iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107144

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01164147

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000011788.1	ENSSHAT00000013901.1	ENSSHAP00000013787.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-130	433.4	348	680

Active Site

Position(s)	Description	Evidence
649	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 348  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 435
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++i+Vt++Nk+eYv+l+v+
   Q: 436  GFTLPFYKQLLGKSINLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSISVTEDNKKEYVRLYVN 520
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip+ ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 521  WRFLRGIEAQFLALQKGFNEVIPQPLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNIVKWFWKAVELFDEERRARLLQFV 608
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 609  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 680
           **********************************************************************76 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

YIGKSDSVTI SVWNHKKIHK KQGAGFLGCV RLLSNAINRL KDTGYQRLDL CKLGPNDNET 60
VRGQIVVSLQ SRDRIGTGGQ VVDCSRLFDN DLPDGWEERR TASGRIQYLN HITRTTQWER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNGGAACGGG CCCGTCAAGC TGCGCCTGAC AGGTGAGGGA GGACCGCGCG ACTGGGGGGA 60
ACATGGCCAG ACTTGGGACG GGCCGGGCCC GGCTGGGCAG AAGAGGCCGC GATGTTCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	97.36	0.00e+00	1357.00
IUUC-Apl-003513	Anas platyrhynchos	96.49	0.00e+00	1352.00
IUUC-Aca-005358	Anolis carolinensis	96.51	0.00e+00	1350.00
IUUC-Ame-011320	Astyanax mexicanus	86.55	0.00e+00	1244.00
IUUC-Bta-013399	Bos taurus	97.06	0.00e+00	1352.00
IUUC-Cja-019355	Callithrix jacchus	97.21	0.00e+00	1355.00
IUUC-Cpo-022200	Cavia porcellus	97.50	0.00e+00	1361.00
IUUC-Cho-024804	Choloepus hoffmanni	97.73	0.00e+00	632.00
IUUC-Dre-027650	Danio rerio	89.68	0.00e+00	1287.00
IUUC-Dno-029534	Dasypus novemcinctus	97.06	0.00e+00	1355.00
IUUC-Ete-032715	Echinops telfairi	91.92	0.00e+00	1269.00
IUUC-Eca-033580	Equus caballus	97.36	0.00e+00	1358.00
IUUC-Eeu-034945	Erinaceus europaeus	95.99	0.00e+00	1277.00
IUUC-Fal-037275	Ficedula albicollis	96.36	0.00e+00	1342.00
IUUC-Gga-041060	Gallus gallus	92.86	0.00e+00	1276.00
IUUC-Gac-041295	Gasterosteus aculeatus	90.99	0.00e+00	1279.00
IUUC-Hsa-046726	Homo sapiens	97.36	0.00e+00	1355.00
IUUC-Itr-048042	Ictidomys tridecemlineatus	97.24	0.00e+00	1003.00
IUUC-Lch-050026	Latimeria chalumnae	94.32	0.00e+00	1313.00
IUUC-Loc-051760	Lepisosteus oculatus	86.93	0.00e+00	1261.00
IUUC-Laf-053753	Loxodonta africana	97.21	0.00e+00	1358.00
IUUC-Mcc-054815	Macaca mulatta	97.06	0.00e+00	1352.00
IUUC-Meu-056436	Macropus eugenii	80.97	0.00e+00	1083.00
IUUC-Mmr-060806	Microcebus murinus	97.36	0.00e+00	1359.00
IUUC-Mdo-062805	Monodelphis domestica	99.12	0.00e+00	1377.00
IUUC-Mmu-064034	Mus musculus	97.36	0.00e+00	1357.00
IUUC-Mpu-066762	Mustela putorius furo	97.36	0.00e+00	1357.00
IUUC-Mlu-066981	Myotis lucifugus	97.21	0.00e+00	1357.00
IUUC-Nle-069804	Nomascus leucogenys	97.36	0.00e+00	1355.00
IUUC-Opr-070591	Ochotona princeps	91.48	0.00e+00	1264.00
IUUC-Ont-071239	Oreochromis niloticus	92.30	0.00e+00	1294.00
IUUC-Oan-072699	Ornithorhynchus anatinus	94.45	0.00e+00	1342.00
IUUC-Ocu-074913	Oryctolagus cuniculus	97.36	0.00e+00	1357.00
IUUC-Ola-086597	Oryzias latipes	83.78	0.00e+00	1166.00
IUUC-Oga-089116	Otolemur garnettii	93.54	0.00e+00	1296.00
IUUC-Oar-089366	Ovis aries	97.06	0.00e+00	1353.00
IUUC-Ptr-091382	Pan troglodytes	97.36	0.00e+00	1355.00
IUUC-Psi-093298	Pelodiscus sinensis	96.78	0.00e+00	1338.00
IUUC-Pma-094354	Petromyzon marinus	72.36	0.00e+00	1004.00
IUUC-Pfo-096071	Poecilia formosa	88.49	0.00e+00	1276.00
IUUC-Pab-098682	Pongo abelii	97.36	0.00e+00	1356.00
IUUC-Pca-100516	Procavia capensis	88.95	1.00e-180	626.00
IUUC-Pva-102754	Pteropus vampyrus	96.04	0.00e+00	1323.00
IUUC-Rno-105600	Rattus norvegicus	97.17	0.00e+00	1264.00
IUUC-Sar-113122	Sorex araneus	90.60	0.00e+00	1238.00
IUUC-Tgu-117112	Taeniopygia guttata	95.92	0.00e+00	1340.00
IUUC-Tru-118497	Takifugu rubripes	88.79	0.00e+00	1239.00
IUUC-Tsy-118819	Tarsius syrichta	96.50	0.00e+00	1013.00
IUUC-Tni-120781	Tetraodon nigroviridis	89.30	0.00e+00	1174.00
IUUC-Tbe-127371	Tupaia belangeri	92.46	0.00e+00	1160.00
IUUC-Ttr-129305	Tursiops truncatus	88.89	0.00e+00	1152.00
IUUC-Vpa-130591	Vicugna pacos	86.34	0.00e+00	1168.00
IUUC-Xtr-132979	Xenopus tropicalis	74.86	0.00e+00	985.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence