iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132624

Ensembl Protein ID

ENSXETP00000038015.3

UniProt Accession

F7BWF4; F7BWF4_XENTR

Genbank Protein ID

ENSXETP00000038015

Protein Name

Rac/Cdc42 guanine nucleotide exchange factor 6

Genbank Nucleotide ID

AAMC01014458

Gene Name

arhgef6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000017497.3	ENSXETT00000038015.3	ENSXETP00000038015.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.70e-15	55.8	165	218

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v++ ++++ qn+deL++ kGd+++v     +d+gW++g  +l+gk+G fP+n+v++ 
   Q: 165  VVKARFNFNQQNEDELSFCKGDTIYVS--RVEDGGWWEG--TLNGKSGWFPSNYVKEF 218
           68999*********************7..999*******..8*************986 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MNPEEQTVTW LISLGVLSSP KKNICNPADF LKCSLKDGVV LCKLMNRLLP GFVSKVCTEP 60
KSEEDCIENI KEFLKACSAL RVELFDPVDL YTGENFSKVL STLSAVNRAT ENPTSGRPCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACCCTG AGGAACAGAC CGTCACTTGG CTGATCTCAC TGGGGGTGTT AAGTTCTCCC 60
AAGAAAAACA TATGCAATCC TGCTGACTTC TTGAAATGTT CACTGAAGGA TGGGGTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001631	Ailuropoda melanoleuca	61.76	0.00e+00	962.00
IUUC-Atr-002848	Amborella trichopoda	33.33	6.70e+00	25.00
IUUC-Apl-003960	Anas platyrhynchos	72.14	0.00e+00	1067.00
IUUC-Aca-004988	Anolis carolinensis	70.50	0.00e+00	1031.00
IUUC-Ame-011546	Astyanax mexicanus	64.40	0.00e+00	945.00
IUUC-Bta-013527	Bos taurus	70.30	0.00e+00	1050.00
IUUC-Cja-018935	Callithrix jacchus	71.06	0.00e+00	1039.00
IUUC-Cfa-021269	Canis familiaris	69.91	0.00e+00	1029.00
IUUC-Cpo-021620	Cavia porcellus	68.01	0.00e+00	982.00
IUUC-Csa-023415	Chlorocebus sabaeus	71.08	0.00e+00	1043.00
IUUC-Dre-028580	Danio rerio	63.52	0.00e+00	964.00
IUUC-Dno-029201	Dasypus novemcinctus	67.01	0.00e+00	1007.00
IUUC-Dor-030868	Dipodomys ordii	58.44	0.00e+00	775.00
IUUC-Eca-033500	Equus caballus	70.43	0.00e+00	1026.00
IUUC-Eeu-035269	Erinaceus europaeus	63.14	2.00e-124	439.00
IUUC-Fca-035683	Felis catus	69.52	0.00e+00	1006.00
IUUC-Fal-037611	Ficedula albicollis	71.61	0.00e+00	1063.00
IUUC-Gmo-038980	Gadus morhua	61.19	0.00e+00	909.00
IUUC-Gga-040940	Gallus gallus	71.09	0.00e+00	1055.00
IUUC-Gac-042203	Gasterosteus aculeatus	60.67	0.00e+00	936.00
IUUC-Ggo-044755	Gorilla gorilla	70.95	0.00e+00	1039.00
IUUC-Hsa-046210	Homo sapiens	70.82	0.00e+00	1037.00
IUUC-Lch-049517	Latimeria chalumnae	68.81	0.00e+00	1021.00
IUUC-Loc-052393	Lepisosteus oculatus	64.80	0.00e+00	1003.00
IUUC-Laf-054196	Loxodonta africana	70.17	0.00e+00	1003.00
IUUC-Mcc-055716	Macaca mulatta	70.95	0.00e+00	1040.00
IUUC-Meu-056285	Macropus eugenii	65.01	2.00e-174	605.00
IUUC-Mtr-058576	Medicago truncatula	42.31	5.00e-12	65.10
IUUC-Mga-060029	Meleagris gallopavo	71.88	0.00e+00	1073.00
IUUC-Mmr-060803	Microcebus murinus	70.95	0.00e+00	1023.00
IUUC-Mdo-062654	Monodelphis domestica	70.47	0.00e+00	1066.00
IUUC-Mmu-063479	Mus musculus	68.96	0.00e+00	1000.00
IUUC-Mpu-066065	Mustela putorius furo	69.26	0.00e+00	997.00
IUUC-Mlu-068222	Myotis lucifugus	69.04	0.00e+00	996.00
IUUC-Nle-069379	Nomascus leucogenys	70.95	0.00e+00	1038.00
IUUC-Opr-070687	Ochotona princeps	56.73	6.00e-179	620.00
IUUC-Ont-072240	Oreochromis niloticus	58.55	0.00e+00	917.00
IUUC-Oan-073067	Ornithorhynchus anatinus	72.11	0.00e+00	1097.00
IUUC-Ocu-074852	Oryctolagus cuniculus	70.53	0.00e+00	1021.00
IUUC-Oga-089048	Otolemur garnettii	67.42	0.00e+00	907.00
IUUC-Oar-089339	Ovis aries	70.43	0.00e+00	1047.00
IUUC-Pan-092666	Papio anubis	69.99	0.00e+00	1006.00
IUUC-Psi-093116	Pelodiscus sinensis	73.47	0.00e+00	1114.00
IUUC-Ppa-095161	Physcomitrella patens	46.94	6.00e-09	55.10
IUUC-Pfo-097394	Poecilia formosa	61.66	0.00e+00	922.00
IUUC-Pab-098567	Pongo abelii	70.95	0.00e+00	1038.00
IUUC-Pca-100997	Procavia capensis	59.84	0.00e+00	814.00
IUUC-Pva-102500	Pteropus vampyrus	69.26	0.00e+00	991.00
IUUC-Rno-104974	Rattus norvegicus	68.57	0.00e+00	977.00
IUUC-Sja-107975	Schizosaccharomyces japonicus	46.43	2.00e-08	53.90
IUUC-Sly-111123	Solanum lycopersicum	39.13	3.00e-09	55.80
IUUC-Stu-112434	Solanum tuberosum	41.51	4.00e-09	55.50
IUUC-Sar-113420	Sorex araneus	67.88	0.00e+00	966.00
IUUC-Ssc-115679	Sus scrofa	71.03	0.00e+00	909.00
IUUC-Tgu-117069	Taeniopygia guttata	71.39	0.00e+00	1053.00
IUUC-Tru-118488	Takifugu rubripes	58.02	0.00e+00	833.00
IUUC-Tsy-119243	Tarsius syrichta	63.92	0.00e+00	705.00
IUUC-Tni-120584	Tetraodon nigroviridis	60.54	0.00e+00	908.00
IUUC-Tbe-127994	Tupaia belangeri	58.50	0.00e+00	829.00
IUUC-Ttr-128839	Tursiops truncatus	69.00	0.00e+00	993.00
IUUC-Vpa-130144	Vicugna pacos	63.90	0.00e+00	881.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence