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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105259
UUCD1 version UUC-RaN-00003
Ensembl Protein ID ENSRNOP00000072598.1
UniProt Accession P82458; TRI18_RAT
Genbank Protein ID AAD56247.1
Protein Name E3 ubiquitin-protein ligase Midline-1; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18
Genbank Nucleotide ID AF186461
Gene Name Mid1; Fxy; Trim18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000003613.7 ENSRNOT00000086414.1 ENSRNOP00000072598.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20352094
Classification
Family E-value Score Start End
E3 activity/RING/RING 7.00e-08 33.3 10 60
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw......pglknssskefrCPlCr 46
           C+iCle f+d pl+lpC H  +++C +++       + + +s ++f+CP+Cr
   Q: 10   CPICLELFED-PLLLPCAHSLCFNCAHRIlvshcaTNEPVESINAFQCPTCR 60
           **********.999************99999****999999**********8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
 Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.
Protein Sequence
(Fasta)
METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNEPVES INAFQCPTCR 60
HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MSSAEKVLCQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105259|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATAAGAGCCA GGCGGTCCTC GCTAGCCTGC GCCCGACTTT TCATAGGCTG GAAAAGGAAA 60
GGTTGAGAAA CTTGACATTG TCTTGGGTAG AGTGCGTATA GAAGCAGATC AAAGAATAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105259|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027727--MID1
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00041--fn3
PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005881--C:cytoplasmic microtubule
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0035372--P:protein localization to microtubule
KEGG rno:54252
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001734 Ailuropoda melanoleuca 95.80 0.00e+00 1308.00
IUUC-Apl-004060 Anas platyrhynchos 95.20 0.00e+00 1308.00
IUUC-Aca-005182 Anolis carolinensis 95.05 0.00e+00 1313.00
IUUC-Ame-010973 Astyanax mexicanus 81.21 0.00e+00 1130.00
IUUC-Bta-013266 Bos taurus 97.90 0.00e+00 1341.00
IUUC-Cja-019993 Callithrix jacchus 98.95 0.00e+00 1347.00
IUUC-Cfa-020747 Canis familiaris 97.90 0.00e+00 1342.00
IUUC-Cpo-021998 Cavia porcellus 99.25 0.00e+00 1357.00
IUUC-Csa-023229 Chlorocebus sabaeus 99.10 0.00e+00 1354.00
IUUC-Cin-025118 Ciona intestinalis 42.04 7.00e-158 550.00
IUUC-Csv-026320 Ciona savignyi 42.05 8.00e-158 550.00
IUUC-Dre-027831 Danio rerio 76.05 0.00e+00 1087.00
IUUC-Dno-028977 Dasypus novemcinctus 97.75 0.00e+00 1341.00
IUUC-Dor-030720 Dipodomys ordii 90.10 0.00e+00 1212.00
IUUC-Ete-032898 Echinops telfairi 90.10 0.00e+00 1208.00
IUUC-Eca-033732 Equus caballus 97.90 0.00e+00 1341.00
IUUC-Eeu-034564 Erinaceus europaeus 90.70 0.00e+00 1223.00
IUUC-Fca-036267 Felis catus 97.90 0.00e+00 1342.00
IUUC-Fal-037274 Ficedula albicollis 95.35 0.00e+00 1309.00
IUUC-Gga-040837 Gallus gallus 95.05 0.00e+00 1303.00
IUUC-Gac-041958 Gasterosteus aculeatus 81.17 0.00e+00 1165.00
IUUC-Ggo-044572 Gorilla gorilla 89.09 0.00e+00 1228.00
IUUC-Hsa-045947 Homo sapiens 99.10 0.00e+00 1354.00
IUUC-Lch-049502 Latimeria chalumnae 88.25 0.00e+00 1037.00
IUUC-Loc-052454 Lepisosteus oculatus 89.52 0.00e+00 1227.00
IUUC-Laf-053708 Loxodonta africana 95.89 0.00e+00 1333.00
IUUC-Mcc-055664 Macaca mulatta 98.95 0.00e+00 1352.00
IUUC-Meu-056180 Macropus eugenii 91.30 0.00e+00 1248.00
IUUC-Mga-059764 Meleagris gallopavo 94.46 0.00e+00 1287.00
IUUC-Mmr-060771 Microcebus murinus 98.50 0.00e+00 1350.00
IUUC-Mdo-062566 Monodelphis domestica 96.25 0.00e+00 1323.00
IUUC-Mmu-063950 Mus musculus 93.68 0.00e+00 1306.00
IUUC-Mpu-065690 Mustela putorius furo 97.60 0.00e+00 1338.00
IUUC-Mlu-067067 Myotis lucifugus 93.09 0.00e+00 1319.00
IUUC-Nle-069446 Nomascus leucogenys 98.95 0.00e+00 1354.00
IUUC-Ont-072567 Oreochromis niloticus 83.18 0.00e+00 1151.00
IUUC-Oan-073348 Ornithorhynchus anatinus 95.65 0.00e+00 1316.00
IUUC-Ola-087138 Oryzias latipes 79.44 0.00e+00 1121.00
IUUC-Oga-088162 Otolemur garnettii 98.35 0.00e+00 1349.00
IUUC-Oar-090200 Ovis aries 93.53 0.00e+00 1321.00
IUUC-Ptr-091126 Pan troglodytes 98.95 0.00e+00 1348.00
IUUC-Pan-091898 Papio anubis 99.10 0.00e+00 1354.00
IUUC-Psi-093184 Pelodiscus sinensis 94.45 0.00e+00 1308.00
IUUC-Pma-094517 Petromyzon marinus 26.14 2.00e-52 201.00
IUUC-Pfo-097477 Poecilia formosa 82.04 0.00e+00 1151.00
IUUC-Pab-098582 Pongo abelii 98.95 0.00e+00 1353.00
IUUC-Pca-100517 Procavia capensis 90.55 0.00e+00 1224.00
IUUC-Pva-103254 Pteropus vampyrus 98.73 0.00e+00 1104.00
IUUC-Sha-107060 Sarcophilus harrisii 96.37 0.00e+00 1313.00
IUUC-Sar-113538 Sorex araneus 95.95 0.00e+00 1320.00
IUUC-Ssc-115887 Sus scrofa 97.60 0.00e+00 1339.00
IUUC-Tgu-116818 Taeniopygia guttata 95.35 0.00e+00 1309.00
IUUC-Tru-117868 Takifugu rubripes 80.09 0.00e+00 1099.00
IUUC-Tsy-119648 Tarsius syrichta 99.10 0.00e+00 1354.00
IUUC-Tni-120841 Tetraodon nigroviridis 80.51 0.00e+00 1130.00
IUUC-Tbe-127963 Tupaia belangeri 93.70 0.00e+00 1294.00
IUUC-Ttr-129089 Tursiops truncatus 97.60 0.00e+00 1337.00
IUUC-Vpa-130092 Vicugna pacos 94.00 0.00e+00 1272.00
IUUC-Xtr-132778 Xenopus tropicalis 87.29 0.00e+00 1036.00
Created Date 25-Jun-2017

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