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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105157
UUCD1 version UUC-RaN-00942
Ensembl Protein ID ENSRNOP00000060445.1
UniProt Accession Q8K4F8; D3ZCW7; CCNF_RAT
Genbank Protein ID AAM46626.1
Protein Name Cyclin-F
Genbank Nucleotide ID AF410816
Gene Name Ccnf
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000007483.6 ENSRNOT00000064392.1 ENSRNOP00000060445.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 84.86 0.00e+00 1212.00 IUUC-Hsa-046867
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Protein Sequence
(Fasta)
MGSGGVIHCR CAKCFCYPTK RRIKRRPRNL TILSLPEDVL FHILKWLSVG DILAVRAVHS 60
HLKYLVDNHA SVWASASFQE LWPSPQNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD 120
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Protein Fasta Sequence


>IUUC-Rno-105157|E3,F-box|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTCTAAGGC GGCAGTGGTG GGAGCTCGGC GATGGGGAGC GGCGGTGGTG AGTGCTGGCG 60
GGAGCCGGGC AGGCGATGGG TCACACGGAA CAGAGACCGG AGGAGAACGG ACTCGGGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105157|E3,F-box|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0195--Cyclin
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR028857--CCNF_metazoan
IPR013763--Cyclin-like
IPR004367--Cyclin_C-dom
IPR006671--Cyclin_N
IPR001810--F-box_dom
IPR013780--Glyco_hydro_b
PROSITE

PS00292--CYCLINS
PS50181--FBOX
Pfam

PF02984--Cyclin_C
PF00134--Cyclin_N
PF00646--F-box
SMART

SM00385--CYCLIN
SM01332--Cyclin_C
SM00256--FBOX
Gene Ontology

GO:0030054--C:cell junction
GO:0005814--C:centriole
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0010826--P:negative regulation of centrosome duplication
GO:0001890--P:placenta development
GO:0016567--P:protein ubiquitination
GO:0000320--P:re-entry into mitotic cell cycle
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG rno:117524
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001520 Ailuropoda melanoleuca 81.56 0.00e+00 1162.00
IUUC-Apl-003215 Anas platyrhynchos 67.64 0.00e+00 1042.00
IUUC-Ame-011700 Astyanax mexicanus 58.90 0.00e+00 701.00
IUUC-Bta-013230 Bos taurus 82.93 0.00e+00 1186.00
IUUC-Cja-019256 Callithrix jacchus 83.04 0.00e+00 1202.00
IUUC-Cfa-020123 Canis familiaris 82.88 0.00e+00 1172.00
IUUC-Cpo-021599 Cavia porcellus 86.15 0.00e+00 1285.00
IUUC-Csa-023518 Chlorocebus sabaeus 78.88 0.00e+00 1103.00
IUUC-Dre-028186 Danio rerio 56.89 0.00e+00 691.00
IUUC-Dno-029401 Dasypus novemcinctus 78.46 0.00e+00 1122.00
IUUC-Dor-031087 Dipodomys ordii 79.49 0.00e+00 1142.00
IUUC-Ete-032869 Echinops telfairi 95.04 8.00e-78 284.00
IUUC-Eca-033473 Equus caballus 84.04 0.00e+00 1192.00
IUUC-Eeu-034533 Erinaceus europaeus 67.37 6.00e-162 564.00
IUUC-Fca-035961 Felis catus 82.70 0.00e+00 1144.00
IUUC-Fal-036659 Ficedula albicollis 65.43 0.00e+00 972.00
IUUC-Gmo-039557 Gadus morhua 58.27 0.00e+00 656.00
IUUC-Gga-040389 Gallus gallus 65.89 0.00e+00 833.00
IUUC-Gac-042059 Gasterosteus aculeatus 59.57 0.00e+00 668.00
IUUC-Ggo-044497 Gorilla gorilla 84.86 0.00e+00 1199.00
IUUC-Hsa-046867 Homo sapiens 84.86 0.00e+00 1195.00
IUUC-Itr-047922 Ictidomys tridecemlineatus 87.87 0.00e+00 1312.00
IUUC-Lch-050143 Latimeria chalumnae 64.86 0.00e+00 848.00
IUUC-Loc-052538 Lepisosteus oculatus 67.50 3.00e-45 174.00
IUUC-Laf-054481 Loxodonta africana 78.29 0.00e+00 1105.00
IUUC-Mcc-055426 Macaca mulatta 84.10 0.00e+00 1201.00
IUUC-Meu-056150 Macropus eugenii 69.86 0.00e+00 898.00
IUUC-Mga-059822 Meleagris gallopavo 64.53 0.00e+00 776.00
IUUC-Mmr-061785 Microcebus murinus 83.44 0.00e+00 1209.00
IUUC-Mdo-062763 Monodelphis domestica 72.45 0.00e+00 1060.00
IUUC-Mmu-064391 Mus musculus 95.62 0.00e+00 1388.00
IUUC-Mpu-065756 Mustela putorius furo 82.55 0.00e+00 1173.00
IUUC-Mlu-067607 Myotis lucifugus 82.34 0.00e+00 1171.00
IUUC-Nle-069147 Nomascus leucogenys 84.48 0.00e+00 1172.00
IUUC-Opr-071129 Ochotona princeps 82.17 0.00e+00 1212.00
IUUC-Ont-072031 Oreochromis niloticus 60.26 0.00e+00 709.00
IUUC-Oan-073514 Ornithorhynchus anatinus 64.76 1.00e-165 576.00
IUUC-Ocu-074914 Oryctolagus cuniculus 82.24 0.00e+00 1143.00
IUUC-Ola-086606 Oryzias latipes 57.59 0.00e+00 654.00
IUUC-Oga-088632 Otolemur garnettii 83.90 0.00e+00 1206.00
IUUC-Oar-090320 Ovis aries 78.91 0.00e+00 1136.00
IUUC-Ptr-091175 Pan troglodytes 84.99 0.00e+00 1196.00
IUUC-Pan-092003 Papio anubis 84.10 0.00e+00 1187.00
IUUC-Psi-093719 Pelodiscus sinensis 67.01 0.00e+00 994.00
IUUC-Pma-094390 Petromyzon marinus 55.13 2.00e-124 438.00
IUUC-Pfo-096911 Poecilia formosa 58.89 0.00e+00 717.00
IUUC-Pab-097562 Pongo abelii 84.73 0.00e+00 1226.00
IUUC-Pca-100748 Procavia capensis 67.33 3.00e-115 409.00
IUUC-Pva-102168 Pteropus vampyrus 78.91 0.00e+00 1132.00
IUUC-Sha-107184 Sarcophilus harrisii 71.94 0.00e+00 1075.00
IUUC-Stu-112748 Solanum tuberosum 35.00 2.00e-01 30.40
IUUC-Sar-113086 Sorex araneus 68.67 2.00e-85 310.00
IUUC-Ssc-116347 Sus scrofa 82.13 0.00e+00 1162.00
IUUC-Tgu-117463 Taeniopygia guttata 64.87 0.00e+00 964.00
IUUC-Tru-118348 Takifugu rubripes 59.04 0.00e+00 718.00
IUUC-Tsy-119459 Tarsius syrichta 81.97 1.00e-96 347.00
IUUC-Tni-120853 Tetraodon nigroviridis 60.42 0.00e+00 668.00
IUUC-Tbe-127361 Tupaia belangeri 73.48 0.00e+00 684.00
IUUC-Ttr-128214 Tursiops truncatus 73.13 0.00e+00 996.00
IUUC-Xtr-132479 Xenopus tropicalis 67.28 0.00e+00 796.00
IUUC-Xma-133153 Xiphophorus maculatus 58.22 0.00e+00 727.00
Created Date 25-Jun-2017

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