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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046411
Ensembl Protein ID ENSP00000263246.3
UniProt Accession Q9UNF0; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9Y4V2; PACN2_HUMAN
Genbank Protein ID AAD41781.1; CAB66779.1; CAG30422.1; CAI20163.1; CAI20163.1; CAI20948.1; CAI20948.1; AAH08037.1; CAB97538.1
Protein Name Protein kinase C and casein kinase substrate in neurons protein 2; Syndapin-2; Syndapin-II
Genbank Nucleotide ID AF128536; AL136845; CR456536; AL022476; AL049758; AL049758; AL022476; BC008037; AL389984
Gene Name PACSIN2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100266.18 ENST00000507586.1 ENSP00000422788.1
ENSG00000100266.18 ENST00000263246.7 ENSP00000263246.3
ENSG00000100266.18 ENST00000407585.5 ENSP00000385952.1
ENSG00000100266.18 ENST00000634914.1 ENSP00000489297.1
ENSG00000100266.18 ENST00000453643.5 ENSP00000398573.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.90e-16 59.4 430 486
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++lydye+q+ deL++k+Gd ++ + ++e ++gW+kg + ++g+ Gl P+n+ve ++
   Q: 430  RVRALYDYEGQEHDELSFKAGDELTKM-EDEDEQGWCKG-RLDNGQVGLYPANYVEAIQ 486
           799***********************9.9**********.59*************9885 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
 Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.
Protein Sequence
(Fasta)
MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCSD LMNCLHERAR IEKAYAQQLT 60
EWARRWRQLV EKGPQYGTVE KAWMAFMSEA ERVSELHLEV KASLMNDDFE KIKNWQKEAF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046411|UBD,SH3|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCGGCCGCAG GGGTCTGGGC AGGGCTGGGC AGTGCTGCCG GAGCAAAAGC GGTAGCGGGA 60
GCCCGGCCGG AGCTGGGTCT GGAGACGCCG TGGCAGCCTG AACGGAGTGT GCGACGGATT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046411|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR028521--PACSIN2
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0005901--C:caveola
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0019898--C:extrinsic component of membrane
GO:0005925--C:focal adhesion
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016607--C:nuclear speck
GO:0005886--C:plasma membrane
GO:0055038--C:recycling endosome membrane
GO:0032587--C:ruffle membrane
GO:0045296--F:cadherin binding
GO:0042802--F:identical protein binding
GO:0070300--F:phosphatidic acid binding
GO:0005215--F:transporter activity
GO:0030036--P:actin cytoskeleton organization
GO:0070836--P:caveola assembly
GO:0072584--P:caveolin-mediated endocytosis
GO:0048858--P:cell projection morphogenesis
GO:0061024--P:membrane organization
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0036010--P:protein localization to endosome
GO:0030100--P:regulation of endocytosis
KEGG hsa:11252
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001887 Ailuropoda melanoleuca 93.83 0.00e+00 861.00
IUUC-Apl-003574 Anas platyrhynchos 87.47 0.00e+00 775.00
IUUC-Aca-004251 Anolis carolinensis 80.62 0.00e+00 743.00
IUUC-Ame-011756 Astyanax mexicanus 66.21 0.00e+00 665.00
IUUC-Bta-013193 Bos taurus 90.12 0.00e+00 802.00
IUUC-Cel-018168 Caenorhabditis elegans 31.92 8.00e-61 228.00
IUUC-Cja-018756 Callithrix jacchus 97.12 0.00e+00 865.00
IUUC-Cfa-020545 Canis familiaris 94.03 0.00e+00 892.00
IUUC-Cpo-022000 Cavia porcellus 89.30 0.00e+00 893.00
IUUC-Csa-024030 Chlorocebus sabaeus 98.43 0.00e+00 794.00
IUUC-Cin-025707 Ciona intestinalis 42.54 5.00e-106 378.00
IUUC-Csv-026244 Ciona savignyi 42.11 3.00e-54 204.00
IUUC-Dre-028104 Danio rerio 63.20 1.00e-161 562.00
IUUC-Dno-029429 Dasypus novemcinctus 92.73 0.00e+00 786.00
IUUC-Dor-030122 Dipodomys ordii 87.45 0.00e+00 786.00
IUUC-Dme-032120 Drosophila melanogaster 42.69 1.00e-104 373.00
IUUC-Eca-033367 Equus caballus 91.77 0.00e+00 838.00
IUUC-Eeu-034821 Erinaceus europaeus 76.75 0.00e+00 670.00
IUUC-Fca-036079 Felis catus 94.44 0.00e+00 861.00
IUUC-Fal-036682 Ficedula albicollis 87.23 0.00e+00 772.00
IUUC-Gmo-039681 Gadus morhua 64.49 2.00e-155 542.00
IUUC-Gga-040717 Gallus gallus 87.45 0.00e+00 774.00
IUUC-Gac-042262 Gasterosteus aculeatus 63.93 2.00e-169 588.00
IUUC-Ggo-044841 Gorilla gorilla 99.38 0.00e+00 857.00
IUUC-Itr-049063 Ictidomys tridecemlineatus 94.86 0.00e+00 838.00
IUUC-Loc-051975 Lepisosteus oculatus 70.23 0.00e+00 683.00
IUUC-Laf-053839 Loxodonta africana 89.77 0.00e+00 815.00
IUUC-Mcc-055783 Macaca mulatta 98.97 0.00e+00 854.00
IUUC-Mga-060087 Meleagris gallopavo 81.91 0.00e+00 709.00
IUUC-Mmr-060827 Microcebus murinus 95.06 0.00e+00 873.00
IUUC-Mmu-064109 Mus musculus 93.83 0.00e+00 862.00
IUUC-Mpu-066591 Mustela putorius furo 94.24 0.00e+00 868.00
IUUC-Mlu-067826 Myotis lucifugus 93.42 0.00e+00 860.00
IUUC-Nle-069797 Nomascus leucogenys 99.38 0.00e+00 857.00
IUUC-Oan-073076 Ornithorhynchus anatinus 84.06 4.00e-153 533.00
IUUC-Ocu-074425 Oryctolagus cuniculus 93.83 0.00e+00 839.00
IUUC-Ola-087556 Oryzias latipes 64.84 2.00e-161 562.00
IUUC-Oga-089009 Otolemur garnettii 85.66 0.00e+00 786.00
IUUC-Oar-089806 Ovis aries 90.53 0.00e+00 806.00
IUUC-Ptr-091111 Pan troglodytes 99.18 0.00e+00 854.00
IUUC-Pan-091749 Papio anubis 96.27 0.00e+00 840.00
IUUC-Psi-093704 Pelodiscus sinensis 87.02 0.00e+00 788.00
IUUC-Pfo-096680 Poecilia formosa 62.96 4.00e-166 578.00
IUUC-Pab-098584 Pongo abelii 99.68 3.00e-169 587.00
IUUC-Pva-102649 Pteropus vampyrus 93.00 0.00e+00 836.00
IUUC-Rno-105431 Rattus norvegicus 93.24 0.00e+00 874.00
IUUC-Sha-106641 Sarcophilus harrisii 89.48 0.00e+00 808.00
IUUC-Sar-113461 Sorex araneus 81.69 0.00e+00 724.00
IUUC-Ssc-115349 Sus scrofa 93.61 0.00e+00 829.00
IUUC-Tgu-116876 Taeniopygia guttata 87.45 0.00e+00 772.00
IUUC-Tru-118306 Takifugu rubripes 67.20 2.00e-174 605.00
IUUC-Tsy-118901 Tarsius syrichta 84.18 4.00e-151 528.00
IUUC-Tni-120120 Tetraodon nigroviridis 67.62 8.00e-178 616.00
IUUC-Xtr-132925 Xenopus tropicalis 80.29 0.00e+00 740.00
Created Date 25-Jun-2017

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