iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003715

Ensembl Protein ID

ENSAPLP00000010380.1

UniProt Accession

U3IT07; U3IT07_ANAPL

Genbank Protein ID

ENSAPLP00000010380

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01085579

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000010545.1	ENSAPLT00000011093.1	ENSAPLP00000010380.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-76	257.4	407	732

Active Site

Position(s)	Description	Evidence
702	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 9    levefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrlld 89
           +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ +++  ++d+++ np  + +  +e++G+++g al+ +++l 
   Q: 407  WECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTSNQGNSTGEARDMYVPNPscKDFAKYEWIGQIMGAALRGKEFLV 495
           45*****************************9999*99**********************999999999******************** PP
   S: 90   lplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeYv 174
           l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++ +     ++ +++++f    + +++l++++ +eL+p+G+++ V +e+++e++
   Q: 496  LALPGFVWKQLTGEEVSWsKDFPAVDSVLVKLLEVMEVM-----DKDTFEFKFGnelTYTTVLSDQRMVELIPNGSSTVVRYEDRKEFI 579
           *************************************77.....333455555533445567999************************ PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +lv ++rl+e  keq+ a+++G+ +v+p+ +l+l+t++ele  icG++e++v++lkk t++++ +++ +  +q+Fwe+l++f++e+r++
   Q: 580  RLVQKARLEE-SKEQIMAMQAGLLKVVPQAVLDLLTWQELEKKICGDPEVTVDALKKLTRFED-FEPLDTRVQYFWEALNNFTNEDRSR 666
           *********9.9*************************************************76.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y + ++++ekL+yA  ++ +++
   Q: 667  FLRFVTGRSRLPA--------RIYIYPDklgSETTDALPESSTCSSTLFLPNYATAKVCEEKLRYAAYNCVAID 732
           ************5........66777777989999*********************************998776 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MQEQLEEYKS GCELEEGWVL VCKHAEGGDR LVPVESTERI QRQQQLFGVD YKPVIRWEQV 60
VDLTYSLRLG AKPKPMEQDE AAVERLRFVP PTWTYECDED LVHFLYDHIG KEDENLGSVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGGAGC AGCTGGAAGA GTACAAGAGT GGCTGTGAGC TGGAGGAAGG CTGGGTGCTG 60
GTGTGCAAGC ACGCAGAAGG AGGGGACAGG CTGGTCCCGG TCGAGTCCAC GGAGAGGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	85.25	0.00e+00	1335.00
IUUC-Aca-004377	Anolis carolinensis	91.61	0.00e+00	1402.00
IUUC-Ame-011918	Astyanax mexicanus	71.52	0.00e+00	1097.00
IUUC-Bta-012736	Bos taurus	85.79	0.00e+00	1346.00
IUUC-Cja-019926	Callithrix jacchus	85.66	0.00e+00	1344.00
IUUC-Cfa-020753	Canis familiaris	88.21	0.00e+00	1077.00
IUUC-Cpo-021415	Cavia porcellus	85.39	0.00e+00	1343.00
IUUC-Csa-023096	Chlorocebus sabaeus	85.12	0.00e+00	1339.00
IUUC-Dre-028746	Danio rerio	78.68	0.00e+00	1177.00
IUUC-Dno-029293	Dasypus novemcinctus	87.95	0.00e+00	989.00
IUUC-Dor-031113	Dipodomys ordii	88.32	0.00e+00	1139.00
IUUC-Ete-032601	Echinops telfairi	78.78	0.00e+00	1195.00
IUUC-Eca-034198	Equus caballus	84.98	0.00e+00	1335.00
IUUC-Eeu-034708	Erinaceus europaeus	88.17	0.00e+00	839.00
IUUC-Fca-035478	Felis catus	85.39	0.00e+00	1340.00
IUUC-Fal-037366	Ficedula albicollis	96.89	0.00e+00	1473.00
IUUC-Gmo-039020	Gadus morhua	78.93	0.00e+00	1081.00
IUUC-Gga-040332	Gallus gallus	98.38	0.00e+00	1483.00
IUUC-Gac-042336	Gasterosteus aculeatus	78.06	0.00e+00	1219.00
IUUC-Ggo-045382	Gorilla gorilla	85.25	0.00e+00	1338.00
IUUC-Hsa-046562	Homo sapiens	85.25	0.00e+00	1338.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	85.39	0.00e+00	1340.00
IUUC-Lch-049606	Latimeria chalumnae	71.14	0.00e+00	898.00
IUUC-Loc-052448	Lepisosteus oculatus	70.11	0.00e+00	1055.00
IUUC-Laf-054507	Loxodonta africana	84.73	0.00e+00	1327.00
IUUC-Mcc-055690	Macaca mulatta	85.12	0.00e+00	1338.00
IUUC-Meu-055970	Macropus eugenii	87.57	0.00e+00	1319.00
IUUC-Mga-059654	Meleagris gallopavo	98.90	0.00e+00	1471.00
IUUC-Mmr-061069	Microcebus murinus	85.39	0.00e+00	1340.00
IUUC-Mdo-062547	Monodelphis domestica	90.07	0.00e+00	779.00
IUUC-Mmu-063096	Mus musculus	85.39	0.00e+00	1344.00
IUUC-Mpu-065846	Mustela putorius furo	85.52	0.00e+00	1341.00
IUUC-Mlu-067992	Myotis lucifugus	85.39	0.00e+00	1339.00
IUUC-Nle-069565	Nomascus leucogenys	84.59	0.00e+00	1238.00
IUUC-Opr-070853	Ochotona princeps	74.55	0.00e+00	922.00
IUUC-Ont-071628	Oreochromis niloticus	79.08	0.00e+00	1195.00
IUUC-Ocu-074094	Oryctolagus cuniculus	85.39	0.00e+00	1342.00
IUUC-Ola-087384	Oryzias latipes	78.44	0.00e+00	1229.00
IUUC-Oga-088224	Otolemur garnettii	85.25	0.00e+00	1342.00
IUUC-Oar-090043	Ovis aries	85.25	0.00e+00	1331.00
IUUC-Ptr-090852	Pan troglodytes	85.00	0.00e+00	1337.00
IUUC-Pan-092787	Papio anubis	85.12	0.00e+00	1340.00
IUUC-Psi-092986	Pelodiscus sinensis	78.52	0.00e+00	1056.00
IUUC-Pma-094416	Petromyzon marinus	42.11	6.00e-161	561.00
IUUC-Pfo-096720	Poecilia formosa	78.81	0.00e+00	1234.00
IUUC-Pab-098325	Pongo abelii	83.82	0.00e+00	989.00
IUUC-Pca-100885	Procavia capensis	73.34	0.00e+00	1080.00
IUUC-Pva-102829	Pteropus vampyrus	69.69	0.00e+00	1043.00
IUUC-Rno-104882	Rattus norvegicus	85.93	0.00e+00	1345.00
IUUC-Sha-106811	Sarcophilus harrisii	84.91	2.00e-110	392.00
IUUC-Sar-113020	Sorex araneus	76.01	0.00e+00	660.00
IUUC-Ssc-115436	Sus scrofa	84.44	3.00e-139	487.00
IUUC-Tgu-117042	Taeniopygia guttata	97.29	0.00e+00	1473.00
IUUC-Tru-118419	Takifugu rubripes	76.79	0.00e+00	1149.00
IUUC-Tsy-118829	Tarsius syrichta	82.34	0.00e+00	808.00
IUUC-Tni-120410	Tetraodon nigroviridis	63.97	0.00e+00	915.00
IUUC-Tbe-128113	Tupaia belangeri	88.25	0.00e+00	717.00
IUUC-Ttr-128167	Tursiops truncatus	80.78	0.00e+00	1243.00
IUUC-Xtr-132910	Xenopus tropicalis	72.06	0.00e+00	1045.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence