iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oin-079097

UUCD1 version

UUC-OrI-00025

Ensembl Protein ID

BGIOSGA014597-PA

UniProt Accession

A2XW69; B8ASX7; BRE1A_ORYSI

Genbank Protein ID

EEC77758.1

Protein Name

E3 ubiquitin-protein ligase BRE1-like 1; RING-type E3 ubiquitin transferase BRE1-like 1

Genbank Nucleotide ID

CM000129

Gene Name

BRE1A; OsI_16895

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
BGIOSGA014597	BGIOSGA014597-TA	BGIOSGA014597-PA

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	42.62	0.00e+00	639.00	IUUC-Ath-007462
E3 activity/RING/RING	30.95	2.00e-17	87.80	IUUC-Cel-018659
E3 activity/RING/RING	27.79	2.00e-28	125.00	IUUC-Dme-032034
E3 activity/RING/RING	30.21	3.00e-32	137.00	IUUC-Rno-105165
E3 activity/RING/RING	25.00	6.00e-14	74.70	IUUC-Sce-106384
E3 activity/RING/RING	28.76	9.00e-18	87.00	IUUC-Spo-108304

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oryza indica

Functional Description
(View)

E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and maybe H3K79me. It thereby plays a central role in histone code and gene regulation. Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBC2/RAD6.

Protein Sequence
(Fasta)

MGSTGEPDRK RRLSSSVAPG GGAPVSPAKR LAVAPTSEDK KLDFTVLKYK NQKLSEQLEA 60
HKFEYRALEN KFAGLKEKQR THNETLSLVN SSWEQLVADL KSRSFCKSGS PNSSPGSGHN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGAGCA CGGGGGAGCC CGACCGGAAG CGGCGGCTCA GTAGCTCCGT CGCGCCCGGC 60
GGCGGGGCCC CTGTTTCTCC TGCCAAGCGG CTGGCGGTTG CACCCACCTC CGAAGATAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016049--P:cell growth
GO:0009817--P:defense response to fungus, incompatible interaction
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:0009965--P:leaf morphogenesis
GO:0010389--P:regulation of G2/M transition of mitotic cell cycle
GO:0010162--P:seed dormancy process
GO:0010228--P:vegetative to reproductive phase transition of meristem

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000994	Aegilops tauschii	53.78	0.00e+00	817.00
IUUC-Aml-002295	Ailuropoda melanoleuca	31.13	2.00e-31	130.00
IUUC-Atr-002836	Amborella trichopoda	46.31	0.00e+00	667.00
IUUC-Apl-003407	Anas platyrhynchos	28.93	1.00e-28	121.00
IUUC-Aca-004850	Anolis carolinensis	30.05	3.00e-29	123.00
IUUC-Aly-006055	Arabidopsis lyrata	42.78	4.00e-174	604.00
IUUC-Ath-007462	Arabidopsis thaliana	42.79	7.00e-178	617.00
IUUC-Ago-007988	Ashbya gossypii	33.33	4.00e-12	65.90
IUUC-Acl-008319	Aspergillus clavatus	38.46	3.00e-10	60.10
IUUC-Ang-009601	Aspergillus niger	37.93	4.00e-11	62.80
IUUC-Aor-010142	Aspergillus oryzae	36.51	1.00e-10	61.20
IUUC-Ate-010547	Aspergillus terreus	37.93	7.00e-11	62.00
IUUC-Ame-011916	Astyanax mexicanus	30.10	9.00e-29	122.00
IUUC-Bta-013173	Bos taurus	31.25	4.00e-31	129.00
IUUC-Bci-013926	Botrytis cinerea	36.21	3.00e-10	59.70
IUUC-Bdi-014799	Brachypodium distachyon	65.05	0.00e+00	991.00
IUUC-Bol-015858	Brassica oleracea	42.23	1.00e-179	623.00
IUUC-Bra-016664	Brassica rapa	42.57	2.00e-162	565.00
IUUC-Cel-018659	Caenorhabditis elegans	30.95	1.00e-18	87.80
IUUC-Cja-019042	Callithrix jacchus	31.40	3.00e-30	127.00
IUUC-Cfa-020318	Canis familiaris	31.13	3.00e-31	130.00
IUUC-Cpo-021539	Cavia porcellus	31.83	2.00e-31	130.00
IUUC-Cre-022940	Chlamydomonas reinhardtii	40.51	2.00e-12	66.60
IUUC-Csa-024051	Chlorocebus sabaeus	31.40	2.00e-31	130.00
IUUC-Cho-024616	Choloepus hoffmanni	31.33	6.00e-24	105.00
IUUC-Cin-025174	Ciona intestinalis	31.49	6.00e-29	122.00
IUUC-Csv-025830	Ciona savignyi	30.94	1.00e-24	107.00
IUUC-Cgl-026569	Colletotrichum gloeosporioides	36.84	6.00e-11	62.00
IUUC-Cne-026878	Cryptococcus neoformans	42.31	4.00e-13	69.70
IUUC-Cme-027134	Cyanidioschyzon merolae	42.42	6.00e-17	82.00
IUUC-Dre-028171	Danio rerio	29.30	9.00e-27	115.00
IUUC-Dno-028892	Dasypus novemcinctus	31.13	3.00e-31	130.00
IUUC-Dor-030268	Dipodomys ordii	31.13	3.00e-31	130.00
IUUC-Dse-031300	Dothistroma septosporum	29.53	6.00e-14	72.40
IUUC-Dme-032034	Drosophila melanogaster	27.35	5.00e-27	116.00
IUUC-Ete-033164	Echinops telfairi	28.96	1.00e-25	111.00
IUUC-Eca-033436	Equus caballus	31.13	2.00e-31	130.00
IUUC-Eeu-034801	Erinaceus europaeus	38.46	7.00e-18	85.50
IUUC-Fca-035720	Felis catus	30.83	2.00e-31	130.00
IUUC-Fal-037622	Ficedula albicollis	28.93	5.00e-25	109.00
IUUC-Fox-038017	Fusarium oxysporum	42.11	7.00e-13	68.60
IUUC-Fso-038414	Fusarium solani	26.63	1.00e-12	67.80
IUUC-Gmo-039446	Gadus morhua	28.42	3.00e-24	107.00
IUUC-Ggr-040117	Gaeumannomyces graminis	37.74	9.00e-12	64.70
IUUC-Gga-040412	Gallus gallus	28.93	2.00e-28	120.00
IUUC-Gac-041303	Gasterosteus aculeatus	30.30	3.00e-27	116.00
IUUC-Gma-042797	Glycine max	45.66	0.00e+00	679.00
IUUC-Ggo-045426	Gorilla gorilla	30.18	1.00e-31	131.00
IUUC-Hsa-045732	Homo sapiens	30.49	1.00e-31	131.00
IUUC-Hvu-047689	Hordeum vulgare	61.99	0.00e+00	1012.00
IUUC-Itr-048724	Ictidomys tridecemlineatus	31.13	3.00e-31	130.00
IUUC-Kpa-049345	Komagataella pastoris	31.07	2.00e-11	63.50
IUUC-Lch-049429	Latimeria chalumnae	29.78	3.00e-30	126.00
IUUC-Lpe-051253	Leersia perrieri	85.99	0.00e+00	1414.00
IUUC-Loc-052847	Lepisosteus oculatus	36.64	9.00e-22	96.70
IUUC-Lma-053312	Leptosphaeria maculans	30.77	4.00e-14	72.80
IUUC-Laf-054267	Loxodonta africana	31.13	3.00e-31	130.00
IUUC-Mcc-055240	Macaca mulatta	31.40	2.00e-31	130.00
IUUC-Meu-056750	Macropus eugenii	29.55	8.00e-29	122.00
IUUC-Mor-057068	Magnaporthe oryzae	40.00	5.00e-13	68.90
IUUC-Mtr-057632	Medicago truncatula	45.72	0.00e+00	695.00
IUUC-Mla-059072	Melampsora laricipopulina	42.03	1.00e-15	77.80
IUUC-Mga-059731	Meleagris gallopavo	28.93	1.00e-28	121.00
IUUC-Mvi-060341	Microbotryum violaceum	33.62	2.00e-17	84.00
IUUC-Mmr-061177	Microcebus murinus	31.40	1.00e-31	131.00
IUUC-Mdo-062415	Monodelphis domestica	30.11	3.00e-31	130.00
IUUC-Mmu-063981	Mus musculus	31.13	3.00e-31	130.00
IUUC-Mac-065103	Musa acuminata	54.07	0.00e+00	853.00
IUUC-Mpu-066498	Mustela putorius furo	30.83	3.00e-31	130.00
IUUC-Mlu-067242	Myotis lucifugus	31.13	3.00e-31	130.00
IUUC-Ncr-068695	Neurospora crassa	36.21	1.00e-12	68.20
IUUC-Nle-069058	Nomascus leucogenys	28.29	6.00e-25	108.00
IUUC-Opr-071149	Ochotona princeps	36.94	1.00e-20	95.10
IUUC-Ont-071299	Oreochromis niloticus	30.08	2.00e-27	117.00
IUUC-Oan-072996	Ornithorhynchus anatinus	28.10	3.00e-28	119.00
IUUC-Ocu-073799	Oryctolagus cuniculus	31.13	2.00e-31	130.00
IUUC-Oba-075000	Oryza barthii	95.26	0.00e+00	1590.00
IUUC-Obr-076532	Oryza brachyantha	90.72	0.00e+00	1481.00
IUUC-Ogl-077200	Oryza glaberrima	99.89	0.00e+00	1654.00
IUUC-Ogu-078279	Oryza glumaepatula	93.28	0.00e+00	1161.00
IUUC-Olo-080447	Oryza longistaminata	92.46	0.00e+00	1464.00
IUUC-Ome-081304	Oryza meridionalis	95.34	0.00e+00	1612.00
IUUC-Oni-082162	Oryza nivara	91.73	0.00e+00	1514.00
IUUC-Opu-083812	Oryza punctata	94.42	0.00e+00	1470.00
IUUC-Oru-084382	Oryza rufipogon	91.62	0.00e+00	1512.00
IUUC-Osa-085839	Oryza sativa	32.84	2.00e-69	256.00
IUUC-Ola-086435	Oryzias latipes	30.11	1.00e-27	117.00
IUUC-Olu-087683	Ostreococcus lucimarinus	46.27	3.00e-17	79.70
IUUC-Oga-089016	Otolemur garnettii	31.40	2.00e-31	130.00
IUUC-Oar-089589	Ovis aries	31.25	4.00e-31	129.00
IUUC-Ptr-091602	Pan troglodytes	28.29	6.00e-25	108.00
IUUC-Pan-092502	Papio anubis	31.40	2.00e-31	130.00
IUUC-Psi-093554	Pelodiscus sinensis	28.10	6.00e-25	108.00
IUUC-Pno-095079	Phaeosphaeria nodorum	35.23	1.00e-14	74.30
IUUC-Ppa-095651	Physcomitrella patens	32.57	3.00e-116	412.00
IUUC-Pfo-097527	Poecilia formosa	29.11	1.00e-23	104.00
IUUC-Pab-098619	Pongo abelii	31.40	1.00e-31	131.00
IUUC-Pop-099376	Populus trichocarpa	47.18	0.00e+00	695.00
IUUC-Pca-100544	Procavia capensis	31.13	2.00e-31	130.00
IUUC-Ppe-102065	Prunus persica	48.02	0.00e+00	686.00
IUUC-Pva-102479	Pteropus vampyrus	31.13	3.00e-31	129.00
IUUC-Pte-104415	Pyrenophora teres	41.27	2.00e-14	74.30
IUUC-Pyt-104762	Pyrenophora triticirepentis	41.27	2.00e-14	73.90
IUUC-Rno-105165	Rattus norvegicus	31.13	3.00e-31	129.00
IUUC-Sce-106384	Saccharomyces cerevisiae	25.00	1.00e-14	74.30
IUUC-Sha-107602	Sarcophilus harrisii	30.11	4.00e-31	129.00
IUUC-Sja-107993	Schizosaccharomyces japonicus	46.55	4.00e-13	69.30
IUUC-Spo-108304	Schizosaccharomyces pombe	27.95	4.00e-17	82.80
IUUC-Ssl-108546	Sclerotinia sclerotiorum	37.93	4.00e-11	62.40
IUUC-Smo-109550	Selaginella moellendorffii	35.49	8.00e-119	420.00
IUUC-Sit-109889	Setaria italica	71.12	0.00e+00	1162.00
IUUC-Sly-111490	Solanum lycopersicum	45.23	2.00e-178	618.00
IUUC-Sar-113349	Sorex araneus	29.44	1.00e-21	98.20
IUUC-Sbi-114734	Sorghum bicolor	75.91	2.00e-97	347.00
IUUC-Sre-115087	Sporisorium reilianum	36.36	6.00e-17	82.00
IUUC-Ssc-116134	Sus scrofa	30.58	6.00e-29	122.00
IUUC-Tgu-116549	Taeniopygia guttata	28.93	1.00e-24	108.00
IUUC-Tru-117867	Takifugu rubripes	29.27	5.00e-27	115.00
IUUC-Tsy-118808	Tarsius syrichta	28.61	1.00e-23	104.00
IUUC-Tni-120802	Tetraodon nigroviridis	29.81	1.00e-27	117.00
IUUC-Tca-121060	Theobroma cacao	47.58	0.00e+00	725.00
IUUC-Tre-122150	Trichoderma reesei	39.66	2.00e-12	67.00
IUUC-Tvi-122431	Trichoderma virens	37.93	9.00e-12	64.70
IUUC-Tae-125415	Triticum aestivum	65.16	0.00e+00	1090.00
IUUC-Tur-126786	Triticum urartu	58.84	0.00e+00	944.00
IUUC-Tme-127177	Tuber melanosporum	24.43	1.00e-11	64.30
IUUC-Tbe-127597	Tupaia belangeri	31.64	5.00e-30	125.00
IUUC-Ttr-128303	Tursiops truncatus	30.35	1.00e-29	125.00
IUUC-Uma-129488	Ustilago maydis	43.86	1.00e-16	81.30
IUUC-Vda-129815	Verticillium dahliae	36.84	1.00e-10	60.80
IUUC-Vpa-130237	Vicugna pacos	28.10	9.00e-26	111.00
IUUC-Vvi-131316	Vitis vinifera	48.59	0.00e+00	717.00
IUUC-Xtr-132906	Xenopus tropicalis	29.07	4.00e-29	122.00
IUUC-Xma-133607	Xiphophorus maculatus	29.81	4.00e-27	116.00
IUUC-Yli-134445	Yarrowia lipolytica	36.51	9.00e-12	64.70
IUUC-Zma-135805	Zea mays	68.88	0.00e+00	1085.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence