iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054930

UUCD1 version

UUC-MaM-00062

Ensembl Protein ID

ENSMMUP00000013259.2

UniProt Accession

F6QY96; F6QY96_MACMU

Genbank Protein ID

AFE80708.1; AFH27359.1; EHH26034.1

Protein Name

Putative E3 ubiquitin-protein ligase HERC3

Genbank Nucleotide ID

JSUE03033964; JU470555; CM001257

Gene Name

HERC3; EGK_15915

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000010138.3	ENSMMUT00000014157.3	ENSMMUP00000013259.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-94	318.2	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+ +g+a++++ ++dl
   Q: 726  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGITCGLAIYNSTVVDL 807
           899******************************************9999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k  ledl+e+ p+  +sl+e++++  +d+ee+ ++l+f++  e++g +++++L+pgG+n+ V ++N++e+v+++
   Q: 808  HFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEET-FCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAY 893
           *************************************99999997.******99********************************* PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++ +++e ++af++Gf +v+  ++l+lF+++el+ ++ G++++++e+l++++ ykg+y++++p+++ Fwe+++ef  e++k+f
   Q: 894  VNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+a+l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ysskeil  +L+ A ++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMASLQ---IVIQStASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
           *******************...8888867788**************************************97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGAATTTG GGGGGTATCT GCCAAGCACT GAAGATTTTG GACATTGTCT TTTCCTGCTG 60
TTGAAAGAGA CCCTCTACAT ATATACAACA TTCAGGTAAT TGCTTCTAAG CTTACTTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mcc:703108

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	99.05	0.00e+00	2099.00
IUUC-Apl-003535	Anas platyrhynchos	88.38	0.00e+00	1887.00
IUUC-Aca-005223	Anolis carolinensis	85.62	0.00e+00	1836.00
IUUC-Ame-010816	Astyanax mexicanus	65.92	0.00e+00	1164.00
IUUC-Bta-013373	Bos taurus	98.00	0.00e+00	2088.00
IUUC-Cel-018150	Caenorhabditis elegans	33.12	3.00e-154	539.00
IUUC-Cja-019609	Callithrix jacchus	99.24	0.00e+00	2102.00
IUUC-Cfa-021071	Canis familiaris	98.67	0.00e+00	2094.00
IUUC-Cpo-021548	Cavia porcellus	97.71	0.00e+00	2077.00
IUUC-Csa-023987	Chlorocebus sabaeus	99.90	0.00e+00	2114.00
IUUC-Cho-024325	Choloepus hoffmanni	98.41	0.00e+00	1209.00
IUUC-Dre-027472	Danio rerio	66.44	0.00e+00	1399.00
IUUC-Dno-029241	Dasypus novemcinctus	97.24	0.00e+00	2065.00
IUUC-Dor-030672	Dipodomys ordii	92.54	0.00e+00	1138.00
IUUC-Ete-032642	Echinops telfairi	92.29	0.00e+00	1901.00
IUUC-Eca-033646	Equus caballus	98.67	0.00e+00	2095.00
IUUC-Eeu-035098	Erinaceus europaeus	85.14	0.00e+00	1385.00
IUUC-Fal-036952	Ficedula albicollis	88.10	0.00e+00	1881.00
IUUC-Gmo-039297	Gadus morhua	64.00	0.00e+00	1317.00
IUUC-Gga-040591	Gallus gallus	87.35	0.00e+00	1863.00
IUUC-Gac-041741	Gasterosteus aculeatus	65.37	0.00e+00	1383.00
IUUC-Gma-043616	Glycine max	37.79	1.00e-51	197.00
IUUC-Ggo-044769	Gorilla gorilla	99.62	0.00e+00	2105.00
IUUC-Hsa-046066	Homo sapiens	99.71	0.00e+00	2110.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	98.86	0.00e+00	2092.00
IUUC-Lch-050301	Latimeria chalumnae	73.33	0.00e+00	1618.00
IUUC-Loc-052803	Lepisosteus oculatus	67.44	0.00e+00	1460.00
IUUC-Laf-053364	Loxodonta africana	98.48	0.00e+00	2088.00
IUUC-Meu-056274	Macropus eugenii	79.27	0.00e+00	871.00
IUUC-Mga-059563	Meleagris gallopavo	87.81	0.00e+00	1877.00
IUUC-Mmr-060792	Microcebus murinus	96.67	0.00e+00	2040.00
IUUC-Mdo-062195	Monodelphis domestica	91.72	0.00e+00	1959.00
IUUC-Mmu-063855	Mus musculus	95.52	0.00e+00	2047.00
IUUC-Mpu-066308	Mustela putorius furo	99.14	0.00e+00	2105.00
IUUC-Mlu-066927	Myotis lucifugus	98.00	0.00e+00	2079.00
IUUC-Nle-070090	Nomascus leucogenys	99.71	0.00e+00	2110.00
IUUC-Opr-070891	Ochotona princeps	86.29	0.00e+00	1776.00
IUUC-Ont-072201	Oreochromis niloticus	64.18	0.00e+00	1342.00
IUUC-Ocu-074770	Oryctolagus cuniculus	98.19	0.00e+00	2089.00
IUUC-Ola-086550	Oryzias latipes	65.25	0.00e+00	1390.00
IUUC-Olu-087836	Ostreococcus lucimarinus	34.44	9.00e-42	164.00
IUUC-Oga-088831	Otolemur garnettii	98.67	0.00e+00	2089.00
IUUC-Oar-090449	Ovis aries	97.90	0.00e+00	2082.00
IUUC-Pan-092135	Papio anubis	99.81	0.00e+00	2110.00
IUUC-Psi-093832	Pelodiscus sinensis	85.54	0.00e+00	1877.00
IUUC-Pfo-097268	Poecilia formosa	65.72	0.00e+00	1386.00
IUUC-Pab-098249	Pongo abelii	99.43	0.00e+00	2105.00
IUUC-Pca-100855	Procavia capensis	93.72	0.00e+00	1427.00
IUUC-Pva-102506	Pteropus vampyrus	89.91	0.00e+00	1845.00
IUUC-Rno-105242	Rattus norvegicus	95.81	0.00e+00	2090.00
IUUC-Sha-107186	Sarcophilus harrisii	89.39	0.00e+00	1199.00
IUUC-Sar-113612	Sorex araneus	95.40	0.00e+00	748.00
IUUC-Ssc-115473	Sus scrofa	97.81	0.00e+00	2081.00
IUUC-Tgu-116974	Taeniopygia guttata	88.30	0.00e+00	1860.00
IUUC-Tru-118077	Takifugu rubripes	63.74	0.00e+00	1320.00
IUUC-Tsy-119619	Tarsius syrichta	87.33	0.00e+00	1861.00
IUUC-Tni-120807	Tetraodon nigroviridis	63.83	0.00e+00	1341.00
IUUC-Tbe-127640	Tupaia belangeri	94.67	0.00e+00	1956.00
IUUC-Ttr-129172	Tursiops truncatus	97.52	0.00e+00	2070.00
IUUC-Vpa-130442	Vicugna pacos	83.05	0.00e+00	1702.00
IUUC-Xtr-132194	Xenopus tropicalis	71.70	0.00e+00	1442.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence