iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011320

Ensembl Protein ID

ENSAMXP00000015935.1

UniProt Accession

W5L7X3; W5L7X3_ASTMX

Genbank Protein ID

ENSAMXP00000015935

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01094989

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000015460.1	ENSAMXT00000015935.1	ENSAMXP00000015935.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-128	426.8	431	765

Active Site

Position(s)	Description	Evidence
734	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+v+f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 431  QKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 518
           689999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++led+e+vdp+l++sl +i+en   di+   ld tf+v+++ +g++ ++eLkp+G++ipV +e k+eYv+l+v+
   Q: 519  GFTLPFYKQLLGKPITLEDMESVDPDLHNSLVWILEN---DITGV-LDHTFCVEHSAYGQIIQHELKPNGKTIPVSEETKKEYVRLYVN 603
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+  gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d++++t+ k+ +t+ds++++wFw+++e f++e r+++LqFv
   Q: 604  WRFLHGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDIHDWRANTRLKH-CTADSNVVKWFWKAVETFDEERRARLLQFV 691
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+      pr f+i++ das+++lP+++TCfn+ ++P+Y+s+++l++kLl+Aieet gF +
   Q: 692  TGSSRVPLQGFKALQdlgaagPRQFTIHQiDASTNNLPKAHTCFNRVDIPPYESYDKLYDKLLTAIEETCGFAV 765
           ************************************************************************76 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MSNQGARRNG PVKLRLTVLC AKNLSKKDFF RLPDPFAKVV VDGSGQCHST DTVRNTLDPK 60
WNQHYDLYIG KLDSITISVW NHKKIHKKQG AGFLGCVRLL SNVINRLKDT GYQKLDLNRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGTATGT CTGGAAAACT GGCCCAACTC TGTTTAAAAG GGTGGATTCA ACAGACTGCA 60
GCGGTGTAGT GCGGCGCGTT GATCACGAGA GGTCGCTGGA GACGCTTTTG GGGCAGAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	87.65	0.00e+00	1362.00
IUUC-Apl-003513	Anas platyrhynchos	89.07	0.00e+00	1387.00
IUUC-Aca-005358	Anolis carolinensis	88.51	0.00e+00	1405.00
IUUC-Bta-013399	Bos taurus	87.58	0.00e+00	1358.00
IUUC-Cja-019355	Callithrix jacchus	87.80	0.00e+00	1368.00
IUUC-Cpo-022200	Cavia porcellus	88.02	0.00e+00	1363.00
IUUC-Cho-024804	Choloepus hoffmanni	92.28	1.00e-174	606.00
IUUC-Cin-025126	Ciona intestinalis	62.95	0.00e+00	944.00
IUUC-Csv-026339	Ciona savignyi	61.73	0.00e+00	975.00
IUUC-Dre-027650	Danio rerio	90.52	0.00e+00	1456.00
IUUC-Dno-029534	Dasypus novemcinctus	87.86	0.00e+00	1389.00
IUUC-Ete-032715	Echinops telfairi	83.02	0.00e+00	1275.00
IUUC-Eca-033580	Equus caballus	88.02	0.00e+00	1363.00
IUUC-Eeu-034945	Erinaceus europaeus	86.57	0.00e+00	1268.00
IUUC-Fal-037275	Ficedula albicollis	87.02	0.00e+00	1375.00
IUUC-Gga-041060	Gallus gallus	85.38	0.00e+00	1345.00
IUUC-Gac-041983	Gasterosteus aculeatus	88.28	0.00e+00	1399.00
IUUC-Hsa-046726	Homo sapiens	87.86	0.00e+00	1389.00
IUUC-Lch-050026	Latimeria chalumnae	87.99	0.00e+00	1399.00
IUUC-Loc-051760	Lepisosteus oculatus	87.14	0.00e+00	1378.00
IUUC-Laf-053753	Loxodonta africana	88.13	0.00e+00	1362.00
IUUC-Mcc-054815	Macaca mulatta	87.73	0.00e+00	1387.00
IUUC-Meu-056436	Macropus eugenii	67.40	0.00e+00	1003.00
IUUC-Mmr-060806	Microcebus murinus	87.75	0.00e+00	1362.00
IUUC-Mdo-062805	Monodelphis domestica	86.95	0.00e+00	1376.00
IUUC-Mmu-064034	Mus musculus	87.99	0.00e+00	1390.00
IUUC-Mpu-066762	Mustela putorius furo	87.65	0.00e+00	1362.00
IUUC-Mlu-066981	Myotis lucifugus	87.87	0.00e+00	1360.00
IUUC-Nle-069804	Nomascus leucogenys	87.93	0.00e+00	1384.00
IUUC-Opr-070591	Ochotona princeps	83.42	0.00e+00	1271.00
IUUC-Ont-072243	Oreochromis niloticus	89.88	0.00e+00	1441.00
IUUC-Oan-072699	Ornithorhynchus anatinus	88.27	0.00e+00	1402.00
IUUC-Ocu-074913	Oryctolagus cuniculus	87.99	0.00e+00	1390.00
IUUC-Ola-086597	Oryzias latipes	82.27	0.00e+00	1263.00
IUUC-Oga-089116	Otolemur garnettii	85.07	0.00e+00	1306.00
IUUC-Oar-089366	Ovis aries	87.35	0.00e+00	1358.00
IUUC-Ptr-091382	Pan troglodytes	87.86	0.00e+00	1389.00
IUUC-Psi-093298	Pelodiscus sinensis	87.87	0.00e+00	1367.00
IUUC-Pma-094354	Petromyzon marinus	70.86	0.00e+00	1097.00
IUUC-Pfo-096071	Poecilia formosa	89.58	0.00e+00	1418.00
IUUC-Pab-098682	Pongo abelii	87.86	0.00e+00	1388.00
IUUC-Pca-100516	Procavia capensis	83.24	4.00e-171	595.00
IUUC-Pva-102754	Pteropus vampyrus	86.76	0.00e+00	1324.00
IUUC-Rno-105600	Rattus norvegicus	87.16	0.00e+00	1171.00
IUUC-Sha-107144	Sarcophilus harrisii	86.55	0.00e+00	1244.00
IUUC-Sar-113122	Sorex araneus	77.54	0.00e+00	1152.00
IUUC-Tgu-117112	Taeniopygia guttata	87.86	0.00e+00	1400.00
IUUC-Tru-118497	Takifugu rubripes	88.70	0.00e+00	1382.00
IUUC-Tni-120781	Tetraodon nigroviridis	87.67	0.00e+00	1183.00
IUUC-Tme-126897	Tuber melanosporum	38.08	7.00e-148	517.00
IUUC-Tbe-127371	Tupaia belangeri	79.46	0.00e+00	1118.00
IUUC-Ttr-129305	Tursiops truncatus	81.54	0.00e+00	1169.00
IUUC-Vpa-130591	Vicugna pacos	78.74	0.00e+00	1174.00
IUUC-Xtr-132979	Xenopus tropicalis	71.45	0.00e+00	1050.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence