iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000005637.1	ENSONIT00000007100.1	ENSONIP00000007095.1
ENSONIG00000005637.1	ENSONIT00000007101.1	ENSONIP00000007096.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-97	326.5	1678	2057

Active Site

Position(s)	Description	Evidence
2024	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.......................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ + n++     +                       +   
   Q: 1678 RAMLEIQYENEVGTGL-GPTQEFYALVSQELQRADLGLWRGEEVTLANPKGNQEGT---KymfssrglfavpfgrttkpahiaKIKM 1760
           56899***********.**********************65555444443333322...12345567777789*********99999 PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikenaes........................ 130
            F+flG+l++ka++d rlldlpl  +fyk +l++++s+  +dl ++dp ++ks++ +++   +                        
   Q: 1761 KFRFLGKLMAKAIMDFRLLDLPLGLPFYKWMLRHEMSIssHDLVNIDPGVAKSIQHLEDIIRQkkrleqdrsqtretlqqaleslnm 1847
           9*********************************866666******************99833445555666667777544444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG+++pVt+ N+eeY +lvv ++l+eg+ +q+e+freGf++v+pl++l++F
   Q: 1848 ngcSVED------------LgldftLPGFPNIELKKGGKDVPVTIYNLEEYLRLVVYWTLNEGVSRQFESFREGFESVFPLHHLQYF 1922
           4444444............34455578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  e++dv++l + ++ ++gyt+ds+a+++++evl++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1923 YPEELDQLLCGSksETWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 2009
           ***********98889*********************************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 2010 stENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGqQSFHLS 2057
           988888***************************************985 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MSNRPNSNPG GSLRRSQRNT AAAQPQDHTV AGRLQSEQVK HKANSPPESR RPNSKAPKAT 60
ASSATGQSRG HSSRRSGLTL SVASFVLQDD PEAAGTSEQE RPGHQSKSEG NRGLKRSEAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATGGTAG TGTCTAGAAA GGGTATGTCC CTTCAGGAGA GAGGTGCCAA TGTCCAACCG 60
GCCTAATTCC AATCCAGGGG GGTCACTGCG CCGTTCACAG AGGAACACTG CTGCGGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT
PF02825--WWE

SMART

SM00119--HECTc
SM00678--WWE

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.37	5.00e-128	453.00
IUUC-Aml-001502	Ailuropoda melanoleuca	82.23	0.00e+00	3090.00
IUUC-Atr-002821	Amborella trichopoda	37.87	4.00e-120	427.00
IUUC-Apl-003531	Anas platyrhynchos	81.27	0.00e+00	3014.00
IUUC-Aly-005962	Arabidopsis lyrata	39.02	3.00e-117	417.00
IUUC-Ath-006636	Arabidopsis thaliana	38.45	1.00e-117	419.00
IUUC-Ago-007875	Ashbya gossypii	36.26	1.00e-82	301.00
IUUC-Acl-008242	Aspergillus clavatus	36.87	4.00e-118	420.00
IUUC-Afl-008736	Aspergillus flavus	40.33	1.00e-116	415.00
IUUC-Afu-008812	Aspergillus fumigatus	37.33	2.00e-120	428.00
IUUC-Ani-009407	Aspergillus nidulans	37.74	9.00e-115	409.00
IUUC-Ang-009763	Aspergillus niger	40.18	5.00e-110	393.00
IUUC-Aor-009941	Aspergillus oryzae	31.50	2.00e-119	424.00
IUUC-Ate-010459	Aspergillus terreus	38.52	7.00e-92	333.00
IUUC-Ame-011761	Astyanax mexicanus	93.91	0.00e+00	3150.00
IUUC-Bgr-012265	Blumeria graminis	35.87	2.00e-105	378.00
IUUC-Bta-013070	Bos taurus	80.25	0.00e+00	3035.00
IUUC-Bci-013890	Botrytis cinerea	39.88	2.00e-103	371.00
IUUC-Bdi-014046	Brachypodium distachyon	37.75	3.00e-124	440.00
IUUC-Bol-015942	Brassica oleracea	43.51	1.00e-116	415.00
IUUC-Bra-016849	Brassica rapa	43.51	5.00e-116	413.00
IUUC-Cja-019046	Callithrix jacchus	86.80	0.00e+00	2967.00
IUUC-Cfa-020521	Canis familiaris	80.78	0.00e+00	2987.00
IUUC-Cpo-021639	Cavia porcellus	79.03	0.00e+00	2999.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.62	1.00e-90	327.00
IUUC-Csa-023231	Chlorocebus sabaeus	88.39	0.00e+00	3037.00
IUUC-Cho-024380	Choloepus hoffmanni	80.48	0.00e+00	1896.00
IUUC-Cin-025482	Ciona intestinalis	50.09	4.00e-157	548.00
IUUC-Csv-026121	Ciona savignyi	48.12	0.00e+00	1539.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	34.59	1.00e-109	392.00
IUUC-Cne-026857	Cryptococcus neoformans	40.49	1.00e-96	348.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.52	2.00e-75	278.00
IUUC-Dre-028174	Danio rerio	94.07	0.00e+00	3207.00
IUUC-Dor-030939	Dipodomys ordii	76.48	0.00e+00	1266.00
IUUC-Dse-031444	Dothistroma septosporum	39.68	5.00e-108	387.00
IUUC-Dme-032162	Drosophila melanogaster	58.97	0.00e+00	723.00
IUUC-Ete-032345	Echinops telfairi	79.50	0.00e+00	2037.00
IUUC-Eca-033229	Equus caballus	81.89	0.00e+00	3037.00
IUUC-Eeu-035205	Erinaceus europaeus	71.41	0.00e+00	2582.00
IUUC-Fca-036444	Felis catus	80.36	0.00e+00	3053.00
IUUC-Fal-037131	Ficedula albicollis	83.73	0.00e+00	3184.00
IUUC-Fox-038035	Fusarium oxysporum	35.51	1.00e-107	384.00
IUUC-Fso-038320	Fusarium solani	35.95	6.00e-108	386.00
IUUC-Gmo-039497	Gadus morhua	89.36	0.00e+00	3360.00
IUUC-Ggr-040057	Gaeumannomyces graminis	34.58	9.00e-105	376.00
IUUC-Gga-041021	Gallus gallus	83.83	0.00e+00	3187.00
IUUC-Gac-042474	Gasterosteus aculeatus	92.05	0.00e+00	3460.00
IUUC-Gma-043060	Glycine max	38.68	2.00e-121	431.00
IUUC-Ggo-044855	Gorilla gorilla	86.75	0.00e+00	2966.00
IUUC-Hsa-046147	Homo sapiens	86.35	0.00e+00	2962.00
IUUC-Hvu-047775	Hordeum vulgare	38.37	2.00e-126	447.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	88.13	0.00e+00	3023.00
IUUC-Kpa-049098	Komagataella pastoris	37.06	2.00e-84	308.00
IUUC-Lch-049818	Latimeria chalumnae	87.46	0.00e+00	2947.00
IUUC-Lpe-051017	Leersia perrieri	37.45	6.00e-119	423.00
IUUC-Loc-051777	Lepisosteus oculatus	88.76	0.00e+00	3396.00
IUUC-Lma-052990	Leptosphaeria maculans	36.02	2.00e-113	404.00
IUUC-Laf-053727	Loxodonta africana	81.76	0.00e+00	3066.00
IUUC-Mcc-055799	Macaca mulatta	88.63	0.00e+00	2962.00
IUUC-Meu-056065	Macropus eugenii	82.69	0.00e+00	1892.00
IUUC-Mor-057054	Magnaporthe oryzae	37.68	2.00e-103	371.00
IUUC-Mpo-057417	Magnaporthe poae	38.29	2.00e-105	378.00
IUUC-Mtr-057849	Medicago truncatula	36.93	2.00e-114	408.00
IUUC-Mla-058870	Melampsora laricipopulina	41.89	3.00e-109	390.00
IUUC-Mga-059580	Meleagris gallopavo	81.72	0.00e+00	2670.00
IUUC-Mvi-060507	Microbotryum violaceum	40.00	8.00e-116	413.00
IUUC-Mmr-060816	Microcebus murinus	83.01	0.00e+00	3148.00
IUUC-Mdo-062866	Monodelphis domestica	81.27	0.00e+00	2943.00
IUUC-Mmu-063906	Mus musculus	81.90	0.00e+00	3107.00
IUUC-Mac-064675	Musa acuminata	37.72	5.00e-111	395.00
IUUC-Mpu-066199	Mustela putorius furo	81.84	0.00e+00	3048.00
IUUC-Mlu-067110	Myotis lucifugus	82.05	0.00e+00	3077.00
IUUC-Nfi-068482	Neosartorya fischeri	37.18	3.00e-119	424.00
IUUC-Ncr-068906	Neurospora crassa	37.92	9.00e-106	379.00
IUUC-Nle-069410	Nomascus leucogenys	86.62	0.00e+00	2955.00
IUUC-Opr-070401	Ochotona princeps	75.08	0.00e+00	1715.00
IUUC-Oan-073121	Ornithorhynchus anatinus	83.60	0.00e+00	3228.00
IUUC-Ocu-074623	Oryctolagus cuniculus	88.35	0.00e+00	2959.00
IUUC-Oba-075380	Oryza barthii	31.63	2.00e-115	411.00
IUUC-Obr-076915	Oryza brachyantha	36.80	3.00e-119	424.00
IUUC-Ogl-077055	Oryza glaberrima	37.61	2.00e-119	424.00
IUUC-Ogu-078892	Oryza glumaepatula	31.31	7.00e-115	409.00
IUUC-Oin-079256	Oryza indica	37.29	3.00e-118	421.00
IUUC-Olo-080343	Oryza longistaminata	37.57	4.00e-118	420.00
IUUC-Ome-081422	Oryza meridionalis	37.43	5.00e-118	420.00
IUUC-Oni-083047	Oryza nivara	31.63	3.00e-116	413.00
IUUC-Opu-083641	Oryza punctata	35.47	1.00e-109	392.00
IUUC-Oru-084439	Oryza rufipogon	31.32	4.00e-115	409.00
IUUC-Osa-085972	Oryza sativa	37.46	2.00e-117	416.00
IUUC-Ola-087173	Oryzias latipes	92.58	0.00e+00	3489.00
IUUC-Olu-087871	Ostreococcus lucimarinus	37.43	1.00e-88	320.00
IUUC-Oga-087908	Otolemur garnettii	81.43	0.00e+00	3093.00
IUUC-Oar-090277	Ovis aries	81.32	0.00e+00	3104.00
IUUC-Ptr-091543	Pan troglodytes	86.40	0.00e+00	2962.00
IUUC-Pan-092243	Papio anubis	88.58	0.00e+00	2960.00
IUUC-Psi-093150	Pelodiscus sinensis	82.84	0.00e+00	3169.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.00	1.00e-114	408.00
IUUC-Ppa-095181	Physcomitrella patens	41.94	4.00e-106	379.00
IUUC-Pfo-096267	Poecilia formosa	94.90	0.00e+00	3507.00
IUUC-Pab-098072	Pongo abelii	86.90	0.00e+00	2965.00
IUUC-Pop-099190	Populus trichocarpa	37.29	3.00e-117	417.00
IUUC-Pca-100311	Procavia capensis	76.55	0.00e+00	2764.00
IUUC-Ppe-101284	Prunus persica	37.75	2.00e-118	421.00
IUUC-Pva-102215	Pteropus vampyrus	76.01	0.00e+00	1035.00
IUUC-Pgr-103694	Puccinia graminis	36.01	2.00e-107	384.00
IUUC-Ptt-103916	Puccinia triticina	39.33	3.00e-103	370.00
IUUC-Pte-104346	Pyrenophora teres	40.60	9.00e-114	405.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	40.60	3.00e-113	404.00
IUUC-Rno-105315	Rattus norvegicus	88.35	0.00e+00	2940.00
IUUC-Sce-106273	Saccharomyces cerevisiae	34.07	6.00e-70	259.00
IUUC-Sha-106835	Sarcophilus harrisii	82.58	0.00e+00	3211.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	38.87	1.00e-98	355.00
IUUC-Spo-108081	Schizosaccharomyces pombe	40.04	3.00e-98	353.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.04	4.00e-107	383.00
IUUC-Smo-109590	Selaginella moellendorffii	43.28	3.00e-113	404.00
IUUC-Sit-109757	Setaria italica	37.77	7.00e-124	439.00
IUUC-Sly-111469	Solanum lycopersicum	39.28	2.00e-121	431.00
IUUC-Stu-112896	Solanum tuberosum	37.64	3.00e-106	379.00
IUUC-Sar-113224	Sorex araneus	68.28	0.00e+00	1506.00
IUUC-Sbi-114313	Sorghum bicolor	37.86	4.00e-125	443.00
IUUC-Sre-114993	Sporisorium reilianum	33.29	6.00e-102	367.00
IUUC-Ssc-115535	Sus scrofa	78.29	0.00e+00	2969.00
IUUC-Tgu-117493	Taeniopygia guttata	81.46	0.00e+00	2424.00
IUUC-Tru-118669	Takifugu rubripes	91.90	0.00e+00	3422.00
IUUC-Tsy-119373	Tarsius syrichta	81.32	0.00e+00	1632.00
IUUC-Tni-120049	Tetraodon nigroviridis	84.77	0.00e+00	929.00
IUUC-Tca-121779	Theobroma cacao	38.40	1.00e-115	412.00
IUUC-Tre-122195	Trichoderma reesei	35.37	2.00e-104	375.00
IUUC-Tvi-122650	Trichoderma virens	34.91	3.00e-105	377.00
IUUC-Tae-123580	Triticum aestivum	38.29	5.00e-126	445.00
IUUC-Tur-126295	Triticum urartu	38.37	1.00e-127	451.00
IUUC-Tme-126964	Tuber melanosporum	40.84	3.00e-107	384.00
IUUC-Tbe-128149	Tupaia belangeri	74.53	0.00e+00	1122.00
IUUC-Ttr-128165	Tursiops truncatus	84.36	0.00e+00	2747.00
IUUC-Uma-129365	Ustilago maydis	35.16	6.00e-88	320.00
IUUC-Vda-129725	Verticillium dahliae	41.08	2.00e-107	385.00
IUUC-Vpa-130678	Vicugna pacos	84.92	0.00e+00	2393.00
IUUC-Vvi-131147	Vitis vinifera	38.98	8.00e-122	432.00
IUUC-Xtr-132636	Xenopus tropicalis	79.79	0.00e+00	2978.00
IUUC-Xma-133458	Xiphophorus maculatus	94.90	0.00e+00	3556.00
IUUC-Yli-134481	Yarrowia lipolytica	37.91	9.00e-99	355.00
IUUC-Zma-135782	Zea mays	37.55	7.00e-119	422.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence