029932	Dasypus novemcinctus	85.70	0.00e+00	2257.00
IUUC-Dor-030192	Dipodomys ordii	86.69	0.00e+00	1721.00
IUUC-Ete-032572	Echinops telfairi	87.76	0.00e+00	2025.00
IUUC-Eca-034166	Equus caballus	93.07	0.00e+00	751.00
IUUC-Eeu-034848	Erinaceus europaeus	92.58	0.00e+00	1335.00
IUUC-Fca-035424	Felis catus	93.62	0.00e+00	3768.00
IUUC-Fal-037179	Ficedula albicollis	66.31	0.00e+00	1170.00
IUUC-Gga-040815	Gallus gallus	58.55	0.00e+00	1906.00
IUUC-Ggo-044711	Gorilla gorilla	98.70	0.00e+00	3910.00
IUUC-Hsa-046567	Homo sapiens	98.73	0.00e+00	3886.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	93.00	0.00e+00	3739.00
IUUC-Loc-051979	Lepisosteus oculatus	80.78	0.00e+00	929.00
IUUC-Laf-054377	Loxodonta africana	92.89	0.00e+00	3691.00
IUUC-Mcc-055577	Macaca mulatta	96.58	0.00e+00	3825.00
IUUC-Meu-055992	Macropus eugenii	84.80	0.00e+00	1323.00
IUUC-Mmr-061772	Microcebus murinus	90.87	0.00e+00	3744.00
IUUC-Mdo-062876	Monodelphis domestica	83.80	0.00e+00	1145.00
IUUC-Mmu-063903	Mus musculus	88.51	0.00e+00	3481.00
IUUC-Mpu-066700	Mustela putorius furo	94.13	0.00e+00	3717.00
IUUC-Mlu-068180	Myotis lucifugus	92.82	0.00e+00	3803.00
IUUC-Nle-069362	Nomascus leucogenys	98.27	0.00e+00	3897.00
IUUC-Opr-070304	Ochotona princeps	88.35	0.00e+00	3454.00
IUUC-Ont-071881	Oreochromis niloticus	63.00	0.00e+00	1278.00
IUUC-Oan-073663	Ornithorhynchus anatinus	86.99	0.00e+00	887.00
IUUC-Ocu-074053	Oryctolagus cuniculus	90.35	0.00e+00	3606.00
IUUC-Ome-081892	Oryza meridionalis	35.96	3.00e-13	70.50
IUUC-Ola-086384	Oryzias latipes	57.30	0.00e+00	1204.00
IUUC-Oga-088450	Otolemur garnettii	93.14	0.00e+00	3923.00
IUUC-Oar-089975	Ovis aries	92.49	0.00e+00	1888.00
IUUC-Pan-092871	Papio anubis	96.22	0.00e+00	3884.00
IUUC-Pab-097679	Pongo abelii	98.44	0.00e+00	3954.00
IUUC-Pca-100499	Procavia capensis	88.19	0.00e+00	2290.00
IUUC-Pva-102898	Pteropus vampyrus	94.42	0.00e+00	3651.00
IUUC-Rno-105660	Rattus norvegicus	88.73	0.00e+00	3598.00
IUUC-Sha-107431	Sarcophilus harrisii	82.21	0.00e+00	3121.00
IUUC-Sly-111765	Solanum lycopersicum	30.46	2.00e-23	103.00
IUUC-Sbi-113816	Sorghum bicolor	33.71	2.00e-13	71.20
IUUC-Ssc-115678	Sus scrofa	92.55	0.00e+00	3656.00
IUUC-Tsy-118905	Tarsius syrichta	88.16	0.00e+00	1687.00
IUUC-Tbe-127625	Tupaia belangeri	86.02	1.00e-157	553.00
IUUC-Ttr-129162	Tursiops truncatus	91.90	0.00e+00	2132.00
IUUC-Xtr-132455	Xenopus tropicalis	62.42	0.00e+00	1177.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence