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Tag Content
UUCD2 ID IUUC-Bta-013230
UUCD1 version UUC-BoT-00052
Ensembl Protein ID ENSBTAP00000034530.4
UniProt Accession A5PK16; CCNF_BOVIN
Genbank Protein ID AAI42319.1
Protein Name Cyclin-F
Genbank Nucleotide ID BC142318
Gene Name CCNF
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000006591.5 ENSBTAT00000034643.4 ENSBTAP00000034530.4
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 86.57 0.00e+00 1247.00 IUUC-Hsa-046867
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Bos taurus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Protein Sequence
(Fasta)
MGSGGVIHCR CAKCFCYPSK RRIRRRPRNL TILNLPEDAL FHILKWLSVG DILAVRAVHS 60
HLKYLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD 120
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Protein Fasta Sequence


>IUUC-Bta-013230|E3,F-box|Bos taurus
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Nucleotide Sequence
(Fasta)
ATGGGGAGCG GAGGCGGTGA GCGCGGGGCG CGGGGCGCGG GGCGCGGTGG AGTGGCCTCC 60
AGACTGAGTG GGGCCAGCTT GAGCCTTTCG GCCCGGGGTT CGGATCGTCC CGACGGCGCC 120
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Nucleotide Fasta Sequence


>IUUC-Bta-013230|E3,F-box|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0195--Cyclin
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR028857--CCNF_metazoan
IPR013763--Cyclin-like
IPR004367--Cyclin_C-dom
IPR006671--Cyclin_N
IPR001810--F-box_dom
IPR013780--Glyco_hydro_b
PROSITE

PS00292--CYCLINS
PS50181--FBOX
Pfam

PF02984--Cyclin_C
PF00134--Cyclin_N
PF00646--F-box
SMART

SM00385--CYCLIN
SM01332--Cyclin_C
SM00256--FBOX
Gene Ontology

GO:0030054--C:cell junction
GO:0005814--C:centriole
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0010826--P:negative regulation of centrosome duplication
GO:0001890--P:placenta development
GO:0016567--P:protein ubiquitination
GO:0000320--P:re-entry into mitotic cell cycle
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG bta:505200
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001520 Ailuropoda melanoleuca 86.68 0.00e+00 1258.00
IUUC-Apl-003215 Anas platyrhynchos 68.46 0.00e+00 1068.00
IUUC-Ame-011700 Astyanax mexicanus 58.90 0.00e+00 695.00
IUUC-Cja-019256 Callithrix jacchus 85.64 0.00e+00 1284.00
IUUC-Cfa-020123 Canis familiaris 87.56 0.00e+00 1269.00
IUUC-Cpo-021599 Cavia porcellus 84.03 0.00e+00 1261.00
IUUC-Csa-023518 Chlorocebus sabaeus 78.89 0.00e+00 1123.00
IUUC-Cne-026925 Cryptococcus neoformans 35.29 3.80e+00 26.90
IUUC-Dre-028186 Danio rerio 51.76 0.00e+00 684.00
IUUC-Dno-029401 Dasypus novemcinctus 80.35 0.00e+00 1139.00
IUUC-Dor-031087 Dipodomys ordii 78.45 0.00e+00 1120.00
IUUC-Ete-032869 Echinops telfairi 82.28 9.00e-73 267.00
IUUC-Eca-033473 Equus caballus 91.07 0.00e+00 1316.00
IUUC-Eeu-034533 Erinaceus europaeus 68.71 4.00e-169 588.00
IUUC-Fca-035961 Felis catus 86.10 0.00e+00 1229.00
IUUC-Fal-036659 Ficedula albicollis 66.83 0.00e+00 1013.00
IUUC-Gmo-039557 Gadus morhua 58.27 2.00e-180 626.00
IUUC-Gga-040389 Gallus gallus 66.44 0.00e+00 877.00
IUUC-Gac-042059 Gasterosteus aculeatus 59.08 0.00e+00 657.00
IUUC-Ggo-044497 Gorilla gorilla 85.21 0.00e+00 1232.00
IUUC-Hsa-046867 Homo sapiens 85.21 0.00e+00 1221.00
IUUC-Itr-047922 Ictidomys tridecemlineatus 85.97 0.00e+00 1285.00
IUUC-Lch-050143 Latimeria chalumnae 66.31 0.00e+00 845.00
IUUC-Loc-052538 Lepisosteus oculatus 67.50 4.00e-45 173.00
IUUC-Laf-054481 Loxodonta africana 81.16 0.00e+00 1129.00
IUUC-Mcc-055426 Macaca mulatta 84.20 0.00e+00 1213.00
IUUC-Meu-056150 Macropus eugenii 70.45 0.00e+00 922.00
IUUC-Mga-059822 Meleagris gallopavo 63.97 0.00e+00 798.00
IUUC-Mmr-061785 Microcebus murinus 87.45 0.00e+00 1251.00
IUUC-Mdo-062763 Monodelphis domestica 72.73 0.00e+00 1067.00
IUUC-Mmu-064391 Mus musculus 81.83 0.00e+00 1184.00
IUUC-Mpu-065756 Mustela putorius furo 87.26 0.00e+00 1251.00
IUUC-Mlu-067607 Myotis lucifugus 87.18 0.00e+00 1281.00
IUUC-Nle-069147 Nomascus leucogenys 84.07 0.00e+00 1195.00
IUUC-Opr-071129 Ochotona princeps 83.31 0.00e+00 1252.00
IUUC-Ont-072031 Oreochromis niloticus 59.31 0.00e+00 688.00
IUUC-Oan-073514 Ornithorhynchus anatinus 64.55 3.00e-174 604.00
IUUC-Ocu-074914 Oryctolagus cuniculus 85.42 0.00e+00 1188.00
IUUC-Ola-086606 Oryzias latipes 56.40 0.00e+00 649.00
IUUC-Oga-088632 Otolemur garnettii 87.47 0.00e+00 1258.00
IUUC-Oar-090320 Ovis aries 92.52 0.00e+00 1382.00
IUUC-Ptr-091175 Pan troglodytes 85.34 0.00e+00 1222.00
IUUC-Pan-092003 Papio anubis 84.32 0.00e+00 1213.00
IUUC-Psi-093719 Pelodiscus sinensis 69.53 0.00e+00 1025.00
IUUC-Pma-094390 Petromyzon marinus 56.48 9.00e-125 439.00
IUUC-Pfo-096911 Poecilia formosa 58.81 0.00e+00 706.00
IUUC-Pab-097562 Pongo abelii 84.45 0.00e+00 1241.00
IUUC-Pca-100748 Procavia capensis 66.67 8.00e-109 388.00
IUUC-Pva-102168 Pteropus vampyrus 84.90 0.00e+00 1252.00
IUUC-Rno-105157 Rattus norvegicus 82.93 0.00e+00 1201.00
IUUC-Sha-107184 Sarcophilus harrisii 72.57 0.00e+00 1078.00
IUUC-Sar-113086 Sorex araneus 69.08 8.00e-86 311.00
IUUC-Ssc-116347 Sus scrofa 88.86 0.00e+00 1270.00
IUUC-Tgu-117463 Taeniopygia guttata 66.58 0.00e+00 999.00
IUUC-Tru-118348 Takifugu rubripes 59.64 0.00e+00 714.00
IUUC-Tsy-119459 Tarsius syrichta 84.12 6.00e-98 352.00
IUUC-Tni-120853 Tetraodon nigroviridis 61.23 0.00e+00 661.00
IUUC-Tbe-127361 Tupaia belangeri 74.70 0.00e+00 691.00
IUUC-Ttr-128214 Tursiops truncatus 80.63 0.00e+00 1109.00
IUUC-Xtr-132479 Xenopus tropicalis 66.67 0.00e+00 799.00
Created Date 25-Jun-2017

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