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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046878
UUCD1 version UUC-HoS-00849
Ensembl Protein ID ENSP00000315454.4
UniProt Accession Q12830; Q6NX67; Q7Z7D6; Q9UIG2; BPTF_HUMAN
Genbank Protein ID BAA89208.1; AAA97522.1; AAP22284.1; AAH67234.1
Protein Name Nucleosome-remodeling factor subunit BPTF; Bromodomain and PHD finger-containing transcription factor; Fetal Alz-50 clone 1 protein; Fetal Alzheimer antigen
Genbank Nucleotide ID AB032251; AC006534; AY282495; BC067234
Gene Name BPTF; FAC1; FALZ
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000171634.16 ENST00000544778.6 ENSP00000440854.2
ENSG00000171634.16 ENST00000306378.10 ENSP00000307208.6
ENSG00000171634.16 ENST00000424123.7 ENSP00000388405.3
ENSG00000171634.16 ENST00000544491.2 ENSP00000443949.2
ENSG00000171634.16 ENST00000582467.1 ENSP00000463776.1
ENSG00000171634.16 ENST00000580465.5 ENSP00000462535.1
ENSG00000171634.16 ENST00000342579.7 ENSP00000343837.3
ENSG00000171634.16 ENST00000581258.5 ENSP00000463845.1
ENSG00000171634.16 ENST00000583990.1 ENSP00000463736.1
ENSG00000171634.16 ENST00000577837.1 ENSP00000462703.1
ENSG00000171634.16 ENST00000335221.9 ENSP00000334351.6
ENSG00000171634.16 ENST00000321892.8 ENSP00000315454.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.10e-14 55.1 2869 2917
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           +C +C+ +++++k  + C++C++w+H +C+++  ++e +  +++ Cp+C+s
   Q: 2869 YC-ICKTPYDESKFYIGCDRCQNWYHGRCVGIL-QSEAELIDEYVCPQCQS 2917
           8*.*****************************9.888888888******87 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with MAZ. Interacts with KEAP1. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with histone H3K4me3 and to a lesser extent with histone H3-K4Me2.
 Interacts with MAZ. Interacts with KEAP1. Part of the nucleosome-remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with histone H3K4me3 and to a lesser extent with histone H3-K4Me2.
Protein Sequence
(Fasta)
MRGRRGRPPK QPAAPAAERC APAPPPPPPP PTSGPIGGLR SRHRGSSRGR WAAAQAEVAP 60
KTRLSSPRGG SSSRRKPPPP PPAPPSTSAP GRGGRGGGGG RTGGGGGGGH LARTTAARRA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046878|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACAAGATG GCGGCTGAAG GCGATCCGGA GTGGGGCCCC AGCAATTCGG ATTGAGCCTT 60
CTCCCTCCAC CCGCTTCCGT CGGCCGGGCC CCTCCCGCCC GGCCCCGCGG GCCTCCCCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046878|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00439--Bromodomain
PF02791--DDT
PF00628--PHD
PF15612--WHIM1
PF15613--WSD
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD
Gene Ontology

GO:0044297--C:cell body
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016589--C:NURF complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0043565--F:sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0007420--P:brain development
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0006338--P:chromatin remodeling
GO:0016569--P:covalent chromatin modification
GO:0001892--P:embryonic placenta development
GO:0007492--P:endoderm development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009611--P:response to wounding
GO:0006351--P:transcription, DNA-templated
KEGG hsa:2186
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000221 Aegilops tauschii 29.34 9.00e-12 67.00
IUUC-Aml-001431 Ailuropoda melanoleuca 91.16 0.00e+00 3679.00
IUUC-Apl-003251 Anas platyrhynchos 65.21 0.00e+00 1443.00
IUUC-Aca-005148 Anolis carolinensis 71.62 0.00e+00 742.00
IUUC-Ame-011093 Astyanax mexicanus 65.70 4.00e-152 534.00
IUUC-Bta-012701 Bos taurus 89.34 0.00e+00 3455.00
IUUC-Bol-015269 Brassica oleracea 27.80 1.00e-18 90.10
IUUC-Bra-018092 Brassica rapa 27.34 4.00e-18 88.20
IUUC-Cel-018283 Caenorhabditis elegans 34.32 3.00e-54 208.00
IUUC-Cja-018809 Callithrix jacchus 95.96 0.00e+00 779.00
IUUC-Cfa-021079 Canis familiaris 91.38 0.00e+00 4129.00
IUUC-Cpo-021892 Cavia porcellus 84.96 0.00e+00 2120.00
IUUC-Csa-023142 Chlorocebus sabaeus 94.90 0.00e+00 3750.00
IUUC-Cho-024758 Choloepus hoffmanni 78.93 0.00e+00 1228.00
IUUC-Cin-025225 Ciona intestinalis 52.85 1.00e-41 165.00
IUUC-Csv-026235 Ciona savignyi 50.29 4.00e-56 211.00
IUUC-Dre-028054 Danio rerio 76.25 1.00e-175 612.00
IUUC-Dno-029508 Dasypus novemcinctus 80.73 0.00e+00 1856.00
IUUC-Dor-030950 Dipodomys ordii 71.57 0.00e+00 874.00
IUUC-Dme-032140 Drosophila melanogaster 52.21 1.00e-104 375.00
IUUC-Ete-032789 Echinops telfairi 77.64 0.00e+00 2041.00
IUUC-Eca-033972 Equus caballus 89.86 0.00e+00 3435.00
IUUC-Eeu-034541 Erinaceus europaeus 75.64 0.00e+00 1228.00
IUUC-Fca-036272 Felis catus 89.63 0.00e+00 2705.00
IUUC-Fal-037141 Ficedula albicollis 68.02 0.00e+00 2228.00
IUUC-Gmo-039453 Gadus morhua 77.99 2.00e-172 601.00
IUUC-Gga-040833 Gallus gallus 63.34 0.00e+00 2264.00
IUUC-Gac-042513 Gasterosteus aculeatus 74.69 0.00e+00 671.00
IUUC-Ggo-045377 Gorilla gorilla 95.82 0.00e+00 1361.00
IUUC-Hvu-047760 Hordeum vulgare 25.46 1.00e-17 86.30
IUUC-Itr-048740 Ictidomys tridecemlineatus 85.80 0.00e+00 2242.00
IUUC-Lch-049744 Latimeria chalumnae 60.29 0.00e+00 1988.00
IUUC-Loc-052694 Lepisosteus oculatus 51.31 0.00e+00 1223.00
IUUC-Laf-054223 Loxodonta africana 89.50 0.00e+00 3299.00
IUUC-Mcc-054601 Macaca mulatta 97.37 0.00e+00 4347.00
IUUC-Mtr-058758 Medicago truncatula 26.54 3.00e-22 101.00
IUUC-Mga-060204 Meleagris gallopavo 63.69 0.00e+00 2053.00
IUUC-Mmr-061332 Microcebus murinus 90.79 0.00e+00 2464.00
IUUC-Mdo-062245 Monodelphis domestica 72.00 0.00e+00 2669.00
IUUC-Mmu-063744 Mus musculus 78.99 0.00e+00 3578.00
IUUC-Mac-065252 Musa acuminata 24.82 1.00e-18 90.10
IUUC-Mpu-066289 Mustela putorius furo 88.25 0.00e+00 3390.00
IUUC-Mlu-066991 Myotis lucifugus 89.74 0.00e+00 3409.00
IUUC-Nle-070095 Nomascus leucogenys 97.81 0.00e+00 3734.00
IUUC-Ont-071778 Oreochromis niloticus 79.89 0.00e+00 665.00
IUUC-Oan-073261 Ornithorhynchus anatinus 68.91 0.00e+00 2478.00
IUUC-Ocu-074848 Oryctolagus cuniculus 87.33 0.00e+00 4025.00
IUUC-Ogu-078676 Oryza glumaepatula 22.53 1.00e-18 89.70
IUUC-Olo-080881 Oryza longistaminata 26.25 1.00e-16 83.20
IUUC-Ome-081742 Oryza meridionalis 26.10 4.00e-17 85.10
IUUC-Oru-084745 Oryza rufipogon 22.53 1.00e-18 90.10
IUUC-Ola-086685 Oryzias latipes 76.06 0.00e+00 645.00
IUUC-Oga-088994 Otolemur garnettii 90.42 0.00e+00 3403.00
IUUC-Oar-090271 Ovis aries 89.52 0.00e+00 3415.00
IUUC-Ptr-090821 Pan troglodytes 99.09 0.00e+00 4477.00
IUUC-Pan-092346 Papio anubis 86.85 1.00e-134 474.00
IUUC-Psi-093425 Pelodiscus sinensis 68.00 0.00e+00 2598.00
IUUC-Pma-094355 Petromyzon marinus 63.32 3.00e-153 537.00
IUUC-Pno-094853 Phaeosphaeria nodorum 41.10 2.00e-16 81.30
IUUC-Pfo-096995 Poecilia formosa 78.17 0.00e+00 631.00
IUUC-Pab-098056 Pongo abelii 96.34 0.00e+00 3772.00
IUUC-Pop-099219 Populus trichocarpa 29.17 4.00e-15 78.20
IUUC-Pca-100922 Procavia capensis 83.61 0.00e+00 2288.00
IUUC-Pva-103167 Pteropus vampyrus 87.67 0.00e+00 2333.00
IUUC-Pgr-103292 Puccinia graminis 51.79 8.00e-15 75.10
IUUC-Ptt-104009 Puccinia triticina 42.50 1.00e-16 80.90
IUUC-Rno-105749 Rattus norvegicus 76.94 0.00e+00 2897.00
IUUC-Sha-106874 Sarcophilus harrisii 72.02 0.00e+00 2575.00
IUUC-Sly-111813 Solanum lycopersicum 28.22 2.00e-12 68.90
IUUC-Stu-111932 Solanum tuberosum 50.00 4.00e-10 58.50
IUUC-Sar-113725 Sorex araneus 85.13 0.00e+00 813.00
IUUC-Tgu-117339 Taeniopygia guttata 94.97 2.00e-110 394.00
IUUC-Tru-118620 Takifugu rubripes 78.84 0.00e+00 631.00
IUUC-Tni-120313 Tetraodon nigroviridis 55.02 0.00e+00 1043.00
IUUC-Tbe-127684 Tupaia belangeri 82.46 0.00e+00 1635.00
IUUC-Ttr-128434 Tursiops truncatus 81.86 0.00e+00 2268.00
IUUC-Vpa-130338 Vicugna pacos 83.92 0.00e+00 1195.00
IUUC-Xtr-132434 Xenopus tropicalis 58.83 0.00e+00 1162.00
Created Date 25-Jun-2017

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